Studies of pentavalent organoarsenic, -antimony, and -bismuth halide compounds by nuclear quadrupole resonance spectroscopy

Brill, T. B.; Long, G. G.

doi:10.1021/ic50091a005

Cited by 38 publications

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“…Narrow series I–XXXVI of various complexes taken from the literature are given in Tables . The interpreting of NQR spectra on occasion involves difficulties.…”

Section: Resultsmentioning

confidence: 99%

NQR parameters of complexes and polarizability effect

Egorochkin

Кузнецова

Хамалетдинова

et al. 2012

Magnetic Reson in Chemistry

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The literature data on substituent influence on the nuclear quadrupole resonance frequencies (ν), quadrupole coupling constants (e(2) Qq ⋅ h(- 1) ), and asymmetry parameters (η) for 36 series of the H-complexes, charge-transfer complexes, transition metal complexes and other donor-acceptor complexes have been considered, using the correlation analysis. Generally the ν, e(2) Qq ⋅ h(- 1) , and η values were first established to depend on the inductive, resonance, polarizability, and steric effects of substituents. The presence or otherwise of certain effects as well as relation between their contributions are determined by the type of series. The polarizability effect owes its existence to the appearance of an excess charge on the indicator centre as a result of the complexation. The contribution of this effect ranges up to 75%.

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“…Narrow series I–XXXVI of various complexes taken from the literature are given in Tables . The interpreting of NQR spectra on occasion involves difficulties.…”

Section: Resultsmentioning

confidence: 99%

NQR parameters of complexes and polarizability effect

Egorochkin

Кузнецова

Хамалетдинова

et al. 2012

Magnetic Reson in Chemistry

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“…The pentavalent species of inorganic arsenate (AsO 4 3− ) favoured to exist in oxidised environments, as well as organic forms of As(V) have a different structure with a trigonal-bipyramidal shape where the As(V) atom is located at the centre, co-ordinating to three equatorial and two polar atoms [ 62 , 63 ]. In comparing the two different structural states of As(III) and As(V), it is not yet clear why the trivalent methylarsenic-containing compounds show a much higher toxicity than their pentavalent analogues [ 24 , 64 ].…”

Section: Cellular Actions Of Arsenic-containing Compoundsmentioning

confidence: 99%

Arsenic-Based Antineoplastic Drugs and Their Mechanisms of Action

Ralph

2008

Metal-Based Drugs

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Arsenic-based compounds have become accepted agents for cancer therapy providing high rates of remission of some cancers such as acute promyelocytic leukemia (APL). The mechanisms by which arsenic-containing compounds kill cells and reasons for selective killing of only certain types of cancer cells such as APLs have recently been delineated. This knowledge was gained in parallel with increasing understanding and awareness of the importance of intracellular redox systems and regulation of the production of reactive oxygen species (ROS) by controlling mitochondrial function. Many of the targets for the arsenic-containing compounds are mitochondrial proteins involved in regulating the production of ROS. Inhibition of these proteins by disulfide linkage of vicinal thiol groups often leads to increased production of ROS and induction of apoptotic signalling pathways. Sensitivity or resistance to the actions of arsenic-containing compounds on cancer cells and normal cells depends on the levels of transport systems for their uptake or efflux from the cells as well as their redox defence mechanisms. The exact mechanisms of arsenic toxicity as well as its anticancer properties are likely to be related and these aspects of arsenic metabolism are covered in this review. Greater understanding of the mechanisms of action of arsenic will help determine the risks of human exposure to this chemical. Novel organic arsenic-containing compounds and the lessons learned from studying their selective sensitivity in targeting dividing endothelial cells to inhibit angiogenesis raise the future possibility for designing better targeted antineoplastic arsenic-containing compounds with less toxicity to normal cells.

