Studies in vitamin A. 19. Preparation and properties of retinene2

Cama, H. R.; Dalvi, Pooja; Morton, R. A.; Salah, M. K.; Steinberg, Gunther; Stubbs, A. L.

doi:10.1042/bj0520535

Cited by 41 publications

(20 citation statements)

References 8 publications

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“…1. Filled circles, from preparations obtained by reduction of retinene2 (3-dehydroretinal) in vivo; plain circles, from preparations reduced by the Pondorff method in vitro; dotted curve from preparations reduced by lithium aluminium hydride; crosses, vitamin A2 from fish liver oil, according to CAMA, DALVI, MORTON, and SALAH (1952). Filled circles, from preparations obtained by reduction of retinene2 (3-dehydroretinal) in vivo; plain circles, from preparations reduced by the Pondorff method in vitro; dotted curve from preparations reduced by lithium aluminium hydride; crosses, vitamin A2 from fish liver oil, according to CAMA, DALVI, MORTON, and SALAH (1952).…”

Section: Wovelengthin Nmmentioning

confidence: 99%

“…The spectral absorbance in ethanol of vitamin A2 (3-dehydroretinol) from several sources, the mean being given by the continuous curve. (CAMA, DALVI, MORTON, SALAH, STEINBERG, and STUBBS, 1952) (CAMA, DALVI, MORTON, SALAH, STEINBERG, and STUBBS, 1952) …”

Section: Wovelengthin Nmmentioning

confidence: 99%

“…However, the two vitamins yielded mixtures of the corresponding aldehydes on standing in light petroleum over manganese dioxide, and it proved possible to separate the aldehydes by chromatography (CAMA, DALVI, MORTON, and SALAH, 1952;CAMA, DALVI, MORTON, SALAH, STEINBERG, and STUBBS, 1952). However, the two vitamins yielded mixtures of the corresponding aldehydes on standing in light petroleum over manganese dioxide, and it proved possible to separate the aldehydes by chromatography (CAMA, DALVI, MORTON, and SALAH, 1952;CAMA, DALVI, MORTON, SALAH, STEINBERG, and STUBBS, 1952).…”

Section: A the Retinenes And Their Relation To The Vitamins Amentioning

confidence: 99%

“…Pure retinene 2 was reduced by the Ponndorf method and also by the use of lithium aluminium hydride, and vitamin A2 was obtained in practically the pure state (CAMA, DALVI, MORTON, SALAH, STEINBERG, and STUBBS, 1952). The structure of vitamin A2 is, Fig.…”

Section: A the Retinenes And Their Relation To The Vitamins Amentioning

confidence: 99%

“…The Origins and Biogenesis of the livers of Scardinius and most other freshwater fishes, however, contain in addition to retinol appreciable quantities of the 3-dehydro derivative (cf-EDISBURY, MOR'roN, and SIMPKINS, 1937;EDISBURY, MORTON, SIMPKINS, and LOVERN, 1938;LEDERER, ROSANOVA, GILLAM, and HEILBRON, 1937;WALD, 1939a;MORTON and CREED, 1939;CAMA, DALVI, MORTON, SALAH, STEINBERG, and STUBBS, 1952), which may account for nearly 100 % of the liver retinols in some cases (Fig_ 32)_ A little-publicised finding is the widespread occurrence of 3-dehydroretinol in marine fish-liver oils also, often amounting to between 4 and 20 % ofthe total "vitamins A" (COLLINS, '" u MORTON and CREED, 1939;COLLINS, LOVE, and MORTON, 1953;GROSS and BUDOWSKI, 1966), and hence the only dietary source would be other fishes. The Origins and Biogenesis of the livers of Scardinius and most other freshwater fishes, however, contain in addition to retinol appreciable quantities of the 3-dehydro derivative (cf-EDISBURY, MOR'roN, and SIMPKINS, 1937;EDISBURY, MORTON, SIMPKINS, and LOVERN, 1938;LEDERER, ROSANOVA, GILLAM, and HEILBRON, 1937;WALD, 1939a;MORTON and CREED, 1939;CAMA, DALVI, MORTON, SALAH, STEINBERG, and STUBBS, 1952), which may account for nearly 100 % of the liver retinols in some cases (Fig_ 32)_ A little-publicised finding is the widespread occurrence of 3-dehydroretinol in marine fish-liver oils also, often amounting to between 4 and 20 % ofthe total "vitamins A" (COLLINS, '" u MORTON and CREED, 1939;COLLINS, LOVE, and MORTON, 1953;GROSS and BUDOWSKI, 1966), and hence the only dietary source would be other fishes.…”

