Structure Parameter Correlation of some Quinoxaline Derivatives through IR and ¹³C NMR Spectra

Abstract

A series of 6-substituted quanoxaline derivatives have been synthesized and examined their purities by literature method. The infrared and 13 C NMR spectral data of these quinoxalines were correlated with Hammett substituent constants, F and R parameters using single and multi-regression analysis. From the results of statistical analysis, the effect of substituents on the spectral frequencies has been studied.

Spectral LFER Studies on Some Sydnone Chalcones

“…The general structure of (E)-4-(N-(4-cinnamoylphenyl)sulfamoyl)-3-(p-tolyl)-1,2,3-oxadiazol-3-ium-5-olates are shown in Fig.1. [13][14][15][16][20][21][22][23][24][25][26][27][28][29][30][31]of these data with Hammett substituent constants and Swain-Lupton's [33] parameters. In this correlation, the Hammett equation was taken in the form as(1).…”

“…The Chemical shifts (δ, ppm) of vinyl protons, NH and methyl protons of synthesised sydnone chalcones were presented in Table 3. These chemical shifts(δ, ppm) have been correlated with Hammett substituent constants, F and R parameters using single and multi-linear regression analysis [13][14][15][16][20][21][22][23][24][25][26][27][28][29][30][31][32]. In this correlation the Hammett equation was taken in the form as (20) δ = ρσ + δ o (20) where δ o is the frequency for the parent member of the series.…”

“…Thirunarayanan and his co-workers have studied the effect of substituents on spectral data of some oxazine-2-amines [26]. The spectral correlation of infrared and carbon-13 NMR data of quinoxaline and phenazine derivatives were studied by Thirunaryanan et al [27,28]. Senbagam et al, have studied the effects of substituents on some substituted (E)-N-benzylidene-4H-1,2,4-triazol-4-amines [29].…”

Effect of Substituents on Phenazine Derivatives by Spectral Studies

“…These chemical shifts were correlated with Hammett substituent constants, F and R parameters using single and multi-regression analysis [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. In these correlations, the Hammett equation was taken in the form as, δ = δ 0 + ρσ (2) Where δ 0 is the chemical shift of the corresponding parent compound.…”

“…Sathiyendiran et al [34] have prepared some 2-oxopropy diazenyl benzoic acids and studied the spectral correlation. Recently Thirunarayanan et al have studied the spectral qsar study of phenazine derivatives [35]. There was no spectral correlation study was reported with phenazine molecules in the past.…”