Struma Ovarii Associated with Pseudo-Meigs' Syndrome and Elevated Serum CA 125

Struma Ovarii with Pseudo-Meigs’ Syndrome and Raised Cancer Antigen-125 Levels Masquerading as an Ovarian Carcinoma: Case report and literature review

“…[2][3][4][5]9,11,12,15,[17][18][19][20][21][22]24,25 Only three patients underwent conservative surgery. 13,14,23 In the present case, the patient underwent conservative surgery in the form of a salpingo-oophorectomy, as there was no evidence of malignancy according to the frozen section analysis.…”

“…Most of the diagnosed patients were in their fifth decade or older, with the exception of one patient who was 31 years old. 11 The tumour sizes ranged between 4-23 cm in the greatest dimension, with an average size of 12 cm. 10 In all cases, the volume of ascitic fluid was over 1 L, except for five cases.…”

“…10 The mean follow-up period was approximately 8 months, ranging from 1-36 months. 4,5,[9][10][11]15,17,18,20,[22][23][24][25] Most cases were treated via total abdominal hysterectomy and bilateral of colloid-filled follicles of various sizes, resembling thyroid follicles [ Figures 3B and C]. Based on analysis of the scrape smears and frozen section, a provisional diagnosis of struma ovarii was made.…”

An unusual variant of malignant struma ovarii

“…Its atypical presentation can rarely mimic a typical ovarian carcinoma. Many cases of stuma ovarii have been reported with elevated CA-125 level, ascites and hydrothorax (pseudo-Meig syndrome) [3,4,5,6,7,8]. Only one case has shown malignant thyroid tissue and it has been reported as the first malignant struma ovarii patient with pseudo-Meig syndrome and elevated CA-125 [5].…”

Struma ovarii associated with hyperthyroidism, elevated CA 125 and pseudo‐Meigs syndrome may mimic advanced ovarian cancer

“…The association of struma ovarii with high titers of CA 125 is also rare, with only a few cases described recently in the literature 7 -9 . The fact that struma ovarii may actually mimic an ovarian carcinoma, considering the clinical features of a prevalently solid ovarian mass and high titers of CA 125, has already been reported 8,9 . In particular, as far as ultrasound imaging is concerned, the large size of the mass, its prevalently solid echostructure, the irregular walls and the low-resistance blood flow are all features seen more frequently in malignant than in benign ovarian lesions 10 ; this has led to the inclusion of struma ovarii in a group of ovarian masses that are considered difficult to characterize on ultrasound examination, even when carried out by an expert 10 .…”