Studies of carotenoid one-electron reduction radicals

Edge, Ruth; El‐Agamey, Ali; Land, Edward J.; Navaratnam, S.; Truscott, T. George

doi:10.1016/j.abb.2006.10.008

Cited by 30 publications

(31 citation statements)

References 20 publications

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“…Though in the present study the reduced form of antioxidant could not be detected because of the rapid reaction with other species present in the medium, Galano et al suggested the AOx-reduced form for the antioxidant reaction as intermediate species (Edge, El-Agamey, Land, Navaratnam, & Truscott, 2007;Galano, Vargas, & Martinez, 2010). We hypothesised that antioxidant's electron acceptance capacity may be expressed in terms of DE À E 1=2 ðoxÞ, where DE is transition energy obtained from the absorption band in the UV region (Dodsworth & Lever, 1986;Okuno, Kita, Kashiwabara, & Fujita, 1989).…”

Section: No-scavenging Rate and Mechanismmentioning

confidence: 56%

Nitric oxide (NO) scavenging capacity of natural antioxidants

et al. 2011

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Section: No-scavenging Rate and Mechanismmentioning

confidence: 56%

Nitric oxide (NO) scavenging capacity of natural antioxidants

et al. 2011

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“…The retina's antioxidant system operates in a highly integrated manner (Lien and Hammond, 2011;Hammond and Lien, 2013;Edge et al, 2007) to protect both aqueous and lipid-soluble components. Vitamin E (in its natural bioavailable form) is an efficient chain-breaking lipid-soluble antioxidant in membranes and plays an essential role in minimizing the oxidation of LCPUFAs.…”

Section: Prevention Of Ocular Photodegradation Through Endogenous Andmentioning

confidence: 99%

Oxidative photodegradation of ocular tissues: Beneficial effects of filtering and exogenous antioxidants

Hammond

Johnson

George

2014

Experimental Eye Research

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The fact that light is necessary for life is generally accepted as an axiom. The extent to which light interacts and influences human biology, however, is often not fully appreciated. Exposure to sunlight, for instance, can both promote and degrade human health. There is now general scientific consensus that, although the eye evolved to respond to light, it is also damaged by excessive exposure. Light-mediated ocular damage is involved in the pathophysiology of many common forms of blindness. The type of ocular tissue damage induced by light exposure depends on the extent of exposure and wavelength. The tissues of the lens, cornea, and retina contain specific chemical moieties that have been proven to exhibit light-mediated oxidative degradation. Proteins and lipids present in the cornea, lens, and retina, meet all of the physical requirements known to initiate the process of oxidative photodegradation upon exposure to solar radiation. As such, different mechanisms have evolved in the lens, cornea, and retina to ameliorate such light-mediated oxidative damage. It appears, however, that such mechanisms are ill-matched to handle modern conditions: namely, poor diet and longer life-spans (and the degenerative diseases that accompany them). Hence, steps must be taken to protect the eye from the damaging effects of light. Preventative measures include minimizing actinic light exposure, providing exogenous filtering (e.g., through the use of protective lenses), and enhancing antioxidant defenses (e.g., through increased dietary intake of antioxidants). These strategies may yield long-term benefits in terms of reducing oxidative photodegradation of the ocular tissues.

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“…[9] So far, electron uptake by Car has been investigated by quite elaborated methods: chemical reactions with metals (Al-Hg, Na, K, Cs), [10][11][12][13] and metal organic compounds (e.g. sBuLi), [14] electrochemical methods, [15] ionizing rays (pulse radiolysis) [2,16,17] and flash photolysis. [18] Notwithstanding, electron transfer to Car should be possible without relying on particular scrupulous procedures.…”

Section: ·-mentioning

confidence: 99%

“…[1] The reverse reaction, uptake of electrons by Car (oxidant reaction ) has not yet been observed in nature and is therefore not considered relevant for the antiradical properties of carotenoids. [2] Literally understood, Car are antioxidants for reactive oxygen species, inter alia hydroxy radical HO · , peroxyl radical HO 2…”

Section: Introductionmentioning

confidence: 99%