Studies of Mechanisms of the Action of Androgens on Prostate

Shida, Keiso; Shimazaki, Jun; Urano, E; Kojima, Hiroshi; Takahashi, Hirotomo; Furuya, Nobuo; Taya, Motosuke

doi:10.5980/jpnjurol1928.63.2_109

Cited by 5 publications

(1 citation statement)

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“…Chlormadinon has previously been proven to be a useful drug in the treat¬ ment of benign prostatic disease in man (Geller et al 1969;Shida et al 1972). The ultrastructural changes which have been demonstrated are similar to the alterations which have been found after castration (Dahl 8c Kjaerheim 1973;Dahl 8c Tveter 1973) and are consistent with atrophy.…”

Section: Discussionmentioning

confidence: 99%

The Ultrastructure of the Accessory Sex Organs of the Male Rat

Dahl¹,

Hars²

1975

Acta Endocrinologica

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The present paper describes the fine structure of the accessory sex organs of the male rat as seen after administration of the anti-androgenic compound chlormadinon acetate for 20 days. There was a general involution of the organs with macroscopic atrophy and reduced amount of secretory material. Ultrastructurally the cells contained less organelles as compared with the controls, loss of cytoplasm and reduction both of cell height and width. The major changes also included reduction of the Golgi areas and the rough endoplasmic reticulum. Within the dorsal lobe prominent nuclear changes were found. The alterations observed in the present study are similar to the changes which were found in rats treated with another anti-androgenic compound, Cyp A. It is concluded that these two anti \x=req-\ androgenic compounds exert their effects through similar mechanisms with a specific influence on the prostate and the seminal vesicles.

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Section: Discussionmentioning

confidence: 99%

The Ultrastructure of the Accessory Sex Organs of the Male Rat

Dahl¹,

Hars²

1975

Acta Endocrinologica

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Histological evaluation of benign prostatic hyperplasia treated by long‐term administration of chlormadinone acetate (CMA)

et al. 1994

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Although the clinical effects of attempted nonsurgical treatment of benign prostatic hyperplasia have been well documented, detailed histological evaluation of the effects of treatment appears to be limited. The effect of long-term administration of an antiandrogen, chlormadinone acetate (CMA), on benign prostatic hyperplasia was evaluated with histological comparison of two biopsy specimens, one before treatment and one after treatment. Secretory epithelium showed obvious regressive changes with occasional basal cell prominence after CMA treatment. Stromal elements, however, did not show any marked changes, except for occasional edematous loosening. Scores of multiple epithelial parameters tended to be correlated with clinical improvement in urinary obstructive symptoms, especially in patients with predominant glandular hyperplasia. These results suggest that long-term administration of the potent antiandrogen CMA to inhibit dihydrotestosterone-receptor binding might be a useful therapeutic maneuver in patients with glandular hyperplasia, without any deterioration of the stromal component.

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