Studies of mixed surfactant solutions of cationic dimeric (gemini) surfactant with nonionic surfactant C12E6 in aqueous medium

Sharma, K. Shivaji; Rodgers, Christopher; Palepu, R.; Rakshit, Animesh Kumar

doi:10.1016/j.jcis.2003.07.038

Cited by 101 publications

(66 citation statements)

References 41 publications

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“…Solutions of the lipid were prepared in pure water and approximately 25 ml of each solution was poured into the heating jacket and allowed to equilibrate to 37G0.58C. Surface tension measurements and CMC determinations were made using a standard method (Sharma et al 2003).…”

Section: Critical Micelle Concentration Determinationsmentioning

confidence: 99%

Testing the hypothesis that amphiphilic antineoplastic lipid analogues act through reduction of membrane curvature elastic stress

Dymond

Attard

Postle

2008

J. R. Soc. Interface.

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The alkyllysophospholipid (ALP) analogues Mitelfosine and Edelfosine are anticancer drugs whose mode of action is still the subject of debate. It is agreed that the primary interaction of these compounds is with cellular membranes. Furthermore, the membrane-associated protein CTP: phosphocholine cytidylyltransferase (CCT) has been proposed as the critical target. We present the evaluation of our hypothesis that ALP analogues disrupt membrane curvature elastic stress and inhibit membrane-associated protein activity (e.g. CCT), ultimately resulting in apoptosis. This hypothesis was tested by evaluating structure -activity relationships of ALPs from the literature. In addition we characterized the lipid typology, cytotoxicity and critical micelle concentration of novel ALP analogues that we synthesized. Overall we find the literature data and our experimental data provide excellent support for the hypothesis, which predicts that the most potent ALP analogues will be type I lipids.

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Section: Critical Micelle Concentration Determinationsmentioning

confidence: 99%

Testing the hypothesis that amphiphilic antineoplastic lipid analogues act through reduction of membrane curvature elastic stress

Dymond

Attard

Postle

2008

J. R. Soc. Interface.

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“…Temperatures were kept constant (±0.1 K) by circulating thermostated water through a jacketed vessel containing the solution. Other conditions were the same as reported in our recent papers (26,27). Representative plots of γ vs. log 10 C isotherms are shown in Figure 1.…”

Section: Methodsmentioning

confidence: 85%

“…The maximum surface excess (Γ max ) is an effective measure of adsorption at the air-water interface and was calculated by the Gibbs adsorption equation (8). Γ max was calculated from limiting area per molecule (A min ) values (26). The slope of the tangent at the given concentration of the γ vs. logC plot (i.e., dγ/dlogC) was used to calculate Γ max by fitting a curve to a polynomial of the form, y = ax 2 + bx + c in Microsoft Excel.…”

Section: Resultsmentioning

confidence: 99%

Investigation of the properties of decaoxyethylene n‐dodecyl ether, C₁₂E₁₀, in the aqueous sugar‐rich region