Section: F Origins and Biogenesis Of The 3-dehydroretinol Prostheticmentioning

confidence: 99%

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Photochemistry of Vision

Abrahamson¹,

Baumann²,

Bridges³

et al. 1972

Handbook of Sensory Physiology

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Section: Wovelengthin Nmmentioning

confidence: 99%

Section: Wovelengthin Nmmentioning

confidence: 99%

Section: A the Retinenes And Their Relation To The Vitamins Amentioning

confidence: 99%

Section: A the Retinenes And Their Relation To The Vitamins Amentioning

confidence: 99%

Section: F Origins and Biogenesis Of The 3-dehydroretinol Prostheticmentioning

confidence: 99%

See 3 more Smart Citations

Photochemistry of Vision

Abrahamson¹,

Baumann²,

Bridges³

et al. 1972

Handbook of Sensory Physiology

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Recent Advances in Nutrition and Metabolism

Unglaub¹

1954

AMA Arch Intern Med

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A SMALL monograph entitled "Present Knowledge in Nutrition" has been published recently.1 This should prove a most useful reference ; sections dealing with calories, protein, fat, carbohydrate, minerals, and vitamins are included. VITAMIN A Cama and associates * reported further studies of the characteristics of vitamin A and related compounds. Kaiser and Kagan 6 have described a technique for the determination of vitamin A in feces.Prolonged administration of quinacrine (Atabrine) to rats was found to result in damage to the liver and impairment of the ability of this organ to store vitamin A. Absorption of vitamin A and carotene was depressed by the drug.7The administration of excessive amounts of vitamin A to rats and other animals accelerates the growth and maturation of epiphyseal cartilage cells and the remodeling process which accompanies bone growth. Such effects are suggestive of hormonal action, possibly that of the anterior pituitary. However, studies by Wolbach and Maddock 8 in hypophysectomized rats have shown that these effects occur in the absence of the pituitary and in spite of marked atrophy of the adrenal glands. Similar effects have been observed upon the addition of excessive amounts of vitamin A to the medium containing tissue culture of bone from chick embryos.9 The changes observed in tissue culture are qualitatively similar to those seen in animals made hypervitaminotic by feeding large amounts of vitamin A.f The use of tissue culture techniques appears to offer distinct advantages in the study of the effects of vitamin A upon tissues.14 An unusual case of vitamin A deficiency in a 5 J^-month-old infant was reported by Cornfeld and Cooke.15 Facial palsy and increased intracranial pressure observed in this patient might possibly be attributed to compression of tissues of the growing central nervous system by failure of normal growth of the axial skeleton, which has been observed in various mammalian species and, more recently, in the chicken and duck.| weeks. Definite beneficial effects of this therapy upon localized conjunctival thickening, blepharoconjunctivitis, and "toad skin" were observed. Follicular hyperkeratosis of the forearms persisted in five of eight patients, and improvement in dark adaptation was observed in only 4 of 17 subjects. Kaser and associates 1T reported that patients with a sprue-like syndrome showed no increase in serum vitamin A levels after oral administration of the vitamin given in either the ester or the alcohol form. Patients with chronic pancreatic disease showed no change in serum levels of the vitamin after administration of its ester form, but they were found to have an increase in serum vitamin A after administra¬ tion of the alcohol form.Steigmann and co-workers 18 confirmed the previously reported interference with absorption of vitamin A by mineral oil given close to mealtimes. However, the usual therapeutic dose (30 cc.) of the oil given at bedtime was without effect upon plasma vitamin A levels.Kagan and Kaiser 19 found high concentrations of v...

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Physiologic Chemistry of the Eye

Sallmann¹

1953

AMA Arch Ophthalmol

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Studies in vitamin A. 19. Preparation and properties of retinene2

Cited by 41 publications

References 8 publications

Photochemistry of Vision

Photochemistry of Vision

Recent Advances in Nutrition and Metabolism

Physiologic Chemistry of the Eye

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