Abstract:Sixteen monoclonal antibodies against antigens coded for by the RT1 complex of the rat have been produced. Fourteen arc specific for the a haplotype: six recognize class II and eight class I antigens. Two are specific for the I haplotype, one reacting with class I and the other with class II antigens. By means of these monoclonal antibodies four independent clusters of antigens for class I antigens of the a haplotype and three for class II antigens could be defined. The three antigenic sites of class II antige… Show more
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