Studies concerning Swedish ropy milk

Nilsson, Bagnar; Nilsson, Gerda

doi:10.1007/bf00409978

Cited by 26 publications

(23 citation statements)

References 3 publications

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“…The present fmdings confirm earlier observations that treatment of the premature lung with PEEP leads to increased lung compliance (28). Most probably, the mechanism is here similar to that operating in surfactant-treated animals, i.e., the continuous positive pressure keeps the alveoli open throughout the ventilatory cycle, and resistance to aeration due to capillarity in finer conducting airways is thereby avoided.…”

Section: Discussionsupporting

confidence: 90%

“…Alveoli already open do not require a prolonged inspiration phase to expand, nor do already stabilized alveoli require a short expiration phase to remain patent. This explains why surfactant-treated animals could be well ventilated with a low peak pressure and a short inspiration phase, and why bronchiolar epithelial lesions-the equivalent of early hyaline membrane disease (29,36)-were usually absent in animals receiving surfactant. In the artificially ventilated surfactant-deficient lung, such lesions seem to result from shear forces in the bronchiolar mucosa, secondary to overexpansion of bronchioles and uneven expansion of terminal airspaces during the ventilatory cycle (30).…”

Section: Discussionmentioning

confidence: 99%

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Combined Effects of Surfactant Substitution and Prolongation of Inspiration Phase in Artificially Ventilated Premature Newborn Rabbits

et al. 1982

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SummaryPremature newborn rabbits, delivered by hysterotomy on day 27 of gestation, were tracheotomized at birth, kept in body plethysmographs, and subjected to pressure-generated ventilation at a working pressure of 25 cm H 20, 100% O2, and frequency 40/min. Thirty-seven animals received 50 ttl of heterologous surfactant (phospholipid content 40 mg/ml) via the tracheal cannula before onset of artificial ventilation, eight were ventilated with a positive end-expiratory pressure (PEEP) of 6 cm H 20, and 44 served as controls. All animals were ventilated in a randomized sequence of 2-min periods with 20, 40, 60, or 80% inspiration time. After the experiment the trachea was clamped at end-inspiration and the lungs fixed by immersion in formalin. Plethysmograph recordings of tidal volume revealed that lung-thorax compliance was low in control animals, even at inspiration time 80% (mean ± S.E. = 0.17 ± 0.03 mIlcm H 20.kg). In animals treated with surfactant or PEEP, compliance was significantly improved at all ventilator settings. The highest mean compliance values, obtained at 60% inspiration time were 0.91 ± 0.07 and 0.73 ± 0.14 mIlcm H 20 .kg in surfactant-and PEEP-treated animals, respectively. Compliance of surfactant-treated animals was significantly higher than that of PEEP-treated animals at inspiration time 40% (0.85 ± 0.07 versus 0.52 ± 0.13 mIlcm H20. kg; P < 0.05). The relative volume of the alveolar compartment, determined morphometrically in histologic sections and expressed as the alveolar expansion index (la), was significantly higher in surfactant-treated animals than in controls (1.60 ± 0.12 versus 0.74 ± 0.06; P < 0.005), but not improved in animals ventilated with PEEP. In animals receiving surfactant, la increased with the duration of the inspiration phase, from 0.99 ± 0.10 at 20% to 1.95 ± 0.22 at 80% inspiration time. There was also histologic evidence of enhanced recruitment of aerated alveoli in surfactant-treated animals ventilated with prolonged inspiration time. SpeculationThe air expansion of the premature neonatal lung can be enhanced to a significant degree by treatment with surfactant in combination with appropriate prolongation of the inspiration phase. Such a therapeutic regimen might be useful in the management of newborn infants with severe respiratory distress syndrome, requiring artificial ventilation; however, because excessive prolongation of the inspiration phase could have adverse effects on pulmonary hemodynamics and lead to hypoventilation with respiratory acidosis, the setting of the ventilator should be carefully adjusted with respect to the therapeutic response in patients with respiratory distress syndrome who are treated with supplementary surfactant. 921

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Combined Effects of Surfactant Substitution and Prolongation of Inspiration Phase in Artificially Ventilated Premature Newborn Rabbits

et al. 1982

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“…The polypeptides in this layer include those of the chlorophyll a antennae, CP47 and CP43, the chlorophyll a/b antenna, CP29, a 10 kDa polypeptide and several minor components. Removal of the 22 and 10 kDa polypeptides has little effect on the kinetics of water oxidation, but the fact that the 22 kDa polypeptide is found in PSII ofall plants examined [13], and also in PSII of Synechocystis 6803 [15], suggests that it must have some role in PSII function or assembly. Its amino acid sequence indicates that the 22 kDa protein is a highly hydrophobic protein, with four potential membrane-spanning regions.…”

