Studies of H5N1 Influenza Virus Infection of Pigs by Using Viruses Isolated in Vietnam and Thailand in 2004

Choi, Young Ki; Nguyen, Trung Hai; Ozaki, Hiroichi; Webby, Richard J.; Puthavathana, Pilaipan; Buranathal, Chantanee; Chaisingh, Arunee; Auewarakul, Prasert; Hạnh, Nguyễn Thị Hồng; Kit, Sia; Hui, K.; Guan, Yi; Peiris, J. S. Malik; Webster, Robert G.

doi:10.1128/jvi.79.16.10821-10825.2005

Cited by 171 publications

(159 citation statements)

References 12 publications

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“…However, an exaggerated inflammatory response is believed to contribute to H5N1-associated morbidity and mortality [52][53][54][55]. For example, the resistance of pigs to severe H5N1-mediated disease correlated with the lack of a strong pro-inflammatory response following infection [56][57][58]. Combined with evidence that macrophages support productive replication of some IAV strains, excessive cytokine production following H5N1 infection may be a result of productive virus replication in macrophages.…”

Section: Iav Replication and Hypercytokinemiamentioning

confidence: 99%

Influenza virus replication in macrophages: balancing protection and pathogenesis

Cline

Beck

Bianchini

2017

Journal of General Virology

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Macrophages are essential for protection against influenza A virus infection, but are also implicated in the morbidity and mortality associated with severe influenza disease, particularly during infection with highly pathogenic avian influenza (HPAI) H5N1 virus. While influenza virus infection of macrophages was once thought to be abortive, it is now clear that certain virus strains can replicate productively in macrophages. This may have important consequences for the antiviral functions of macrophages, the course of disease and the outcome of infection for the host. In this article, we review findings related to influenza virus replication in macrophages and the impact of productive replication on macrophage antiviral functions. A clear understanding of the interactions between influenza viruses and macrophages may lead to new antiviral therapies to relieve the burden of severe disease associated with influenza viruses.

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Section: Iav Replication and Hypercytokinemiamentioning

confidence: 99%

Influenza virus replication in macrophages: balancing protection and pathogenesis

Cline

Beck

Bianchini

2017

Journal of General Virology

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“…The transmission of HPAIV to mammals is of great concern as it may allow adaptation to mammalian hosts, resulting in acquisition of a pandemic potential for humans. Interestingly, swine, previously thought to act as an important mixing vessel of avian and human influenza viruses, do not seem to play a significant role in the spread of HPAIV H5N1, and natural infections appear to be rare (Choi et al, 2005;Isoda et al, 2006). In this report, we have shown that (i) the viral infectious dose determines the clinical outcome of HPAIV H5N1 infection in cats, (ii) asymptomatic cats shed only minimal amounts of virus and (iii) cats can be effectively protected by vaccination against lethal HPAIV H5N1 challenge infection.…”

Section: Introductionmentioning

confidence: 99%

Protection of cats against lethal influenza H5N1 challenge infection

Vahlenkamp

Harder

Giese

et al. 2008

Journal of General Virology

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Highly pathogenic avian influenza virus (HPAIV) H5N1 of Asian origin continues to circulate in poultry and wild birds, causing considerable concern for veterinary and public health in Asia, Europe and Africa. Natural transmission of HPAIV H5N1 from poultry to humans, resulting in infections associated with high mortality, and from poultry or wild birds to large felids and domestic cats has been reported. Experimental infection of cats with HPAIV H5N1 derived from a human patient resulted in lethal disease. The role of cats in the adaptation of HPAIV H5N1 to mammals and vaccination regimens for the eventual protection of cats, however, remain to be elucidated. Here, it was shown that cats can be protected against a lethal high-dose challenge infection by an inactivated, adjuvanted heterologous H5N6 avian influenza virus vaccine. The challenge HPAIV H5N1 was derived from a naturally infected cat. In non-vaccinated cats, low-dose exposure resulted in asymptomatic infections with minimal virus excretion. As diseased cats can transmit the infection to naïve contact animals, the epidemiological role of H5N1-infected cats in endemically infected areas as a link between wild birds, poultry and humans needs close inspection, and vaccination of cats should be considered to reduce possible human exposure.

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“…This possibility increases the potential public health threat of H5N1 HPAI. Since its emergence in domestic geese in Guangdong Province, China (6,7), the H5N1 HPAI virus has evolved to form at least 10 distinct phylogenetic clades (8) and has spread to wild migratory waterfowl (9) and to multiple mammalian hosts (10)(11)(12)(13)(14)(15)(16). In April 2005, a massive die-off of wild waterfowl was caused by H5N1 HPAI viruses at Qinghai Lake in China (17,18).…”

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confidence: 99%

Puzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry

Kim

Kayali

Walker

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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In Egypt, efforts to control highly pathogenic H5N1 avian influenza virus in poultry and in humans have failed despite increased biosecurity, quarantine, and vaccination at poultry farms. The ongoing circulation of HP H5N1 avian influenza in Egypt has caused >100 human infections and remains an unresolved threat to veterinary and public health. Here, we describe that the failure of commercially available H5 poultry vaccines in Egypt may be caused in part by the passive transfer of maternal H5N1 antibodies to chicks, inhibiting their immune response to vaccination. We propose that the induction of a protective immune response to H5N1 is suppressed for an extended period in young chickens. This issue, among others, must be resolved and additional steps must be taken before the outbreaks in Egypt can be controlled.

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Studies of H5N1 Influenza Virus Infection of Pigs by Using Viruses Isolated in Vietnam and Thailand in 2004

Abstract: To determine whether avian H5N1 influenza viruses associated with human infections in

Cited by 171 publications

References 12 publications

Influenza virus replication in macrophages: balancing protection and pathogenesis

Influenza virus replication in macrophages: balancing protection and pathogenesis

Protection of cats against lethal influenza H5N1 challenge infection

Puzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry

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