Structure–radical scavenging activity relationships of flavonoids

Seyoum, Ameha; Asres, Kaleab; El-Fiky, Fathy K.

doi:10.1016/j.phytochem.2006.07.002

Cited by 368 publications

(260 citation statements)

References 24 publications

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“…Additionally, this substitution profile also rules the conformational behaviour of the systems, namely their flexibility, the formation of hydrogen bonds -either intra-or intermolecularly -and the preference for planar or skewed relative orientations of the substituent groups. Therefore, the beneficial activity of the flavones and isoflavones under study relies on their structural and conformational behaviour [34][35][36]. Besides determining biological activity, these strict structure-activity relationships (SAR's) modulate the systemic distribution and bioavailability of the compounds within the cell.…”

Section: Introductionmentioning

confidence: 99%

A conformational study of hydroxyflavones by vibrational spectroscopy coupled to DFT calculations

Machado

Carvalho

Otero

et al. 2013

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. The conformational preferences of a series of hydroxyflavones were studied by Raman and FTIR spectroscopies, coupled to Density Functional Theory calculations. Special attention was paid to the effect of hydroxyl substitution, due to its importance on the biological activity of these compounds. Their conformational preferences were found to be determined mainly by the orientation of the hydroxylic groups at C 7 and within the catechol moiety, leading to the occurrence of distinct conformers in the solid state. A complete assignment of the experimental spectra was carried out for these molecules, in the light of their most stable conformers and the corresponding predicted vibrational pattern.

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Section: Introductionmentioning

confidence: 99%

A conformational study of hydroxyflavones by vibrational spectroscopy coupled to DFT calculations

Machado

Carvalho

Otero

et al. 2013

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…The hydroethanol fraction afforded also the sugar 2-O-methyl-chiro-inositol. The antioxidant effects observed for ethyl acetate and hydroethanol fractions are probably due the presence of kaempferol, since the DPPH free radical activity of this flavonoid has been reported in the literature (Seyoum et al, 2006). …”

Section: Resultsmentioning

confidence: 60%

Free radical scavenging and anti-edematogenic activities of Paullinia elegans Cambess., Sapindaceae, leaves extracts

Guimarães¹,

Truitti²,

Bersani-Amado³

et al. 2010

Rev. bras. farmacogn.

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“…It was interesting to check if there are any correlations between AA and HOMO (highest occupied orbital) energies. The HO-MO orbitals and map of the electrostatic potential were calculated using semiempirical AM1 method (HyperChem™ Release 8.0.7) using optimization conditions described in the literature (Lien et al 1999;Seyoum et al 2006). The results are presented in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Comparative Analysis of Antioxidative Activity of Flavonoids Using HPLC–ED and Photometric Assays

et al. 2013

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The present investigation reports on the application of a new antioxidant activity assay for the examination of flavonoids. It has been shown that the high-performance liquid chromatography with electrochemical detection (HPLC-ED) measurements allow to obtain additional information about the antioxidative properties of pure compounds by measuring their half-wave potential, the chromatographic peak height, and the product of the peak height and exponent of potential. In comparison to the classical electrochemical measurements, the HPLC-ED is characterized by a much smaller detection limit. The results were compared with the standard photometric measurement based on 1,1-diphenyl-2-picrylhydrazyl radicals. The possible antioxidant activity forecasting is also discussed.

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Structure–radical scavenging activity relationships of flavonoids

Cited by 368 publications

References 24 publications

A conformational study of hydroxyflavones by vibrational spectroscopy coupled to DFT calculations

A conformational study of hydroxyflavones by vibrational spectroscopy coupled to DFT calculations

Free radical scavenging and anti-edematogenic activities of Paullinia elegans Cambess., Sapindaceae, leaves extracts

Comparative Analysis of Antioxidative Activity of Flavonoids Using HPLC–ED and Photometric Assays

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