Section: Febs Le'i~fers December 1992mentioning

confidence: 99%

Characterization of a spinach psbS cDNA encoding the 22 kDa protein of photosystem II

et al. 1992

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An intrinsic 22 kDa polypeptide is found associated with the oxygen-evolvin~ photosystem 11 (PSII) core complex in all green plants and cyanobaeteria so far examined, although it does not appear to be required l'or oxygen evolution. Amino acid ~equenee itfforrnation obtained from the purified 22 kDa protein was used to construct a probe that was employed to isolate a full-length eDNA clone encoding the 274-residue precursor of the 22 kDa protein. Hydropathy plot analysis predicts the existence of four membrane-spanning helices in the mature protein, The two halves of the approxlmntely 200-resld uc mature protein show high sequence similarity to each other, suggesting that the psbS gene arose from an internal gene duplication. The 22 kDa protein has some sequence similarity to chlorophyll a/b.binding proteins.

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“…and ionic strength 4 M; the first through fourth (from M+3) for ace tate complexes of La+3, Ce+3, Nd+3, and Gd+ a by Sonesson (100) potentio metrically at 20°e. and ionic strength 2 M; 5 X 1012 for Ag(S20a)2-a, 3 X 1013 for Ag(S20a)a-s, 2 X 10 2 6 for Ag 2 (S20a)4-6 by Nilsson (101) (111) have calcu lated renormalization factors (differing from unity by 2 per cent or less) to be applied to "best" values of l' previously given by Stokes (112). The meth od is based on the use of empirical equations for activity and osmotic co efficients containing the same two empirical constants and is checked with McLeod & Gordon's (113) activity coefficient data for CaCI2• By treating new or previously measured diffusion coefficients in a previously described (132) have calculated the change with solvent composition of the standard chemical potential of NaCI in a dioxane-water mixture by using thermodynamic relations derived for this purpose.…”

mentioning

confidence: 99%

“…and ionic strength 2.0 1vI; 7. 2 for TIS20a-, 5.2 for Tl(S203)2-3, 1.5 for Tl(S20a)a-5 (all from TI+) by Nilsson (99) using two methods at 25°e. and ionic strength 4 M; the first through fourth (from M+3) for ace tate complexes of La+3, Ce+3, Nd+3, and Gd+ a by Sonesson (100) potentio metrically at 20°e.…”

mentioning

confidence: 99%

Solutions of Electrolytes

Poirier¹

1959

Annu. Rev. Phys. Chem.

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Due to limitations of both space and time, the reviewer has restricted the scope of the following review, omitting certain subjects which might properly be included. Notable among these are: solutions of electrolytes in molten metals and salts, solutions of polyelectrolytes and soaps, solutions of chelate complexes, phase studies with water as one component, ion exchange, elec trode processes, and nuclear magnetic resonance. These topics are left to reviews, under other titles, appearing at least occasionally in the Annual Review of Physical Chemistry.The reviewer does not disguise his enthusiasm for theoretical work, especially that with a statistical mechanical flavor.The most recent discussion of The Faraday Society, Interaction in Ionic Solutions (1), has been published. In this one volume a number of very sig nificant and stimulating articles are contained or discussed. Most of the papers are mentioned individually below. EQUILIBRIUM PROPERTIESTheory.-During the past year, considerable progress has been made in this field. Falkenhagen & Kelbg (2) have briefly reviewed recent work in the statistical theory of ionic solutions and have presented a derivation of the relation between the potential of average force and the mean electrostatic potential employed in the Debye-Huckel theory.A new theory which, for I-I electrolytes, has been carried through to a comparison with osmotic coefficient data is due to Moller (3). The starting point is the Born-Green integral equation in the multicomponent form previ ously presented by Kelbg & Moller (4). The Kirkwood superposition approxi mation is contained in the initial integral equations; other limitations are introduced while solving the equations, a process which contains some novel features. The initial equations are integral equations for the potential of average force,

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Studies concerning Swedish ropy milk

Cited by 26 publications

References 3 publications

Combined Effects of Surfactant Substitution and Prolongation of Inspiration Phase in Artificially Ventilated Premature Newborn Rabbits

Combined Effects of Surfactant Substitution and Prolongation of Inspiration Phase in Artificially Ventilated Premature Newborn Rabbits

Characterization of a spinach psbS cDNA encoding the 22 kDa protein of photosystem II

Solutions of Electrolytes

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