Struma ovarii associated with hyperthyroidism, elevated CA 125 and pseudo‐Meigs syndrome may mimic advanced ovarian cancer

Hashimoto Thyroiditis as a Manifestation of Struma Ovarii

“…[7][8][9] Only 5% to 15% of patients with struma ovarii have features of hyperthyroidism. 3,6,11 Hyperthyroidism due to HT, histologically and clinically demonstrable in the thyroid tissue of ovarian teratoma, has been documented only in 2 cases, both without symptoms and signs due to primary thyroid disease. 10 Hyperthyroidism and struma ovarii particularly in association with the Graves' disease of the thyroid are rare.…”

Association of Pseudo-Meigs’ Syndrome with Struma Ovarii and High CA125 Mimicking Ovarian Malignancy

“…8,10 Its frequency in ovarian neoplasms is less than 1%. 2,7 Peak incidence occurs between and 5th and 6th decades of life, and only 5% of these tumors comprise hyperthyroidism. 3,5,6,8,10 This is the most common type of monodermic teratoma, with a frequency of 3% among all ovarian teratomas.…”

“…1,5,7,12,18,19 PMS associated with struma ovarii and accompanied by a rise in Ca125 is very rare: only eight cases have been reported in the medical literature to date (Table 1). [2][3][4]7,8,11,12,18,19 The possible causes of the increase of Ca125 in Meigs' syndrome include irritation of the mesothelial cells by the ovarian tumor, ascites, or pleural effusion, which leads to the antigen being released onto the surface of the serous membranes or the peritoneum. 7,16,18,19 To date, no correlation has been found among volume of ascites fluid volume, tumor size, or the value of Ca125 in Meigs' syndrome.…”

“…[2][3][4]7,8,11,12,18,19 The possible causes of the increase of Ca125 in Meigs' syndrome include irritation of the mesothelial cells by the ovarian tumor, ascites, or pleural effusion, which leads to the antigen being released onto the surface of the serous membranes or the peritoneum. 7,16,18,19 To date, no correlation has been found among volume of ascites fluid volume, tumor size, or the value of Ca125 in Meigs' syndrome. 5 What has been observed is that in Meigs' syndrome, Ca125 values are much lower that those typically found in ascites originating from malignant tumors.…”

Struma Ovarii associated with Pseudo-Meigs Syndrome and elevated serum Ca 125: Case report and literature review

“…12 In the literature, very few reports have been published on Struma Ovarii associated with ascites and elevated CA125. [13][14][15] Due to the low frequency of the tumor and its clinical and histopathological features, the case of a 72-year-old female patient with pleural effusion, ascites, right ovary tumor, elevation of Ca 125, hyperthyroidism, of urgencies in General Hospital Naval of High Specialty; this in order to carry out a review of the published literature.…”