Studies of silicon nanoparticles uptake and biodegradation in cancer cells by Raman spectroscopy

Super-resolution microscopy as a powerful tool to study complex synthetic materials

“…SIM is ideally suitable to perform live-cell studies due to the good temporal resolution and the minimum illumination power required. The exact intracellular localization of different nanomaterials has been determined thanks to the high particle localization accuracy of SIM [110][111][112][113] . In addition to the exact localization of the nanomaterial, SIM enabled the motoring of its degradation over time, as fragments of 100-200 nm could be imaged.…”

Comparative analysis of stability and biological activities of violacein and starch capped silver nanoparticles

“…[8][9][10] Nanocarriers are known to not only enhance the efficacy of drugs but also maneuver its pharmacokinetics. 11 Although different kinds of nanoparticles (NPs) have been formulated, silver nanoparticles (AgNPs) outclass other NPs in terms of their potential applications ranging from household paint 12 to arti-cial prosthetic devices 13 because of their potent antimicrobial, anticancer and anti-inammatory properties. [14][15][16][17] Moreover, their synthesis is eased by using non-toxic and simple reducing agents such as glucose 18 and these AgNPs are stabilized through surface binding of capping agents, which improves stability, water solubility and also prevent aggregation.…”

Optical methods of silicon nanoparticle diagnostics for applications in biomedicine

“…In recent years, various types of nanostructured forms of crystalline silicon (Si) have been intensively studied for application in technology and biomedicine, including for the diagnosis and therapy of various diseases [1,2]. Porous Si [3,[4][5][6][7], silicon nanowires [8], and nanoparticles (NPs) obtained from them [9], as well as laser-ablated Si NPs [2,10] and nanoparticles obtained from porous c-Si [11], have a great potential of unique physical and chemical properties for application both in tumor therapy [1,2,4,9] and as contrast agents for bioimaging [8,10,11].…”

“…It was found that Si NPs can be effectively accumulated in cancer cells and therefore they be used for diagnostics and therapy of cancer [2]. It was shown that the processes of accumulation and excretion of Si NPs in biological systems can be evaluated by the Raman spectroscopy [9].…”