Structure of acyl derivatives of the fungicide diazoxolon and related Aryl-hydrazonoisoxazolones

Abstract

Sodium salts of drazoxolon and related 4-arylhydrazono-3- methylisoxazol-5-ones react with acyl chlorides in dry acetone to form 2-acyl-4-arylazo-3-methylisoxazol-5-ones, the structures of which were deduced from their i.r. and u.v. spectra. Several 2-acyl-4- arylazo-3- methylisoxazol-5-ones show considerable fungicidal activity against a number of plant pathogens.

[Bmim]BF4: A Versatile Ionic Liquid for the Synthesis of Diverse Bioactive Heterocycles

“…Isoxazoles and isoxazolines are important classes of heterocycles possessing a wide spectrum of biological activities that include anti‐inflammatory, anti‐fungal, anti‐bacterial, analgesic, hypolipaemic and many more activities. Synthesis of biologically promising 3,5‐disubstitueted isoxazoles ( 67 ) was achieved by Valizadeh et al .…”

Facile Heterocyclic Synthesis and Antibacterial Activity of Substituted Isoxazol‐5(4H)‐ones

“…Isoxazol‐5(4 H )‐ones are important five‐membered heterocycles characterized by a nitrogen–oxygen bond and are useful in the syntheses of various other heterocycles such as 1,3‐oxazin‐6‐ones, pyrroles, imidazoles, tetrahydropyridines, pyridopyrimidines, and 2 H ‐azirines . Additionally, isoxazol‐5(4 H )‐one derivatives have attracted much interest because of their significant pharmaceutical and therapeutic properties such as antibacterial, anticonvulsive, antifungal, and antidiabetic, anti‐androgenic, anticancer, and hypoglycemic . Isoxazol‐5(4 H )‐one derivatives are described as gamma‐aminobutyric acid (GABA)‐A receptors, potent inhibitors of PTP1B .…”

“…[3][4][5][6][7][8] Additionally, isoxazol-5(4H)-one derivatives have attracted much interest because of their significant pharmaceutical and therapeutic properties such as antibacterial, anticonvulsive, antifungal, and antidiabetic, [9][10][11][12][13] anti-androgenic, anticancer, and hypoglycemic. 2,[9][10][11][12]14 Isoxazol-5(4H)one derivatives are described as gamma-aminobutyric acid (GABA)-A receptors, potent inhibitors of PTP1B. 15,16 They act as inhibitors of the tumor necrosis factor-alpha.…”

Reaction of N‐(phenyl and methyl)‐C‐arylnitrones with DMAD in ionic liquid: Efficient synthesis of Δ4‐isoxazolines

“…Nitrogen and oxygen containing heterocyclic compounds are very important organic compounds because of their wide range of pharmacological activity. Isoxazolines represent one of the active classes of compounds possessing a wide spectrum of biological activities such as antidiabetic [1], diuretic [2], analgesic [3], anthelimentic [4], hypolipaemic [5] and antimicrobial activity [6]. One of the most common procedures for the synthesis of these compounds is cycloaddition reaction of 1,3‐dipoles to olefins.…”