Studies of the Behavioral Sequences: The Neuroethological Morphology Concept Crossing Ethology and Functional Morphology

Bels, Vincent; Pallandre, Jean-Pierre; Pellé, Éric; Kirchhoff, Florence

doi:10.3390/ani12111336

Cited by 6 publications

(6 citation statements)

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“…To further investigate the organisation of these social contacts, we examined the temporal succession of simple behavioural events. This approach should contribute to a better understanding of the functions of the different behaviours ( Wiltschko et al, 2015 ; Bels et al, 2022 ). For this analysis, we defined exclusive behavioural events (i.e., events that could not occur at the same time; see methods for definitions).…”

Section: Resultsmentioning

confidence: 99%

Day-to-day spontaneous social behaviours is quantitatively and qualitatively affected in a 16p11.2 deletion mouse model

Rusu,

Chevalier,

de Chaumont

et al. 2023

Front. Behav. Neurosci.

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BackgroundAutism spectrum disorders affect more than 1% of the population, impairing social communication and increasing stereotyped behaviours. A micro-deletion of the 16p11.2 BP4-BP5 chromosomic region has been identified in 1% of patients also displaying intellectual disabilities. In mouse models generated to understand the mechanisms of this deletion, learning and memory deficits were pervasive in most genetic backgrounds, while social communication deficits were only detected in some models.MethodsTo complement previous studies, we itemized the social deficits in the mouse model of 16p11.2 deletion on a hybrid C57BL/6N × C3H.Pde6b+ genetic background. We examined whether behavioural deficits were visible over long-term observation periods lasting several days and nights, to parallel everyday-life assessment of patients. We recorded the individual and social behaviours of mice carrying a heterozygous deletion of the homologous 16p11.2 chromosomic region (hereafter Del/+) and their wild-type littermates from both sexes over two or three consecutive nights during social interactions of familiar mixed-genotype quartets of males and of females, and of same-genotype unfamiliar female pairs.ResultsWe observed that Del/+ mice of both sexes increased significantly their locomotor activity compared to wild-type littermates. In the social domain, Del/+ mice of both sexes displayed widespread deficits, even more so in males than in females in quartets of familiar individuals. In pairs, significant perturbations of the organisation of the social communication and behaviours appeared in Del/+ females.DiscussionAltogether, this suggests that, over long recording periods, the phenotype of the 16p11.2 Del/+ mice was differently affected in the locomotor activity and the social domains and between the two sexes. These findings confirm the importance of testing models in long-term conditions to provide a comprehensive view of their phenotype that will refine the study of cellular and molecular mechanisms and complement pre-clinical targeted therapeutic trials.

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Section: Resultsmentioning

confidence: 99%

Day-to-day spontaneous social behaviours is quantitatively and qualitatively affected in a 16p11.2 deletion mouse model

Rusu,

Chevalier,

de Chaumont

et al. 2023

Front. Behav. Neurosci.

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show abstract

“…As the structure of behavioural events such as contacts was perturbed in Del/+ mice (see above), we investigated whether the basic organisation of the behaviour was affected by examining the temporal succession of simple behavioural events, that should contribute to a better understanding of the functions of the different behaviours (30,31). For this analysis, we needed to de ne exclusive behavioural events (i.e., events that could not occur at the same time; see methods for de nitions).…”

Section: Transitions Between Behavioural Events In Unfamiliar Pairsmentioning

confidence: 99%

A 16p11.2 deletion mouse model displays quantitatively and qualitatively different behaviours in sociability and social novelty over short- and long-term observation

