Optical methods of silicon nanoparticle diagnostics for applications in biomedicine

Alykova, A F; Yakunin, V. G.; Timoshenko, V. Yu.; Zavestovskaya, I. N.

doi:10.18287/jbpe19.05.020304

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Silicon nanoparticles (Si NPs), including NPs of crystalline and porous silicon, are widely researched for biomedicine applications, in particular, as active elements of biosensors and as part of new drugs for theranostics (simultaneous diagnosis and therapy) of oncological and other socially significant diseases [1][2][3][4][5][6]. If the size of crystalline NPs is less than 10 nm, they exhibit photoluminescence in the biological transparency window (650-850 nm), which can be used for their visualization in cells and tissues [7][8][9][10][11]. The large Si nanoparticles (more than 10 nm) are in turn capable of providing nonlinear biovisualization mechanisms, such as two-photon luminescence and second harmonic generation, the combination of which makes it possible to effectively track both individual silicon NPs and their aggregation in different parts of the cell, while the resolution of such approach is sufficient to obtain 3Dimages [12].…”

Section: Introductionmentioning

confidence: 99%

Measurement of Silicon Nanoparticles Temperature by Raman Spectroscopy

Alykova

Grigoryeva

Zavestovskaya

et al. 2021

J-BPE

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The temperature of silicon nanoparticles under laser photo-induced heating is determined from the ratio of the intensities of the Stokes and anti-Stokes components of the Raman scattering. The obtained results of the dependence of nanoparticles temperature on the laser radiation intensity and the temperature dependence of the Raman line position maybe used to determine the optimal regimes of photo-hyperthermia enhanced by silicon nanoparticles for cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Measurement of Silicon Nanoparticles Temperature by Raman Spectroscopy

Alykova

Grigoryeva

Zavestovskaya

et al. 2021

J-BPE

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Laser-Ablative Synthesis of Silicon–Iron Composite Nanoparticles for Theranostic Applications

et al. 2023

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The combination of photothermal and magnetic functionalities in one biocompatible nanoformulation forms an attractive basis for developing multifunctional agents for biomedical theranostics. Here, we report the fabrication of silicon–iron (Si-Fe) composite nanoparticles (NPs) for theranostic applications by using a method of femtosecond laser ablation in acetone from a mixed target combining silicon and iron. The NPs were then transferred to water for subsequent biological use. From structural analyses, it was shown that the formed Si-Fe NPs have a spherical shape and sizes ranging from 5 to 150 nm, with the presence of two characteristic maxima around 20 nm and 90 nm in the size distribution. They are mostly composed of silicon with the presence of a significant iron silicide content and iron oxide inclusions. Our studies also show that the NPs exhibit magnetic properties due to the presence of iron ions in their composition, which makes the formation of contrast in magnetic resonance imaging (MRI) possible, as it is verified by magnetic resonance relaxometry at the proton resonance frequency. In addition, the Si-Fe NPs are characterized by strong optical absorption in the window of relative transparency of bio-tissue (650–950 nm). Benefiting from such absorption, the Si-Fe NPs provide strong photoheating in their aqueous suspensions under continuous wave laser excitation at 808 nm. The NP-induced photoheating is described by a photothermal conversion efficiency of 33–42%, which is approximately 3.0–3.3 times larger than that for pure laser-synthesized Si NPs, and it is explained by the presence of iron silicide in the NP composition. Combining the strong photothermal effect and MRI functionality, the synthesized Si-Fe NPs promise a major advancement of modalities for cancer theranostics, including MRI-guided photothermal therapy and surgery.

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Optical methods of silicon nanoparticle diagnostics for applications in biomedicine

Cited by 2 publications

References 12 publications

Measurement of Silicon Nanoparticles Temperature by Raman Spectroscopy

Measurement of Silicon Nanoparticles Temperature by Raman Spectroscopy

Laser-Ablative Synthesis of Silicon–Iron Composite Nanoparticles for Theranostic Applications

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