Structure/Function Analysis of Truncated Amino-Terminal ACE2 Peptide Analogs That Bind to SARS-CoV-2 Spike Glycoprotein

Mackin, Robert T.; Edwards, J. Vincent; Atuk, E. Berk; Beltrami, Noah; Condon, Brian; Jayawickramarajah, Janarthanan; French, Alfred D.

doi:10.3390/molecules27072070

Cited by 3 publications

(2 citation statements)

References 78 publications

(102 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared to unmodified L163, the L163 analogs exhibited enhanced stability against pH, plasma, and trypsin degradation. Furthermore, Mackin et al 76 conducted structural and functional analysis of ACE2 peptide analogs targeting the spike glycoprotein of SARS‐CoV‐2. They found that among the N‐terminal modifications of the peptide, succinimide acylation exhibited stronger binding affinity compared to the native ACE2 peptide.…”

Section: Modification Of Peptides and Pasmentioning

confidence: 99%

Advances in screening, synthesis, modification, and biomedical applications of peptides and peptide aptamers

Liu,

Lu,

Chen

et al. 2023

BioFactors

View full text Add to dashboard Cite

Peptides and peptide aptamers have emerged as promising molecules for a wide range of biomedical applications due to their unique properties and versatile functionalities. The screening strategies for identifying peptides and peptide aptamers with desired properties are discussed, including high‐throughput screening, display screening technology, and in silico design approaches. The synthesis methods for the efficient production of peptides and peptide aptamers, such as solid‐phase peptide synthesis and biosynthesis technology, are described, along with their advantages and limitations. Moreover, various modification techniques are explored to enhance the stability, specificity, and pharmacokinetic properties of peptides and peptide aptamers. This includes chemical modifications, enzymatic modifications, biomodifications, genetic engineering modifications, and physical modifications. Furthermore, the review highlights the diverse biomedical applications of peptides and peptide aptamers, including targeted drug delivery, diagnostics, and therapeutic. This review provides valuable insights into the advancements in screening, synthesis, modification, and biomedical applications of peptides and peptide aptamers. A comprehensive understanding of these aspects will aid researchers in the development of novel peptide‐based therapeutics and diagnostic tools for various biomedical challenges.

show abstract

Section: Modification Of Peptides and Pasmentioning

confidence: 99%

Advances in screening, synthesis, modification, and biomedical applications of peptides and peptide aptamers

Liu,

Lu,

Chen

et al. 2023

BioFactors

View full text Add to dashboard Cite

show abstract

“…Targeting ACE2 was considered the obvious first-choice target for prophylactic and therapeutic interventions aiming to block virus accessibility to respiratory cells early on in infection [97,98]. Several strategies have been evaluated in vitro and in vivo with varied success, including decoy or soluble ACE2 molecules, pseudoligands with a high ACE2 affinity and blocking antibodies [67,99,100].…”

Section: Ace2 and Tmprss2 As Candidate Targets For Antiviral Therapymentioning

confidence: 99%

Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients

Giotis

Cil

Brooke

2022

Viruses

View full text Add to dashboard Cite

COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), is estimated to have caused over 6.5 million deaths worldwide. The emergence of fast-evolving SARS-CoV-2 variants of concern alongside increased transmissibility and/or virulence, as well as immune and vaccine escape capabilities, highlight the urgent need for more effective antivirals to combat the disease in the long run along with regularly updated vaccine boosters. One of the early risk factors identified during the COVID-19 pandemic was that men are more likely to become infected by the virus, more likely to develop severe disease and exhibit a higher likelihood of hospitalisation and mortality rates compared to women. An association exists between SARS-CoV-2 infectiveness and disease severity with sex steroid hormones and, in particular, androgens. Several studies underlined the importance of the androgen-mediated regulation of the host protease TMPRSS2 and the cell entry protein ACE2, as well as the key role of these factors in the entry of the virus into target cells. In this context, modulating androgen signalling is a promising strategy to block viral infection, and antiandrogens could be used as a preventative measure at the pre- or early hospitalisation stage of COVID-19 disease. Different antiandrogens, including commercial drugs used to treat metastatic castration-sensitive prostate cancer and other conditions, have been tested as antivirals with varying success. In this review, we summarise the most recent updates concerning the use of antiandrogens as prophylactic and therapeutic options for COVID-19.

show abstract

Application of the Nicoya OpenSPR to Studies of Biomolecular Binding: A Review of the Literature from 2016 to 2022

Hanson

Whelan

2023

Sensors

View full text Add to dashboard Cite

The Nicoya OpenSPR is a benchtop surface plasmon resonance (SPR) instrument. As with other optical biosensor instruments, it is suitable for the label-free interaction analysis of a diverse set of biomolecules, including proteins, peptides, antibodies, nucleic acids, lipids, viruses, and hormones/cytokines. Supported assays include affinity/kinetics characterization, concentration analysis, yes/no assessment of binding, competition studies, and epitope mapping. OpenSPR exploits localized SPR detection in a benchtop platform and can be connected with an autosampler (XT) to perform automated analysis over an extended time period. In this review article, we provide a comprehensive survey of the 200 peer-reviewed papers published between 2016 and 2022 that use the OpenSPR platform. We highlight the range of biomolecular analytes and interactions that have been investigated using the platform, provide an overview on the most common applications for the instrument, and point out some representative research that highlights the flexibility and utility of the instrument.

show abstract

Structure/Function Analysis of Truncated Amino-Terminal ACE2 Peptide Analogs That Bind to SARS-CoV-2 Spike Glycoprotein

Cited by 3 publications

References 78 publications

Advances in screening, synthesis, modification, and biomedical applications of peptides and peptide aptamers

Advances in screening, synthesis, modification, and biomedical applications of peptides and peptide aptamers

Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients

Application of the Nicoya OpenSPR to Studies of Biomolecular Binding: A Review of the Literature from 2016 to 2022

Contact Info

Product

Resources

About