Structure prediction of the entire proteome of monkeypox variants

Zheng, Lihe; Meng, Jintao; Lin, Mingzhi; Lv, Rui; Cheng, Hongxi; Zou, Lixin; Sun, Junlin; Li, Linxian; Ren, Ruobing; Wang, Sheng

doi:10.15212/amm-2022-0017

Cited by 15 publications

(16 citation statements)

References 13 publications

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“…Berthet et al, (2021), demonstrou em um estudo que o gene IL-1β, presente no clado do Congo, produz uma proteína que impede a ligação da IL-1 ao seu receptor. A IL-1, com destaque para o subtipo IL-1β, está envolvida na resposta inflamatória durante do MPV pelo fato de a ligação aos receptores de IL-1 ativarem diversas vias de sinalização imunológica (ZHENG et al, 2022). Isso pode ajudar a explicar a diferença de virulência observada entre dois clados do MPV (BERTHET et al, 2021).…”

Section: Fisiopatologiaunclassified

Doenças infecciosas: inovações e aprendizados para área médica

2023

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CERONI, Dimitri et al. Osteoarticular infections in young children: what has changed over the last years?. Swiss medical weekly, v. 144, p. w13971, 2014. KROGSTAD P.et al. Osteomielite. In: Feigin e Cherry's Textbook of Pediatric Infectious Diseases, 8ª ed. Elsevier, Filadélfia. p.516, 2018. KROGSTAD, P.; PHILLIPS, William A. Hematogenous osteomyelitis in children: management. UpToDate Online.[web-based textbook]. Baron EL (ed), UpToDate, Waltham, MA, 2019. KRZYSZTOFIAK, Andrzej et al. Italian consensus on the therapeutic management of uncomplicated acute hematogenous osteomyelitis in children. Italian journal of pediatrics, v. 47, n. 1, p. 1-12, 2021. LE SAUX, Nicole. Diagnosis and management of acute osteoarticular infections in children. Paediatrics & Child Health, v. 23, n. 5, p. 336-343, 2018. MCNEIL, J. Chase et al. Clinical and microbiologic variables predictive of orthopedic complications following Staphylococcus aureus acute hematogenous osteoarticular infections in children. Clinical Infectious Diseases, v. 69, n. 11, p. 1955-1961, 2019. MCNEIL, J. Chase. Acute hematogenous osteomyelitis in children: clinical presentation and management. Infection and drug resistance, v. 13, p. 4459, 2020. DE MESY BENTLEY, Karen L. et al. Evidence of Staphylococcus aureus deformation, proliferation, and migration in canaliculi of live corti-tanto, por mais que seja uma doença amplamente conhecida, sempre será uma síndrome que exige cuidado e atenção em sua abordagem, haja vista o impacto que teve na história da medicina ao longo dos anos e que permanece tendo. Deve ser dada sempre a devida atenção à prevenção da doença, bem como seus aspectos clínicos e sociais, buscando cada vez mais formas de tratamento.Além disso, torna-se inegável a participação do Sistema Único de Saúde em diagnosticar, prevenir, informar, notificar e servir de apoio para o contexto da Aids, comprovando que o Brasil, de maneira geral, tem tomado diversas medidas que tem tornado eficaz sua diminuição, que é evidenciada estatisticamente e pela queda de 18,7% dos casos nos últimos anos.

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Section: Fisiopatologiaunclassified

Doenças infecciosas: inovações e aprendizados para área médica

2023

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“…The generation of whole proteome datasets is done from the genomic sequence of the strain of interest of the Mpox virus. The proteome is analysed for protein sequence homology with known proteins and also to identify conserved domains in the different strains of MpoxV [18]. Once the protein(s) of interest are identified, structure prediction is carried out as the structures of only some of the Mpox viral proteins are available.…”

Section: Biology Of Mpox Virusmentioning

confidence: 99%

Insights into the challenging multi-country outbreak of Mpox: a comprehensive review

Bhat,

Saha,

Garg

et al. 2023

Journal of Medical Microbiology

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Human monkeypox virus (hMpoxV) is of zoonotic origin and is closely related to the once-dreaded smallpox virus. It is largely endemic to the African continent but has moved out of the endemic regions as sporadic clusters in the past 20 years, raising concerns worldwide. Human Mpox is characterized by a mild to severe, self-limiting infection, with mortality ranging from less than 1% to up to 10% during different outbreaks caused by different clades of MpoxV. Bushmeat hunting is one of the primary reasons for its transmission from animals to humans. Various international and national health regulatory bodies are closely monitoring the disease and have laid down guidelines to manage and prevent hMpox cases. Emergency Use Status has been granted to Tecovirimat and Brincidofovir to treat severe cases and vaccination with the smallpox vaccine is recommended for high-risk group individuals. Strategies to repurpose and discover novel therapeutics and vaccines to control the outbreak are being researched. The current Mpox outbreak that has mainly affected men as approximately 96% of all cases are reported in men, is probably the result of a complex intersection of various factors. This necessitates a strong One Health response coordination involving human, animal and environmental health institutions. This review is an attempt to provide an all-inclusive overview of the biology, history, epidemiology, pathophysiology, diagnosis and management of hMpox in context to the recent 2022–2023 multi-country outbreak which is termed by WHO a ‘Public Health Emergency of International Concern (PHEIC)’.

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“…Monkeypox virus belongs to the family Poxviridae, genus Orthopoxvirus. Poxviruses are the largest and most complex group of DNA viruses among all animal viruses [24]. Monkeypox virus is 200-300 nm in size, round brick-shaped or ovoid, and surrounded by a 30-nm outer membrane composed of irregularly shaped tubules.…”

Section: Biological Characteristicsmentioning

confidence: 99%

Unusual global outbreak of monkeypox: what should we do?

et al. 2022

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Recently, monkeypox has become a global concern amid the ongoing COVID-19 pandemic. Monkeypox is an acute rash zoonosis caused by the monkeypox virus, which was previously concentrated in Africa. The re-emergence of this pathogen seems unusual on account of outbreaks in multiple nonendemic countries and the incline to spread from person to person. We need to revisit this virus to prevent the epidemic from getting worse. In this review, we comprehensively summarize studies on monkeypox, including its epidemiology, biological characteristics, pathogenesis, and clinical characteristics, as well as therapeutics and vaccines, highlighting its unusual outbreak attributed to the transformation of transmission. We also analyze the present situation and put forward countermeasures from both clinical and scientific research to address it.

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Structure prediction of the entire proteome of monkeypox variants

Cited by 15 publications

References 13 publications

Doenças infecciosas: inovações e aprendizados para área médica

Doenças infecciosas: inovações e aprendizados para área médica

Insights into the challenging multi-country outbreak of Mpox: a comprehensive review

Unusual global outbreak of monkeypox: what should we do?

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