Structured Development Approach for Amorphous Systems

Page, Susanne; Maurer, Reto; Wyttenbach, Nicole; Ditzinger, Felix

doi:10.1007/978-3-030-88719-3_8

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2023

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“…Numerous polymer types and grades thereof are available for amorphous solid dispersion (ASD) developers. Each new API candidate requires a new ranking of the optimal polymer for the ASD formulation, either via experimental screenings of the API/polymer combinations or via in-silico tools ( Page et al, 2022 ; Matić et al, 2020 ). This procedure aims at finding the optimal polymer candidate for the individual API, with optimal API load in the polymer, an optimal manufacturing process and conditions thereof, and also optimal dissolution performance.…”

Section: Introductionmentioning

confidence: 99%