Studies of PET nonwovens modified by novel antimicrobials configured with both<i>N</i>-halamine and dual quaternary ammonium with different alkyl chain length

Chien, Hsiu Wen; Chen, Ying-Yuan; Chen, Yen Lun; Cheng, Chi-Hui; Lin, Jui Che

doi:10.1039/c9ra00094a

Cited by 21 publications

(10 citation statements)

References 27 publications

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“…Further increase of the alkyl chain (CDs-C12) resulted in increased MIC values, owing to the capability of hydrophobic tails of adhering to one another via hydrophobic intermolecular interactions, blocking the electrostatic interactions of positively charged TAA with bacteria and diminishing the antibacterial potency. These findings are in good agreement with previous studies of relationship between alkyl length of tetraalkylammo nium salts and antibacterial activity of surface-modified materials [44][45][46][47][48][49][50].…”

Section: Antimicrobial Properties and Cytotoxicity Towards Staphyloco...supporting

confidence: 93%

Surface modification of carbon dots with tetraalkylammonium moieties for fine tuning their antibacterial activity

Sviridova

Barras

Plotnikov

et al. 2021

Preprint

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In this contribution, we report a facile functionalization method of carbon dots (CDs) by tetraalkylammonium moieties using diazonium chemistry to improve their antibacterial activity against Gram-positive and Gram-negative bacteria. CDs were modified by novel diazonium salts bearing tetraalkylammonium moieties (TAA) with different alkyl chains (C2, C4, C9, C12) for the optimization of antibacterial activity. The functionalized CDs were characterized by X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared (FTIR) spectroscopy, ultraviolet–visible (UV-vis) absorption spectrophotometry and fluorescence spectroscopy to confirm the covalent binding of TAA onto the CDs’ surface. Variation of the alkyl chain allows to reach the strongest antibacterial effect for CDs-C9 towards Gram-positive S. aureus (MIC 3.09±1.10 µg mL-1) and Gram-negative E. coli (MIC 7.93±0.17 µg mL-1) bacteria. In addition, the antibiofilm properties of the CDs-C9 were assessed; full biofilm inhibition was achieved after 6 h (64 µg mL-1) and 2 h (128 µg mL-1) treatment for S. aureus biofilm and >60% suppression of biofilm mass after 6 h (128 µg mL-1) for E. coli biofilm. CDs-C9 demonstrated good biocompatibility on mouse fibroblast (NIH/3T3), HeLa and U-87 MG cell lines for concentrations up to 256 µg mL-1. Collectively, our work highlights the correlation between the surface chemistry of CDs and their antimicrobial performance.

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Section: Antimicrobial Properties and Cytotoxicity Towards Staphyloco...supporting

confidence: 93%

Surface modification of carbon dots with tetraalkylammonium moieties for fine tuning their antibacterial activity

Sviridova

Barras

Plotnikov

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…Serial dilutions of the vortexed solutions were prepared, and 100 μL of each dilution was placed on sterile plates containing trypticase soy agar (15 g/L agar [BD, USA], 15 g/L tryptone [Cyrusbioscience, Taiwan], 5 g/L peptone [Cyrusbioscience], and 5 g/L NaCl). After incubation at 37 °C for 24 h, the number of bacterial colonies on the plate was counted to obtain the corresponding concentration of living bacteria …”

Section: Experimental Methodsmentioning

confidence: 99%

Rapid Biocidal Activity of N-Halamine-Functionalized Polydopamine and Polyethylene Imine Coatings

2021

Self Cite

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Microorganisms easily adhere to the surface of substrates and further form biofilms, which present problems in various fields. Therefore, the development of surfaces with antimicrobial adhesion or viability is a promising approach. In this study, we were committed to develop a rapid sterilizing coating. First, polyester fibers were immersed into a mixing solution of dopamine (PDA) and polyethyleneimine (PEI) for forming the co-deposition of PDA and PEI coatings. After this, the co-deposition of PDA and PEI coatings was immersed in a solution of household bleach for chlorination. We found that the nitrogens of PDA and PEI could be chlorinated repeatedly and that the oxidative chlorine content increased with the increasing PEI concentration upon co-deposition. Next, the efficacy of the co-deposition of chlorinated PDA and PEI coatings in eliminating Staphylococcus aureus and Escherichia coli was investigated. We found that the antibacterial ability of the coatings increased with increasing PEI content. In addition, the chlorinated co-deposition coatings had significantly improved antibacterial properties compared to the unchlorinated ones. The chlorinated co-deposition coatings inactivated >99.99% of S. aureus and >99.9% of E. coli after contact of less than 10 min. Therefore, chlorination of a PDA/PEI co-deposition surface is a feasible method for use in antibacterial coatings.

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“…In addition to the N -halamines that could be bonded to the fibrous substrates directly, many other substrates and N -halamines are not able to react with each other, a medium which serves as a bridge between N -halamines and fibrous materials is often required. Crosslinking agents, like 1,2,3,4-butanetetracarboxylic acid (BTCA) [ [91] , [92] , [93] , [94] , [95] , [96] , [97] ], dimethylol-5,5-dimethylhydantoin (DMDMH) [ 71 , 98 , 99 ], and citric acid [ 100 ], have been widely applied to react with N -halamines and fibers for the fabrication of NFMs due to their excellent chemical reactivity. For example, Li et al [ 101 ] attached N -halamine precursor compound, 2,2,6,6-tetramethyl piperidinol (TMP), onto cotton fabrics using BTCA as a crosslinker.…”

Section: Nfms Based On Surface Modificationmentioning

confidence: 99%

Antibacterial N-halamine fibrous materials

Wang

Huang

Zhang

et al. 2020

Composites Communications

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Studies of PET nonwovens modified by novel antimicrobials configured with bothN-halamine and dual quaternary ammonium with different alkyl chain length

Abstract: This work describes the synthesis of novel antimicrobial agents consisting of N-halamine and dual quaternary ammonium with different alkyl chain lengths and their antimicrobial applications for PET nonwovens.

Cited by 21 publications

References 27 publications

Surface modification of carbon dots with tetraalkylammonium moieties for fine tuning their antibacterial activity

Surface modification of carbon dots with tetraalkylammonium moieties for fine tuning their antibacterial activity

Rapid Biocidal Activity of N-Halamine-Functionalized Polydopamine and Polyethylene Imine Coatings

Antibacterial N-halamine fibrous materials

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