Structure of the lymphoid organs of elasmobranchs

Zapata, A.; Torroba, M.; Sacedón, Rosa; Varas, Alberto; Vicente, Ángeles

doi:10.1002/(sici)1097-010x(19960601/15)275:2/3<125::aid-jez6>3.0.co;2-f

Cited by 46 publications

(36 citation statements)

References 48 publications

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“…Immunopositivity cells for TGF 1 were observed more frequently in the epigonal organ than in the Leydig organ, and considering the findings of other researchers who have studied the histophysiological relationship between the two organs (Lundblad et al, 1979;Fänge & Mattisson, 1981;Fänge & Pulsford, 1983;D'Ippolito et al, 1985;Hine & Wain, 1987a, b, c;Galindez & Aggio, 1996;Zapata et al, 1996;Walsh & Luer, 1998) it may be assumed that the progenitor cells are localized more frequently in the epigonal organ of R. lalandii.…”

Section: Discussionmentioning

confidence: 69%

“…Granulocytopoiesis is one of the principal functional characteristics ascribed to the epigonal and to the Leydig organ in several species of elasmobranchs (D'Ippolito et al, 1985;Hine & Wain 1987a, b, c;Zapata et al, 1996;Walsh & Luer, 1998). This process is not exercised by both organs equally, however, since while one organ is usually voluminous, the other is poorly developed or even absent, suggesting a histophysiological compensational mechanism between them (Fänge, 1977).…”

Section: Discussionmentioning

confidence: 99%

“…Although they lack bone marrow, they have a spleen, a thymus and also two haematopoietic organs: the epigonal organ in association with the gonads and the Leydig organ localized in the submucosa of the oesophagus (Zapata et al, 1996). Granulocyte production occurs in the epigonal and Leydig organs (D'Ippolito et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

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Development of granulocytes in haematopoietic tissues of Rhizoprionodon lalandii

Pacheco¹,

Pacheco²,

Segreto

et al. 2002

Journal of Fish Biology

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Granulocytes of the epigonal and Leydig organs of Rhizoprionodon lalandii were identified and classified into three different cell types, type I and type II eosinophils and neutrophils. The development of these cells in the haematopoietic tissues was dynamic, demonstrated by nuclear immunopositivity for the proliferating cell nuclear antigen (PCNA) proteins and was regulated by various cytokines, including the transforming growth factor -1 (TGF 1 ). The expression pattern of these cells was heterogeneous among individual cells and TGF 1 -immunostaining was found principally in the cytoplasm of immature granulocytes. The presence of TGF 1 in cells about to divide was demonstrated suggesting that modulation of differentiation and proliferation occurs in the haematopoietic tissues of this species of elasmobranch.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

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Development of granulocytes in haematopoietic tissues of Rhizoprionodon lalandii

Pacheco¹,

Pacheco²,

Segreto

et al. 2002

Journal of Fish Biology

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“…The spleen of the nurse shark is separated into distinct RP and WP, although no defining border or MZ exists between the two (Zapata et al 1996). The RP of the nurse shark spleen contains macrophages and erythrocytes, as well as Ig-secreting plasma cells (Castro et al 2013, Rumfelt et al 2002), which are localized predominantly at the periphery of the WP and at the splenic capsule.…”

Section: Elasmobranchsmentioning

confidence: 99%

Emergence and Evolution of Secondary Lymphoid Organs

Neely

Flajnik

2016

Annu. Rev. Cell Dev. Biol.

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For effective adaptive immunity to foreign antigens (Ag), secondary lymphoid organs (SLO) provide the confined environment in which Ag-restricted lymphocytes, with very low precursor frequencies, interact with Ag on Ag-presenting cells (APC). The spleen is the primordial SLO, arising in conjunction with adaptive immunity in early jawed vertebrates. The spleen, especially the spleen’s lymphoid compartment, the white pulp (WP), has undergone numerous modifications over evolutionary time. We describe the progressive advancement of splenic WP complexity, which evolved in parallel with the increasing functionality of adaptive immunity. The Ag-presenting function of follicular dendritic cells (FDC) also likely emerged at the inception of adaptive immunity, and we propose that a single type of hematopoietically derived APC displayed Ag to both T and B cells. A dedicated FDC, derived from a vascular precursor, is a recent evolutionary innovation that likely permitted the robust affinity maturation found in mammals.

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“…Additionally, genes required for lymphopoiesis and Ig gene rearrangement/diversification, such as PU.1 , Ikaros , RAG1 , RAG2 and TdT , as well as primary and secondary lymphoid tissues, are also present within this vertebrate class [3-8]. Cartilaginous fish genomic Ig gene segments are organized in ~10 kb clusters, each containing one variable segment ( V ), two to three diversity segments ( D ) depending on the VH class, a joining segment ( J ), and constant gene exons ( C ); in all expression studies to date these gene segments undergo rearrangement only within a cluster [1,9,10].…”

Section: Introductionmentioning

confidence: 99%

Diversity and repertoire of IgW and IgM VH families in the newborn nurse shark

et al. 2004

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Background: Adult cartilaginous fish express three immunoglobulin (Ig) isotypes, IgM, IgNAR and IgW. Newborn nurse sharks, Ginglymostoma cirratum, produce 19S (multimeric) IgM and monomeric/dimeric IgM 1gj , a germline-joined, IgM-related VH, and very low amounts of 7S (monomeric) IgM and IgNAR proteins. Newborn IgNAR VH mRNAs are diverse in the complementarity-determining region 3 (CDR3) with non-templated nucleotide (N-region) addition, which suggests that, unlike in many other vertebrates, terminal deoxynucleotidyl transferase (TdT) expressed at birth is functional. IgW is present in the lungfish, a bony fish sharing a common ancestor with sharks 460 million years ago, implying that the IgW VH family is as old as the IgM VH family. This nurse shark study examined the IgM and IgW VH repertoire from birth through adult life, and analyzed the phylogenetic relationships of these gene families.

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Structure of the lymphoid organs of elasmobranchs

Cited by 46 publications

References 48 publications

Development of granulocytes in haematopoietic tissues of Rhizoprionodon lalandii

Development of granulocytes in haematopoietic tissues of Rhizoprionodon lalandii

Emergence and Evolution of Secondary Lymphoid Organs

Diversity and repertoire of IgW and IgM VH families in the newborn nurse shark

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