Structure of a novel metabolite from deoxynivalenol, a trichothecene mycotoxin, in animals.

Abstract

Deoxynivalenol(DON), 3a,7a,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one, is a toxic metabolite such Fusarium spp. as F.

LC–MS/MS characterization of the urinary excretion profile of the mycotoxin deoxynivalenol in human and rat

“…DOM-1 was first identified in urine from Wistar rats by Yoshizawa et al [24], further studies confirmed the presence of this metabolite in excreta of oral administered PVG rats [7,11]. On the other hand, DOM-1 was not detected in urine from Sprague-Dawley rats, that were found to contain a significant portion of DON glucuronide [9].…”

Biological detoxification of fungal toxins and its use in plant breeding, feed and food production

“…Detoxification of trichothecenes in vitro in bovine ruminal fluid by reductive deepoxidation, leading to 12,13-olefin, was first observed for DON (King et al, 1984). The same metabolite was found in urine and faeces of rats (Yoshizawa et al, 1983;Lake et al, 1987) and dairy cows (Cote et al, 1986) fed with DON. However, these experiments were performed by feeding whole animals with DON and it was not clear whether the transformation resulted from animal metabolism or from activities of microflora in their digestive tract.…”

Nontransmission of deoxynivalenol (vomitoxin) to milk following oral administration to dairy cows

“…<5-10 ppm) represents any type of potential human health problem. However, the possibility of DON metabolite formation (Yoshizawa et al, 1983) should be investigated.…”