Studies of mitochondrial development during embryogenesis in the rat

Mackler, Bruce; Grace, Richard; Duncan, Helen

doi:10.1016/0003-9861(71)90367-5

Cited by 94 publications

(46 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In several species, including mouse, the mitochondria of germ cells are structured in a characteristic way [75,76], which in rat sperm cells is known to be associated with the presence of the sperm-specific lactate dehydrogenase isoenzyme [77]. These properties are also found in early embryonic stages of the rat until the 12 somite stage, when a drastic change in the regulation of pathways of energy metabolism has been shown to occur [78,79]. This embryonic stage of rat development corresponds to day 8.5 in mouse embryo development.…”

Section: Discussionmentioning

confidence: 99%

Change of Cytochrome c Structure during Development of the Mouse

Hennig

1975

European Journal of Biochemistry

View full text Add to dashboard Cite

The structure of cytochrome c during mouse development is investigated. For this purpose the amino acid sequence of cytochrome c of the adult mouse had to be determined. The structure of cytochrome c of adult differentiated mouse cells differs in two amino acid residues from the known amino acid sequence of rabbit cytochrome c. No indication of different forms of cytochrome c in the adult differentiated cells was obtained. The structure of cytochrome c from 11.5‐day‐old mouse embryos is identical with that of adult mouse tissues. Since germ cells after meiotic division are the immediate precursors of a new individual, the structure of cytochrome c from sperm‐containing mice testes was investigated. By means of chromatography of the cytochrome c and of peptide maps and amino acid analyses of its tryptic peptides, it is shown that mouse testis contains two isocytochromes c in about equal amount. The structure of one of these two isocytochromes c is identical with the structure of the adult‐type cytochrome c of mouse. The testis‐specific cytochrome c, which is assumed to be located in the sperm cells, differs in 13 of its 104 amino acid residues from the adult‐type cytochrome c. From comparison of the primary and the spatial structures of the adult‐type and the sperm‐type isocytochromes c with the known structures of cytochrome c of more than 65 different species it is concluded that the duplication of the cytochrome c structural gene, causing the existence of the two ontogenetic‐specific isocytochromes c in mouse, has occurred early in the evolution of eucaryotes.

show abstract

Section: Discussionmentioning

confidence: 99%

Change of Cytochrome c Structure during Development of the Mouse

Hennig

1975

European Journal of Biochemistry

View full text Add to dashboard Cite

show abstract

“…Rat embryo mitochondria during placentation are a suitable model to further understand mitochondrial biogenesis due to the important oxidative metabolism activation that takes place (Mackler et al 1971, Akazawa et al 1994. However, this developmental stage has not been further characterised.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial differentiation and oxidative phosphorylation system capacity in rat embryo during placentation period

Alcolea

Colom²,

Lladó³

et al. 2007

Reproduction

View full text Add to dashboard Cite

Mitochondrial biogenesis and function are essential for proper embryo development; however, these processes have not been further studied during the placentation period, when important oxidative metabolism activation is taking place. Thus, the aim of the present study was to investigate the oxidative phosphorylation system (OXPHOS) enzymatic activities as well as the expression of genes involved in the coordinated regulation of both mitochondrial and nuclear genomes (peroxisome proliferatoractivated receptor-g coactivator-1a, nuclear respiratory factors 1 and 2, mitochondrial single-strand DNA-binding protein, mitochondrial transcription factor A), and mitochondrial function (cytochrome c oxidase subunit IV, cytochrome c oxidase subunit I and b-ATP phosphohydrolase) in rat embryo throughout the placentation period (gestational days 11, 12 and 13). Our results reflect that embryo mitochondria were enhancing their OXPHOS potential capacities, pointing out that embryo mitochondria become more differentiated during the placentation period. Besides, the current findings show that the mRNAs of the nuclear genes involved in mitochondrial biogenesis were downregulated, whereas their protein content together with the mitochondrial DNA expression were upregulated throughout the period studied. These data indicate that the molecular regulation of the mitochondrial differentiation process during placentation involves a post-transcriptional activation of the nuclear-encoded genes that would lead to an increase in both the nuclear-and mitochondrial-encoded proteins responsible for the mitochondrial biogenic process. As a result, embryo mitochondria would reach a more differentiated stage with a more efficient oxidative metabolism that would facilitate the important embryo growth during the second half of the pregnancy. Reproduction (2007) 134 147-154

show abstract

“…Cu/Zn-SOD does appear earlier than Mn-SOD in the rat fetus [88], at a time when O −• 2 fluxes are at their maximum [25]. Mn-SOD and mitochondria, where Mn-SOD is strictly located, follow parallel initial appearance, inhibition or loss [89,90]. Due to the development of Cu/Zn-SOD, the very active and deleterious O −• 2 radical is dismutated into H 2 O 2 (40% decrease and 40% increase of their respective rates of production [25]).…”

Section: Mn-and Cu/zn-sod Induction and Controlmentioning

confidence: 98%

“…H 2 O 2 can then diffuse to the site of its action and is more readily a signaling molecule [7,78]. The decrease of O −• 2 concentrations in the cells can change the effects of this radical from an initial deleterious effect [89,90] into an oxidative signal [78]. Mitochondria remain functional and allow cell growth only when it is equipped with sufficient Mn-SOD to dismutate mitochondrial O −• 2 into H 2 O 2 [39].…”

Section: Mn-and Cu/zn-sod Induction and Controlmentioning

confidence: 99%

Gestation linked radical oxygen species fluxes and vitamins and trace mineral deficiencies in the ruminant

2006

View full text Add to dashboard Cite

-In mammals, radical oxygen species (ROS) are essential factors of cell replication, differentiation and growth (oxidative signal), notably during gestation, but are also potentially damaging agents. In Women, ROS play a role in remodeling of uterine tissues, implantation of the embryo, settlement of the villi and development of blood vessels characteristic of gestation. The body stores of vitamins and minerals of gestating females are used to keep ROS fluxes at a level corresponding to oxidative signals and to prevent an imbalance between their production and scavenging (oxidative stress), which would be detrimental to the mother and fetus. There is some evidence that, although based on different regulatory mechanisms, most of the effects of ROS reported in humans also occur in pregnant ruminant females, some of which have been actually reported. Many vitamins and trace elements have dual effects in the organism of mammals: (a) they are involved in the control of metabolic pathways or/and gene expression, (b) but most of the time they also display ROS trapping activity or their deficiencies induce high rates of ROS production. Deficiencies induce different disorders of gestation and can be induced by different kinds of stress. An example is given, corresponding to the decreased contents of cobalt of forages, when exposed to sustained heavy rains, so that the supply of vitamins B12 to the organism of the ruminant that grazes them is reduced and failure of gestation is induced. Outdoor exposure of ruminants to adverse climatic conditions by itself can increase the vitamin and trace element requirements. Adaptation of production systems taking into account these interactions between gestation and sources of stress or change of the quality of feeding stuffs as well as further developments of knowledge in that field is necessary to promote sustainable agricultural practices.gestation / ovine / bovine / vitamins / trace elements / antioxidant enzymes / radical oxygen species / radical phenomena

show abstract

Studies of mitochondrial development during embryogenesis in the rat

Cited by 94 publications

References 8 publications

Change of Cytochrome c Structure during Development of the Mouse

Change of Cytochrome c Structure during Development of the Mouse

Mitochondrial differentiation and oxidative phosphorylation system capacity in rat embryo during placentation period

Gestation linked radical oxygen species fluxes and vitamins and trace mineral deficiencies in the ruminant

Contact Info

Product

Resources

About