Sharma

Rakshit

2004

J Surfact & Detergents

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Interfacial, thermodynamic, and morphological properties of decaoxyethylene n-dodecylether [CH 3 (CH 2 ) 11 (OCH 2 CH 2 ) 10 OH] (C 12 E 10 ) in aqueous solution were analyzed by tensiometric, viscometric, proton nuclear magnetic resonance (NMR), and small-angle neutron scattering (SANS) techniques. Dynamic and structural aspects at different temperatures in the absence and presence of sugars at different concentrations were measured. Critical micelle concentrations (CMC) were determined by surface tension measurements in the presence of ribose, glucose, and sucrose. The heat capacity (∆C p.m. ), transfer enthalpy (∆H m.tr. ), transfer heat capacities (∆C p.m.tr. ), micellization constant (K m ), Setchenow constant (K S N ), and partition coefficient (q) were determined and discussed as an extension of the usual thermodynamic quantities of micellization and adsorption at the air-water interface. An enthalpy-entropy compensation effect was observed with an isostructural temperature (T c ) of about 310 K for both micellization and interfacial adsorption. SANS measurements were taken to elucidate structural information, viz., aggregation number (N agg ), shape, size, and number density (N m ) on C 12 E 10 micelles in D 2 O at different concentrations of sugars (0.05, 0.02, 0.3, and 0.5 M) and temperatures (30, 45, and 60°C). Intrinsic viscosity gave the hydrated micellar volume (V h ), volume of the hydrocarbon core (V c ), and volume of the palisade layer of the oxyethylene (OE) unit (V OE ). SANS, as well as rheological data, supported the formation of nonspherical micelles with or without sugars. By SANS, we also observed that at the studied temperature intervals, oblate ellipsoid micelles changed into prolate ellipsoids and the number density of micelles decreased with an increase in temperature both in the presence and in the absence of sugars and also on increasing the concentration of sugars. Proton NMR showed a change in chemical shift of the OE group of micelles above the CMC. We also studied the phase separation of C 12 E 10 by sugars in cloud point measurements.Paper no. S1398 in JSD 7, 305-316 (July 2004).KEY WORDS: Aggregation number, cloud point, critical micelle concentration, nonionic surfactant, small-angle neutron scattering, viscosity.Surfactant molecules self-assemble into finite-sized aggregates called micelles in aqueous solution. These are significant for their numerous uses, including solubilization, dispersion, emulsification, catalysis, and technological, biological, and pharmaceutical applications. Such aggregates are formed in various shapes, e.g., globular, ellipsoidal, cylindrical, and disk-shaped (1). The morphology of micelles depends on the chemical structure of the surfactant monomer (2) and on solution conditions such as concentration, temperature, co-surfactant, and ionic strength (3,4). Control of the morphology of these types of aggregates by the addition of external additives or by the proper choice of surfactant mixture has become increasingly important in recent years, both ...

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“…The purity of the products was confirmed by thin-layer chromatography (TLC) using 5:1 (v/v) chloroform/methanol as the solvent and iodine vapor as the visualization reagent. R f values: C 8 A 0.67, C 10 …”

Section: Methodsmentioning

confidence: 99%

Synthesis and Properties of Alkylbetaine Zwitterionic Gemini Surfactants

Xie

Feng

2009

J Surfact & Detergents

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A series of alkylbetaine zwitterionic gemini surfactants, 1,2-bis[N-methyl-N-carboxymethyl-alkylammonium]ethane (C n Ab, n = 8, 10, 12, or 14), were synthesized by alkylation of N,N 0 -dimethylethylenediamine with an alkyl bromide, followed by reaction with sodium 2-bromoacetate. Their solution properties were characterized by surface tension, steady-state fluorescence, and rheological measurements. Surface-tension measurements showed C n Ab had lower critical micelle concentration (CMC) and higher efficiency in lowering the surface tension than their corresponding monomeric surfactants. The logCMC of C n Ab decreased linearly with increasing chain lengths up to 12. Viscosity measurements showed only C 10 Ab could enhance aqueous solution viscosity at high concentrations.

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Studies of mixed surfactant solutions of cationic dimeric (gemini) surfactant with nonionic surfactant C12E6 in aqueous medium

Cited by 101 publications

References 41 publications

Testing the hypothesis that amphiphilic antineoplastic lipid analogues act through reduction of membrane curvature elastic stress

Testing the hypothesis that amphiphilic antineoplastic lipid analogues act through reduction of membrane curvature elastic stress

Investigation of the properties of decaoxyethylene n‐dodecyl ether, C₁₂E₁₀, in the aqueous sugar‐rich region

Synthesis and Properties of Alkylbetaine Zwitterionic Gemini Surfactants

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Studies of mixed surfactant solutions of cationic dimeric (gemini) surfactant with nonionic surfactant C12E6 in aqueous medium

Cited by 101 publications

References 41 publications

Testing the hypothesis that amphiphilic antineoplastic lipid analogues act through reduction of membrane curvature elastic stress

Testing the hypothesis that amphiphilic antineoplastic lipid analogues act through reduction of membrane curvature elastic stress

Investigation of the properties of decaoxyethylene n‐dodecyl ether, C12E10, in the aqueous sugar‐rich region

Synthesis and Properties of Alkylbetaine Zwitterionic Gemini Surfactants

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Investigation of the properties of decaoxyethylene n‐dodecyl ether, C₁₂E₁₀, in the aqueous sugar‐rich region