Studies in chronic allergic bronchopulmonary aspergillosis. 1. Clinical and physiological findings.

Pulmonary eosinophilia with and without allergic bronchopulmonary aspergillosis.

“…In Britain the three essential criteria have generally been asthma, pulmonary eosinophilia, and a positive immediate skinprick test response to an extract of A fumigatus.22' 23 In the United States, however, serum precipitating antibodies to aspergillus antigens, a raised serum total IgE concentration, and when possible the appearance of proximal bronchiectasis on a bronchogram would also be required. 24 In this study we chose to modify the UK criteria by insisting on the additional presence of either serum precipitating antibodies to A fwnigatus or A fwnigatus in the sputum as a positive skinprick test response alone may simply be a manifestation of atopy.…”

Eosinophilic Pneumonias

“…Central bronchiectasis is associated with ABPA, though its presence on CT scan is not highly sensitive for a diagnosis of ABPA (149). Pulmonary function testing usually shows an obstructive pattern for patients with ABPA (102,124). Though pathology is not necessary for diagnosis, findings are variable, with eosinophilic inflammation, mucoid impaction, and bronchocentric granulomatosis (20,151,178).…”

Reversible airway obstruction in cystic fibrosis.

“…*Significantly greater than atopic group I p > 0 05 tSignificantly greater than atopic group 2 p > 0 05 tNot significantly different from atopic group 2 p > 0 95 Table 4 Variation of type I skin test to A fumigatus with age Age(yr) 5 gillosis. 16 Reactions to A fumigatus did not occur as an isolated positive skin test, but gave a type 1 skin reaction more commonly than any other allergen tested. There was no significant reversibility in the non-atopic group.…”