1994
DOI: 10.1002/pros.2990250306
|View full text |Cite
|
Sign up to set email alerts
|

Histological evaluation of benign prostatic hyperplasia treated by long‐term administration of chlormadinone acetate (CMA)

Abstract: Although the clinical effects of attempted nonsurgical treatment of benign prostatic hyperplasia have been well documented, detailed histological evaluation of the effects of treatment appears to be limited. The effect of long-term administration of an antiandrogen, chlormadinone acetate (CMA), on benign prostatic hyperplasia was evaluated with histological comparison of two biopsy specimens, one before treatment and one after treatment. Secretory epithelium showed obvious regressive changes with occasional ba… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
18
0

Year Published

1995
1995
2010
2010

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 22 publications
(18 citation statements)
references
References 21 publications
0
18
0
Order By: Relevance
“…Chlormadinone acetate (CMA) is a steroidal antiandrogen that is widely used in the medical management of human BPH or prostatic carcinoma [9,12]. Histologically, CMA produced marked atrophy of the glandular epithelium (Tables 1, 2).…”
Section: Atrophic Effect Of Antiandrogenmentioning
confidence: 99%
“…Chlormadinone acetate (CMA) is a steroidal antiandrogen that is widely used in the medical management of human BPH or prostatic carcinoma [9,12]. Histologically, CMA produced marked atrophy of the glandular epithelium (Tables 1, 2).…”
Section: Atrophic Effect Of Antiandrogenmentioning
confidence: 99%
“…The atrophic effect of CMA on the human prostatic hyperplasia has been reported by several authors [8,11]. The antiandrogenic mechanisms of CMA has been evaluated biochemically and immunohistochemically, such as androgen receptor content, and steroid 5a-reductase type II activity in the prostate [11,[19][20][21][22].…”
Section: Introductionmentioning
confidence: 95%
“…Canine BPH is believed by many investigators to be an appropriate model for the study of human BPH, although there are important differences between the conditions in the two species [1,10,18,30,34]. Thus, the human disease is often a multinodular process thought to arise from a priurethal stromal nodule, which is then secondarily invaded by glandular elements [8]. In contrast, canine BPH is a diffuse epithelial or glandular process with less stromal involvement [4].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Canine BPH is believed by many investigators to be an appropriate model for the study of human BPH, although there are important differences between the conditions in the two species [9,30]. Thus, the human disease is often a multinodular process thought to arise from a periurethal stromal nodule, which is then secondarily invaded by the glandular elements [7]. In contrast, canine BPH is a diffuse epithelial or glandular process with less stromal involvement [4].…”
Section: Introductionmentioning
confidence: 99%