Structure, physicochemical and biological properties of new complex salt of aqua-(nitrilotriacetato-N,O,O′,O″)-oxidovanadium(IV) anion with 1,10-phenanthrolinium cation
“…The C–O bond lengths of nta (Table 2) confirm a one-and-a-half character of the bonds, caused by the delocalization of the π electrons of the carboxylate groups involved in the coordination of V(IV). The other vanadium–oxygen bond distances in the investigated compound are comparable with those found for its phenanthroline analogue, [phenH][VO(nta)(H 2 O)](H 2 O) 0.5 (Tesmar et al 2015). Fig.…”
Section: Resultssupporting
confidence: 76%
“…Recently, it has been proven in one specific case that the cation formed by a protonation of N-heterocyclic compound (i.e. phenH) is able to stabilize mononuclear [VO(nta)(H 2 O)] − species (Tesmar et al 2015). In this paper this finding is also confirmed for other protonated N-heterocyclic compound, i.e.…”
Section: Resultsmentioning
confidence: 99%
“…The synthesis was carried out by a method similar to that previously used for the preparation of the phenanthrolinium salt (Tesmar et al 2015). Thus, the mixture of VO(acac) 2 (2.65 g) and H 3 nta (1.91 g) in water (40 mL) was refluxed for ca.…”
Section: Methodsmentioning
confidence: 99%
“…The subject of our continuous interest are polycarboxylate vanadium coordination compounds since it has been found that they are able to scavenge superoxide free radicals (O 2 ·− ) as well as protect the HT22 hippocampal neuronal cell line against an oxidative damage (Tesmar et al 2015; Wyrzykowski et al 2013, 2015a, b). The participation of the oxidovanadium(IV) compounds in leveling of reactive oxygen and nitrogen species (RONS) suggests that vanadium compounds can be beneficial in the treatment of several diseases and malfunctions related to RONS imbalances (Pessoa et al 2015b).…”
The use of protonated N-heterocyclic compound, i.e. 2,2′-bipyridinium cation, [bpyH+], enabled to obtain the new nitrilotriacetate oxidovanadium(IV) salt of the stoichiometry [bpyH][VO(nta)(H2O)]H2O. The X-ray measurements have revealed that the compound comprises the discrete mononuclear [VO(nta)(H2O)]− coordination ion that can be rarely found among other known compounds containing nitrilotriacetate oxidovanadium(IV) moieties. The antitumor activity of [bpyH][VO(nta)(H2O)]H2O and its phenanthroline analogue, [phenH][VO(nta)(H2O)](H2O)0.5, towards human osteosarcoma cell lines (MG-63 and HOS) has been assessed (the LDH and BrdU tests) and referred to cis-Pt(NH3)2Cl2 (used as a positive control). The compounds exert a stronger cytotoxic effect on MG-63 and HOS cells than in untransformed human osteoblast cell line. Thus, the [VO(nta)(H2O)]− containing coordination compounds can be considered as possible antitumor agents in the osteosarcoma model of bone-related cells in culture.Electronic supplementary materialThe online version of this article (doi:10.1007/s10534-017-0001-6) contains supplementary material, which is available to authorized users.
“…The C–O bond lengths of nta (Table 2) confirm a one-and-a-half character of the bonds, caused by the delocalization of the π electrons of the carboxylate groups involved in the coordination of V(IV). The other vanadium–oxygen bond distances in the investigated compound are comparable with those found for its phenanthroline analogue, [phenH][VO(nta)(H 2 O)](H 2 O) 0.5 (Tesmar et al 2015). Fig.…”
Section: Resultssupporting
confidence: 76%
“…Recently, it has been proven in one specific case that the cation formed by a protonation of N-heterocyclic compound (i.e. phenH) is able to stabilize mononuclear [VO(nta)(H 2 O)] − species (Tesmar et al 2015). In this paper this finding is also confirmed for other protonated N-heterocyclic compound, i.e.…”
Section: Resultsmentioning
confidence: 99%
“…The synthesis was carried out by a method similar to that previously used for the preparation of the phenanthrolinium salt (Tesmar et al 2015). Thus, the mixture of VO(acac) 2 (2.65 g) and H 3 nta (1.91 g) in water (40 mL) was refluxed for ca.…”
Section: Methodsmentioning
confidence: 99%
“…The subject of our continuous interest are polycarboxylate vanadium coordination compounds since it has been found that they are able to scavenge superoxide free radicals (O 2 ·− ) as well as protect the HT22 hippocampal neuronal cell line against an oxidative damage (Tesmar et al 2015; Wyrzykowski et al 2013, 2015a, b). The participation of the oxidovanadium(IV) compounds in leveling of reactive oxygen and nitrogen species (RONS) suggests that vanadium compounds can be beneficial in the treatment of several diseases and malfunctions related to RONS imbalances (Pessoa et al 2015b).…”
The use of protonated N-heterocyclic compound, i.e. 2,2′-bipyridinium cation, [bpyH+], enabled to obtain the new nitrilotriacetate oxidovanadium(IV) salt of the stoichiometry [bpyH][VO(nta)(H2O)]H2O. The X-ray measurements have revealed that the compound comprises the discrete mononuclear [VO(nta)(H2O)]− coordination ion that can be rarely found among other known compounds containing nitrilotriacetate oxidovanadium(IV) moieties. The antitumor activity of [bpyH][VO(nta)(H2O)]H2O and its phenanthroline analogue, [phenH][VO(nta)(H2O)](H2O)0.5, towards human osteosarcoma cell lines (MG-63 and HOS) has been assessed (the LDH and BrdU tests) and referred to cis-Pt(NH3)2Cl2 (used as a positive control). The compounds exert a stronger cytotoxic effect on MG-63 and HOS cells than in untransformed human osteoblast cell line. Thus, the [VO(nta)(H2O)]− containing coordination compounds can be considered as possible antitumor agents in the osteosarcoma model of bone-related cells in culture.Electronic supplementary materialThe online version of this article (doi:10.1007/s10534-017-0001-6) contains supplementary material, which is available to authorized users.
“…Oxidovanadium(IV) complexes are the subject of interest to many research groups since it has been found that they reveal an interesting biological activity. Much attention has been focused on studies of their insulin‐mimetic (‐enhancing) properties, the anticancer properties as well as the cytoprotective activity against an oxidative damage . However, the main challenge in designing new oxidovanadium(IV) complexes for the future use in medicine is the selection of the appropriate type of ligands in order to overcome the balance existing between the therapeutic action and adverse effects exerted by vanadium compounds by shifting this balance toward the beneficial side.…”
The crystal structure of a nitrilotriacetate (nta) oxidovanadium(IV) salt with 4-methylpyridinium cation, [4-Me(Py)H] + , of [4-Me(Py)H][VO(nta)(H 2 O)] stoichiometry was determined. The complex comprises a discrete mononuclear [VO(nta)(H 2]coordination entity that can be rarely found among other known compounds containing nitrilotriacetate oxidovanadium(IV) moieties. The complex was characterized by spectroscopic (IR and EPR) methods, magnetic measurements, and thermogravimetry (TG-FTIR). The stability of the title compound in aqueous solutions was investigated by using the potentiometric titration method. Furthermore, spectrophotometric (UV/Vis) studies have revealed that the compound is capable to scavenge the
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