“…The BR and AR are separated in the primary sequence of human FV by ϳ480 amino acids. Interestingly, approximately half of this region has 31 copies of 9-amino acid tandem repeats (9,45,46). However, lower vertebrates such as lizard, chicken, and pufferfish do not have any repeat segments, and the length separating the BR and AR is very short at Ͻ55 residues in these species.…”