1984
DOI: 10.1203/00006450-198409000-00012
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Studies of Lipids, Lipoproteins, and Apolipoproteins in Menkes' Disease

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Cited by 12 publications
(5 citation statements)
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“…Similar effects reported in higher organisms have now been largely attributed to the redox-active nature of copper and the ability of copper to catalyze the generation of free radicals that promote membrane lipid peroxidation [67][68][69][70]. For example, Cu 2+ uniquely catalyzed peroxidation of rat erythrocyte membrane lipid in the presence of 10 mM H 2 O 2 , while several other transition metal ions had no significant effect [70].…”
Section: Copper Mediated Cell Membrane Damagementioning
confidence: 79%
“…Similar effects reported in higher organisms have now been largely attributed to the redox-active nature of copper and the ability of copper to catalyze the generation of free radicals that promote membrane lipid peroxidation [67][68][69][70]. For example, Cu 2+ uniquely catalyzed peroxidation of rat erythrocyte membrane lipid in the presence of 10 mM H 2 O 2 , while several other transition metal ions had no significant effect [70].…”
Section: Copper Mediated Cell Membrane Damagementioning
confidence: 79%
“…Lipid profiles have been explored in some patients and found affected, but inconsistently, with the exception of a higher neutral lipid content of VLDL in all tested MND patients compared to controls. Interestingly, although ApoB in patients appeared normal, it degraded faster during storage suggesting lower stability (73). Variations in lipid profiles could also be age-related.…”
Section: Lipid Metabolism In Menkes Diseasementioning
confidence: 99%
“…This eventually leads to the leakage of mobile cellular solutes, such as potassium ions, and cell death. Similar effects reported in higher organisms are now mainly due to the redox-active nature of copper and its ability to stimulate the production of free radicals that promote membrane lipid peroxidation. …”
Section: Metal Nanoparticles For Antimicrobial Finishesmentioning
confidence: 73%