Rusu

Chevalier

Chaumont

et al. 2022

Preprint

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Background Autism spectrum disorders affect more than one percent of the population, impairing social communication and increasing stereotyped behaviours. A micro-deletion of the 16p11.2 BP4-BP5 chromosomic region has been identified in one percent of patients also displaying intellectual disabilities. In mouse models generated to understand the mechanisms of this deletion, learning and memory deficits were pervasive in most genetic backgrounds, while social communication deficits were only detected in some models. Based on previous study (Arbogast et al. 2016 PLoS genetics), we selected the mouse model of 16p11.2 deletion on a hybrid C57BL/6NxC3B genetic background to itemize the social deficits. We examined whether behavioural deficits observed in short observation periods were representative of the phenotype displayed by the same mice over long-term monitoring. We recorded the individual and social behaviours of 16p11.2 Del/+ mice and their wild-type littermates from both sexes in short-term (15 min) and long-term (over two and three consecutive nights) social interactions of familiar mixed-genotype quartets of males and of females, and of same-genotype unfamiliar female pairs. Results We observed that Del/+ mice of both sexes increased significantly their activity compared to wild-type littermates only over long-term monitoring. In the social domain, Del/+ mice of both sexes displayed only limited impairments over short-term monitoring, and more visible deficits over long-term monitoring. When recorded in quartets of familiar individuals, social impairments were stronger in males than in females. In pairs, significant perturbations of the organisation of the social communication and behaviours in Del/+ females appeared mostly over the long-term. Conclusions Altogether, this suggests that social and contextual variations affect the phenotype of the 16p11.2 Del/+ mice differently in the activity and the social domains. The social behaviour was also differently affected between the two sexes. These findings confirm the importance of testing models both in short- and long-term conditions to provide a comprehensive view of their phenotype that will be more robust for pre-clinical targeted therapeutic trials.

show abstract

“…As the structure of behavioural events such as contacts was perturbed in Del/+ mice (see above), we investigated whether the organisation of the behaviour was affected by examining the temporal succession of simple behavioural events, that should contribute to a better understanding of the functions of the different behaviours (Wiltschko et al, 2015; Bels et al, 2022). For this analysis, we defined exclusive behavioural events (i.e., events that could not occur at the same time; see methods for definitions).…”

Section: Shortened Sequences and Atypical Acoustic Structure Of Ultra...mentioning

confidence: 99%

Day-to-day spontaneous social behaviours is quantitatively and qualitatively affected in a 16p11.2 deletion mouse model

Rusu

Chevalier

Chaumont

et al. 2022

Preprint

View full text Add to dashboard Cite

BackgroundAutism spectrum disorders affect more than one percent of the population, impairing social communication and increasing stereotyped behaviours. A micro-deletion of the 16p11.2 BP4-BP5 chromosomic region has been identified in one percent of patients also displaying intellectual disabilities. In mouse models generated to understand the mechanisms of this deletion, learning and memory deficits were pervasive in most genetic backgrounds, while social communication deficits were only detected in some models. Based on previous study (Arbogast et al. 2016 PLoS genetics), we selected the mouse model of 16p11.2 deletion on a hybrid C57BL/6NxC3B genetic background to itemize the social deficits. We examined whether behavioural deficits observed in short observation periods were representative of the phenotype displayed by the same mice over long-term monitoring. We recorded the individual and social behaviours of 16p11.2 Del/+ mice and their wild-type littermates from both sexes in short-term (15 min) and long-term (over two and three consecutive nights) social interactions of familiar mixed-genotype quartets of males and of females, and of same-genotype unfamiliar female pairs.ResultsWe observed that Del/+ mice of both sexes increased significantly their activity compared to wild-type littermates only over long-term monitoring. In the social domain, Del/+ mice of both sexes displayed only limited impairments over short-term monitoring, and more visible deficits over long-term monitoring. When recorded in quartets of familiar individuals, social impairments were stronger in males than in females. In pairs, significant perturbations of the organisation of the social communication and behaviours in Del/+ females appeared mostly over the long-term.ConclusionsAltogether, this suggests that social and contextual variations affect the phenotype of the 16p11.2 Del/+ mice differently in the activity and the social domains. The social behaviour was also differently affected between the two sexes. These findings confirm the importance of testing models both in short- and long-term conditions to provide a comprehensive view of their phenotype that will be more robust for pre-clinical targeted therapeutic trials.

show abstract

Studies of the Behavioral Sequences: The Neuroethological Morphology Concept Crossing Ethology and Functional Morphology

Cited by 6 publications

References 98 publications

Day-to-day spontaneous social behaviours is quantitatively and qualitatively affected in a 16p11.2 deletion mouse model

Day-to-day spontaneous social behaviours is quantitatively and qualitatively affected in a 16p11.2 deletion mouse model

A 16p11.2 deletion mouse model displays quantitatively and qualitatively different behaviours in sociability and social novelty over short- and long-term observation

Day-to-day spontaneous social behaviours is quantitatively and qualitatively affected in a 16p11.2 deletion mouse model

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