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“…Das fu È nfbindige Antimonatom des Tribenzyldibromstiborans (6) weist in Ûbereinstimmung mit Kernquadrupolresonanz-Untersuchungen [83] eine trigonal-bipyramidale Umgebung auf (Abb. 1 c).…”

Section: Tribenzyldibromstiboran (6)unclassified

Untersuchungen am Chlordiphenyl- und Tribenzylstiban sowie am Tribenzyldibromstiboran - Molekülstrukturen und Isotypie

Becker

Mündt

Sachs

et al. 2001

Z. anorg. allg. Chem.

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Professor Josef Goubeau in memoriamInhaltsu È bersicht. Chlordiphenylstiban (1 d) {P2 1 /c; Z = 4; a = 1191,8(1); b = 853,4(1); c = 1112,0(1) pm; b = 93,60(1)°; ±100 ± 2°C} kristallisiert isotyp zu einer Reihe homologer Verbindungen der Zusammensetzung (H 5 C 6 ) 2 E±X (E = As, X = Cl, Br, I; E = Sb, X = Br, I); der Strukturtyp des Tribenzylstibans (5 d) {Pbca; Z = 8; a = 832,1(2); b = 2681,3(5); c = 1600,9(3) pm; ±100 ± 3°C} ist vom Tribenzylmethanol, -silanol und -silan her bekannt. Demgegenu È ber weist Tribenzyldibromstiboran (6) {P2 1 /n; Z = 4; a = 938,4(2); b = 2292,4(5); c = 1019,7(2) pm; b = 112,71(1)°; ±100 ± 3°C} keine entsprechenden Beziehungen zu bereits bekannten Strukturtypen auf. Charakteristische, gemittelte Bindungsla È ngen und -winkel sind {1 d: Sb±Cl 240,9(1); Sb±C 214,0 pm; Cl±Sb±C 93,8; C±Sb±C 98,6(1)°; 5 d: Sb±C 217,5(3) pm; C±Sb±C 94,9(6)°; 6: Sb±Br 264,6; Sb±C 217,0(8) pm; Br±Sb±Br 179,4(1)°; C±Sb±C 120°; Br±Sb±C 84,8(2)°bis 94,7(2)°}. Beim Stiboran 6 deuten sich sehr schwache intermolekulare Antimon´´Brom-Wechselwirkungen (Sb´´Br 417 pm) an; sie wirken sich jedoch in auffallender Weise auf die Moleku È lkonformation aus. Element±Element Bonds. X. Studies of Chloro(diphenyl)stibane, Tribenzylstibane and Tribenzyldibromostiborane ± Molecular Structures and Isotypism Abstract. Chlorodiphenylstibane (1 d) {P2 1 /c; Z = 4; a = 1191.8(1); b = 853.4(1); c = 1112.0(1) pm; b = 93.60 (1)°; ±100 ± 2°C} crystallizes isotypically with a series of homologous (H 5 C 6 ) 2 E±X compounds (E = As, X = Cl, Br, I; E = Sb, X = Br, I); the structure type of tribenzylstibane (5 d) {Pbca; Z = 8; a = 832.1(2); b = 2681.3(5) pm; c = 1600.9(3); ±100 ± 3°C} is already known from tribenzylmethanol, -silanol and -silane. Tribenzyldibromostiborane (6) {P2 1 /n; Z = 4; a = 938.4(2); b = 2292.4(5); c = 1019.7(2) pm; b = 112.71(1)°; ±100 ± 3°C} does not show an analogous relationship to known structure types. Characteristic mean bond lengths and angles are {1 d, Sb±Cl 240.9(1), Sb±C 214.0 pm, Cl±Sb±C 93.8°, C±Sb±C 98.6(1)°; 5 d, Sb±C 217.5(3) pm, C±Sb±C 94.9(6)°; 6, Sb±Br 264.6; Sb±C 217.0(8) pm, Br±Sb±Br 179.4(1)°; C±Sb±C 120°; Br±Sb±C 84.8(2)°to 94.7(2)°}. Stiborane 6 exhibits very weak intermolecular Sb´´Br interactions of 417 pm which, however, affect the molecular conformation in a striking way.

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Studies of pentavalent organoarsenic, -antimony, and -bismuth halide compounds by nuclear quadrupole resonance spectroscopy

Cited by 38 publications

References 0 publications

NQR parameters of complexes and polarizability effect

NQR parameters of complexes and polarizability effect

Arsenic-Based Antineoplastic Drugs and Their Mechanisms of Action

Untersuchungen am Chlordiphenyl- und Tribenzylstiban sowie am Tribenzyldibromstiboran - Molekülstrukturen und Isotypie

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