Structure of the right testis of sexually mature genetically female fowl experimentally masculinized during embryonic life and submitted to a posthatching left castration

Maraud, R; Vergnaud, O; Rashedi, M

doi:10.1016/0016-6480(87)90031-1

Cited by 14 publications

(6 citation statements)

References 10 publications

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“…It has also been elucidated that elongated spermatids and sperm carrying the W-chromosome from chickens sex reversed by using a non-steroidal aromatase inhibitor possess fertilizing ability similar to normal male sperm carrying the Z-chromosome [20]. In sex reversal experiments using left ovariectomy with the combination of extraembryonic testis grafting and chemical treatment, varying results in the degree of sex reversal or masculinization have been reported [21,22]. Considering the various reports of sex reversal experiments, it has never been reported whether strain preferences or the genetic background of the experimental animals are a contributing factor in the degree of sex reversal of the female chicken.…”

Section: Discussionmentioning

confidence: 99%

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Differential Development of Sex-related Characters of Chickens from the GSP and PNP/DO Inbred Lines after Left Ovariectomy

Valdez

Mizutani

Kinoshita

et al. 2010

Journal of Reproduction and Development

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Abstract. To elucidate strain differences in the sex reversal of genetic females to phenotypic males, GSP and PNP/DO females were left ovariectomized (ovx) between one to three days after hatching, and the degree of masculinization based on sex-related characters, histological analysis of the right gonad and hormone assay were assessed at one year of age. The GSP and PNP/DO inbred lines were both derived from the Fayoumi breed and are only differentiated based on the red blood cell antigen type carried by each inbred line. Combs and wattles were found to be significantly bigger (P<0.05) in the GSP ovx compared with the PNP/DO ovx chickens, although male plumage patterns were more pronounced in the PNP/DO ovx. Spurs were observed both in the GSP and PNP/DO ovx chickens with no significant difference (P>0.05) in length compared with the respective male controls, and body weight was not significantly different (P>0.05) compared with the female controls. The weight of the right gonad was significantly heavier (P<0.05) in the GSP ovx than in the PNP/DO ovx. Positive correlations were found in the sex-related characters as well as the plasma testosterone level and right gonad weight in both the GSP and PNP/DO ovx chickens, but not in the spur length, which showed a negative correlation in the PNP/DO ovx chickens. Histological analysis revealed that the right gonads of the PNP/DO ovx chickens were morphologically developed compared with the GSP ovx chickens, which showed more advance stages of spermatogenesis. It could be inferred that PNP/DO females that exhibit a hereditary persistent right oviduct are more responsive to the masculinizing effect of ovariectomy compared with GSP females, suggesting that genetic background may have a possible contribution to the degree of masculinization and subsequent development of sex related characters.

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Section: Discussionmentioning

confidence: 99%

“…These lines are highly inbred and histocompatible [10]. Both lines were derived from the Fayoumi breed and differentiated on the basis of the red blood cell type antigen carried by each of the inbred lines (GSP -B 21 and PNP/DO -B 1 ) [10][11][12].…”

Section: Chicken Inbred Linesmentioning

confidence: 99%

Differential Development of Sex-related Characters of Chickens from the GSP and PNP/DO Inbred Lines after Left Ovariectomy

Valdez

Mizutani

Kinoshita

et al. 2010

Journal of Reproduction and Development

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“…Primordial germ cells (PGCs) are surrounded by these somatic cells and therefore further develop into primary sex cords (Romanoff, 1960;Stahl and Carlon, 1973;McCarrey and Abbott, 1979). Like mammalian gonads, chicken embryonic gonads consist of two layers, the outer cortex and inner medulla (Maraud et al, 1987;Clinton, 1998;Clinton and Haines, 2001;Smith and Sinclair, 2004). Development of the primary sex cords differs in the two sexes: embryonic ovaries develop from the cortex, while the testes develop from the medulla (Romanoff, 1960;McCarrey and Abbott, 1979;Maraud et al, 1987).…”

Section: Gonadogenesis and Left-right Asymmetry Of Embryonic Gonadsmentioning

confidence: 99%

“…Like mammalian gonads, chicken embryonic gonads consist of two layers, the outer cortex and inner medulla (Maraud et al, 1987;Clinton, 1998;Clinton and Haines, 2001;Smith and Sinclair, 2004). Development of the primary sex cords differs in the two sexes: embryonic ovaries develop from the cortex, while the testes develop from the medulla (Romanoff, 1960;McCarrey and Abbott, 1979;Maraud et al, 1987). In developing testes, cell division in the medulla is faster than that in the cortex leading to the thinning of the cortex in male gonads and vice versa (Romanoff, 1960;McCarrey and Abbott, 1979;Clinton, 1998).…”

Section: Gonadogenesis and Left-right Asymmetry Of Embryonic Gonadsmentioning

confidence: 99%

Left-Right Asymmetry in Chicken Embryonic Gonads

Intarapat

Stern

2014

J. Poult. Sci.

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Avian embryos have reproductive organs with unique characteristics. In female, the gonads develop asymmetrically: the left gonad generates a functional ovary, whereas the right gonad and associated embryonic oviduct (Müllerian duct) regress. In males, however, both left and right gonads develop into testes. Recent evidence, however, revealed that left-right asymmetry can be detected in both sexes. Even male embryos have a greater number of germ cells in the left gonad. Moreover, pluripotency-associated markers, as well as SSEA1, the surface antigen that is strongly expressed in chick embryonic stem cells, also show asymmetric expression in both sexes both in germ cells and in stromal cells of the gonad. This review provides an update of the state of the field.

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“…Salzgeber et al (1981) improved the masculinizing effects of ovariectomy by pretreating the embryo with tamoxifen, which interferes with binding of estrogen to estrogen receptors. Maraud et al (1987) further improved the effects of ovariectomy by additional testis grafting. They transplanted testes of 13-day-old embryos into 3-day-old female host embryos and treated the hosts with tamoxifen the next day.…”

Section: Sex Reversalmentioning

confidence: 99%