Structures of filum terminale and characteristics of ependymal cells of its central canal in rats

Nakano, Norihiko; Kanekiyo, Kenji; Yamada, Yoshihiro; Tamachi, Masahiro; Suzuki, Yoshihisa; Fukushima, M.; Saito, Fukuki; Abe, Seiya; Tsukagoshi, Chihiro; Chimi, Miyamoto; Idé, Chizuka

doi:10.1016/j.brainres.2018.11.038

Cited by 2 publications

(4 citation statements)

References 32 publications

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“…In contrast to occlusion in humans, studies demonstrate patency of the CC in rats, which functions as a channel for CSF outflow. In rats, the CC directly receives CSF from the fourth ventricle and excretes it into the blood via the terminal filament and cauda equina [ 30 - 32 ]. The CC’s role in syringomyelia remains hypothetical due to a lack of methods to selectively occlude the CC without spinal cord injury in animals.…”

Section: Discussionmentioning

confidence: 99%

“…Physiological differences between rats and humans likely underlie the distinct CC functions. In rats, the CC remains patent, comprising an integral pathway for CSF circulation from the ventricles through the cauda equina/conus into the bloodstream [ 32 ]. In contrast, little is known regarding normal human CC function.…”

Section: Discussionmentioning

confidence: 99%

“…In rats, the CC directly receives CSF from the fourth ventricle and excretes it into the blood via the terminal filament and cauda equina. [30][31][32] The CC's role in syringomyelia remains hypothetical due to a lack of methods to selectively occlude the CC without spinal cord injury in animals. Here, we examined CC morphology and CSF flow.…”

Section: Occlusion Is Correlated With Syringomyelia Occurrencementioning

confidence: 99%

“…In rats, the CC remains patent, comprising an integral pathway for CSF circulation from the ventricles through the cauda equina/conus into the bloodstream. 32 In contrast, little is known regarding normal human CC function. Numerous histological findings and morphometric analysis of human CC have been published in the past few decades.…”

Section: Clinical Relevancementioning

confidence: 99%

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The Physiological Occlusion of the Central Canal May Be a Prerequisite for Syringomyelia Formation

Jiang,

Wang,

et al. 2023

Neurospine

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Objective: Syringomyelia is a common central nervous system disease characterized by the dilation of the central canal (CC). Regarding the pathogenesis of syringomyelia, cerebrospinal fluid (CSF) circulation obstruction in the subarachnoid space (SAS) of the spinal cord has been widely accepted. However, clinical and animal studies on obstructing the CSF in SAS failed to form syringomyelia, challenging the theory of SAS obstruction. The precise pathogenesis remains unknown.Methods: We utilized an extradural compression rat model to investigate the pathogenesis underlying syringomyelia. Magnetic resonance imaging enabled detection of syringomyelia formation. To assess CSF flow within the SAS, Evans blue was infused into the cisterna magna. Histological analysis allowed morphological examination of the CC. Furthermore, CSF flow through the CC was traced using Ovalbumin Alexa-Flour 647 conjugate (OAF-647). Scanning electron microscopy (SEM) enabled visualization of ependymal cilia.Results: The findings showed that the dura mater below the compression segment exhibited lighter coloration relative to the region above the compression, indicative of partial obstruction within the SAS. However, the degree of SAS occlusion did not significantly differ between syringomyelia (SM-Y group) and those without (SM-N group). Intriguingly, hematoxylin and eosin staining and CSF tracing revealed occlusion of the CC accompanied by reduced CSF flow in the SM-Y group compared to SM-N and control groups. SEM images uncovered impairment of ependymal cilia inside the syringomyelia.Conclusion: CC occlusion may represent a physiological prerequisite for syringomyelia formation, while SAS obstruction serves to initiate disease onset. The impairment of ependymal cilia appears to facilitate progression of syringomyelia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%