Structure Retention and Water Stability of Microwave Plasma Polymerized Films From Allylamine and Acrylic Acid

Finke, Birgit; Schröder, Karsten; Ohl, A.

doi:10.1002/ppap.200930305

Cited by 54 publications

(57 citation statements)

References 29 publications

(67 reference statements)

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“…Plasma polymers containing primary amino groups are known to show aging effects, i.e. oxidation reactions yielding the formation of amides (among other functional groups) [11,13,14]. Immersion in water results in weight loss and removal of nitrogen groups from the residual deposit, e.g., by hydrolysis of imine groups.…”

Section: Resultsmentioning

confidence: 99%

“…Degradation effects such as oxidation and leaching of low molecular weight fragments that are known to occur for amino-functional plasma polymers, however, require special handling [9,[11][12][13][14][15][16]. Prior to cell attachment a-C:H:N-coated samples are therefore stored in air for several weeks, thermally treated (in vacuum) and/or washed with solvents, while the media is frequently exchanged during cell growth [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Considering the degradation effects of amino-functional plasma polymer coatings for biomedical application

Hegemann¹,

Hanselmann²,

Guimond³

et al. 2014

Surface and Coatings Technology

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Materials for biomedical applications typically involve surface engineering. Scaffolds used for tissue engineering, for example, require a surface functionalization in order to support cell growth. The deposition of functional plasma polymer coatings seems to be an attractive approach to modify substrates for biomedical applications. Possible degradation of highly functional plasma polymers and the effect of its degradation products on cell growth, however, are not yet investigated in detail. Plasma polymer formation is governed by gas phase (mainly determining the chemical composition) and surface processes (inducing cross-linking) which both influence the incorporation of amino groups in a-C:H:N coatings deposited by NH 3 /C 2 H 4 discharges. Aging is studied in air and in aqueous conditions revealing the degradation of such plasma polymers (loss in thickness and loss of amino groups). Degradation products seem to influence viability and proliferation of mouse skeletal muscle cells on electrospun poly(ε-caprolactone) scaffolds. Thus, possible chemical changes as a function of time or exposure to different media must be taken into account in the design of functional plasma polymer coatings for biomedical applications in order to avoid possible adverse effects on cell growth.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Considering the degradation effects of amino-functional plasma polymer coatings for biomedical application

Hegemann¹,

Hanselmann²,

Guimond³

et al. 2014

Surface and Coatings Technology

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show abstract

“…In the second region (Figure 1), the presence of carboxylic group vibrational peaks (at 1754 cm -1 and 1734 cm -1 associated to n(C=O) ester and n(C=O) carboxylic acid) was observed (Dreesen 2007, Finke 2009, Salmain 2006. The peak intensity/area varied following the trend:…”

Section: Although the Variations Highlighted Inmentioning

confidence: 93%

Reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials

Volcke

Gandhiraman

Gubala

et al. 2010

Biosensors and Bioelectronics

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Functionalization of the plastic chips for selective immobilization of biomolecules is one of the key challenges to be addressed in commercialization of the next-generation point-of-care (POC) diagnostics devices. Multistep liquid-phase deposition process requires a large quantity of solvent to be used in anhydrous conditions, providing quantity of industrial liquid waste. We, in this work, have demonstrated a solventless plasma-based process that integrates low-cost, high throughput, high reproducibility and ecofriendly process for the functionalization of POC device platforms. Amine functionalities have been deposited by plasma-enhanced chemical vapour deposition 2 (PECVD) using a new precursor. For a successful and efficient plasma functionalization process, an understanding of the influence of plasma process parameters on the surface characteristics is essential. The influence of the plasma RF power and the deposition time on the deposited amount of amino functionalities and on their capacity to immobilize nano-objects (i.e., nanoparticles) and biomolecules (i.e. DNA) was examined. Surfacial properties were related to the binding capacity of the films and to the amino content, as revealed by the Ònanoparticle approachÓ and DNA attachment experiments. The key process determinants were to have a sufficient power in the plasma to activate and partially fragment the monomer but not too much as to lose the reactive amine functionality, and sufficient deposition time to develop a reactive layer but not to consume or erode the amine reactivity. An immunoassay performed using human immunoglobulin (IgG) as a model analyte shows an improvement of the detection limit by two orders of magnitude beyond that obtained using devices activated by liquid-phase reaction.

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“…Some examples include permanent hydrophilic treatments of textiles or contact lenses and the formation of carboxylated surfaces which can serve as platforms for the immobilization of bioactive molecules for biointerfaces (in which case already low densities of functional groups are sufficient). [1][2][3][4][5] Although acrylic acid is often used as monomer for plasma polymerization, mixtures of hydrocarbons with carbon dioxide might show some advantages. [6,7] Experimental series using hydrocarbon monomers show a complex behaviour of the deposition rate as a function of the energy input, where often a drop in deposition rate is reported at higher plasma energies.…”

Section: Introductionmentioning

confidence: 99%

Growth Mechanism of Oxygen-Containing Functional Plasma Polymers

Hegemann

Körner

Albrecht

et al. 2010

Plasma Processes Polym.

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Structure Retention and Water Stability of Microwave Plasma Polymerized Films From Allylamine and Acrylic Acid

Cited by 54 publications

References 29 publications

Considering the degradation effects of amino-functional plasma polymer coatings for biomedical application

Considering the degradation effects of amino-functional plasma polymer coatings for biomedical application

Reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials

Growth Mechanism of Oxygen-Containing Functional Plasma Polymers

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