Structure–function relationships of immunostimulatory polysaccharides: A review

Ferreira, Sónia S.; Passos, Claúdia P.; Madureira, Pedro; Vilanova, Manuel; Coimbra, Manuel A.

doi:10.1016/j.carbpol.2015.05.079

Cited by 761 publications

(363 citation statements)

References 153 publications

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“…The structure-activity relationships of immunomodulatory polysaccharides have been studied in the past decades, indicating the interaction of immunostimulatory polysaccharides with cell receptors may trigger signaling pathways and thereby result in the induction of gene transcription (Ferreira, Passos, Madureira, Vilanova, & Coimbra, 2015). A Houttuynia cordata pectic polysaccharide (HCP-2) with a linear chain of 1,4-linked ␣-D-galacturonic acid residues could increase the secretions of IL-1␤, TNF-␣, MIP-1␣, MIP-1␤ and RANTES in human peripheral blood mononuclear cells via TLR-4 mediated signaling .…”

Section: Recognition Of Ljp-31 By Innate Immune Receptorsmentioning

confidence: 99%

Immunomodulatory activity on macrophage of a purified polysaccharide extracted from Laminaria japonica

Fang

Wang

Zha

et al. 2015

Carbohydrate Polymers

134

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Section: Recognition Of Ljp-31 By Innate Immune Receptorsmentioning

confidence: 99%

Immunomodulatory activity on macrophage of a purified polysaccharide extracted from Laminaria japonica

Fang

Wang

Zha

et al. 2015

Carbohydrate Polymers

134

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“…Effects of DNP-W6 and its derivatives on the proliferation of lymphocytes in vitro. linkage are some of the structural features recognized to contribute to the polysaccharides immunostimulatory activity [34]. The content of uronic acids has been considered to play important roles in biological activity [35][36][37], and many acid polysaccharides have immunomodulatory activity [36][37][38].…”

Section: Immunological Activity and Structurementioning

confidence: 99%

Structure elucidation of a pectin fromDendrobium nobileLindl. and its immunological activity

Wang

Zhang

Luo

2018

Biotechnology & Biotechnological Equipment

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In this study, an RG-I pectin DNP-W6 was isolated from the stems of Dendrobium nobile Lindl. (Orchidaceae). It contained mannose, glucose, galactose, galacturonic acid and rhamnose in a molar ratio of 0.6: 1.0: 1.5: 1.1: 1.0. Its structural features were revealed by chemical, physical and spectral analysis. The results suggested that DNP-W6 possessed a backbone of a disaccharide of !4)-a-GalAp-(1!2)-a-Rhap-(1!, with approximate 50% substitution at O-4 of the rhamnopyranosyl residues. The side chains were neutral chains including galactosyl, mannosyl and glucosyl chains. The acetyl content was estimated to be 8.9%. The immunological results indicated that DNP-W6 and its derivatives exhibited different immunological activities in vitro, showing that the side chains and acetyl groups had an important effect on the expression of immunological activities.

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“…Et75A-I fraction only presented 2.2% of UA residues (Table 1) and (1 → 4)-Galp residues, which are diagnostic for pectic polysaccharides AG-I side chains, were not detected ( Table 2). As AG-I have been reported to contribute for macrophage NO production (Ferreira et al, 2015;Inngjerdingen et al, 2008), it is possible that P. tridentatum AG-I also contribute to Et75A immunostimulatory activity. Because de-acetylated galactomannans account for approximately 50% of the carbohydrates present in Et75A-I fraction, only when the macrophages were stimulated with 200 g/mL a significant NO production was observed.…”

Section: Tablementioning

confidence: 99%

In vitro macrophage nitric oxide production by Pterospartum tridentatum (L.) Willk. inflorescence polysaccharides

Martins

Simões

Ferreira

et al. 2017

Carbohydrate Polymers

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a b s t r a c tPterospartum tridentatum (L.) Willk. decoctions of dried inflorescences are used in Portugal due to their claimed beneficial properties for various health disorders. To disclose the potential contribution of its polysaccharides to health benefits, in this work, hot water extracts from P. tridentatum inflorescences were prepared and fractionated by ethanol precipitation and anion exchange chromatography. The fraction rich in acetylated galactomannans evidenced an increase in nitric oxide (NO) production by macrophages. This activity decreased 60-75% after saponification, confirming that acetylation is an important structural feature for this biological property. In addition, the treatment of pectic polysaccharides with endopolygalacturonase showed that type-I and type-II arabinogalactans, as well as low molecular weight galacturonans and xyloglucans, may also contribute to macrophage NO production. Thus, the polysaccharides present in P. tridentatum dried inflorescences may contribute to the health beneficial properties frequently attributed to the decoctions of this plant.

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Structure–function relationships of immunostimulatory polysaccharides: A review

Cited by 761 publications

References 153 publications

Immunomodulatory activity on macrophage of a purified polysaccharide extracted from Laminaria japonica

Immunomodulatory activity on macrophage of a purified polysaccharide extracted from Laminaria japonica

Structure elucidation of a pectin fromDendrobium nobileLindl. and its immunological activity

In vitro macrophage nitric oxide production by Pterospartum tridentatum (L.) Willk. inflorescence polysaccharides

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