Structure-function analysis of the radioprotective and antioxidant activity of flavonoids

Кемертелидзе, Э. П.; Tsitsishvili, Vladimer; Alaniya, M. D.; Sagareishvili, T. G.

doi:10.1007/bf02234904

Cited by 12 publications

(7 citation statements)

References 1 publication

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“…25 Regarding structure-activity relationships, an investigation into the recombination kinetics of a series of flavonoids with the DPPH radical led to the statement that flavonols were the most active. 26 The authors also concluded that glycosylation at C-3 reduced the reactivity if the sugar could form two intramolecular hydrogen bonds, and the most promising antioxidants were found to be lespedin, kaempferitrin, kaempferol, kaempferol-7-rhamnoside, kaempferol-3-robinobioside and robinin. In a similar study it was pointed out that the presence of hydroxyl substituents on the flavonoid core enhanced the activity.…”

Section: Discussionmentioning

confidence: 97%

Assessment of antiradical potential of Calluna vulgaris (L.) Hull and its major flavonoid

et al. 2009

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BACKGROUND: Antioxidant capacity of the chloroform, ethyl acetate, n-butanol and water fractions of the aerial parts of Calluna vulgaris (L.) Hull (Ericaceae) has been assessed in this study. Antioxidant capacity of the plant was screened by assays of 2,2-diphenyl-β-picrylhydrazyl, superoxide anion and hydrogen peroxide scavenging, metal-chelating activity and reducing power. Butylated hydroxyanisole was used as reference in all assays; ethylene diamine tetraacetic acid was also used as reference in the assay of metal-chelating activity. Total phenolic contents of the fractions were determined by the Folin-Ciocalteu method.

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Section: Discussionmentioning

confidence: 97%

Assessment of antiradical potential of Calluna vulgaris (L.) Hull and its major flavonoid

et al. 2009

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“…This innate radioprotective ability is in part due to the numerous antioxidant phytochemicals that they possess as part of normal metabolic processes. Polyphenols like flavonoids and their naturally occurring derivatives are structurally adapted in order to be activated by electron donating substituents which inhibit energy transfer mechanisms, ultimately suppressing oxidative stress and stabilising redox processing cells [ 98 , 99 ].…”

Section: Measures To Minimise Radiation Damagementioning

confidence: 99%

Protection against Radiotherapy-Induced Toxicity

et al. 2016

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Radiation therapy is a highly utilized therapy in the treatment of malignancies with up to 60% of cancer patients receiving radiation therapy as a part of their treatment regimen. Radiation therapy does, however, cause a wide range of adverse effects that can be severe and cause permanent damage to the patient. In an attempt to minimize these effects, a small number of compounds have been identified and are in use clinically for the prevention and treatment of radiation associated toxicities. Furthermore, there are a number of emerging therapies being developed for use as agents that protect against radiation-induced toxicities. The aim of this review was to evaluate and summarise the evidence that exists for both the known radioprotectant agents and the agents that show promise as future radioprotectant agents.

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“…Isoflavonoids form a well-separated flavonoid subclass, as these compounds showed a structural variant feature in which the B-aromatic ring is located at C3 carbon ( Figure 3 ) [ 27 ]. Investigations aimed to explore structural features involved in radioprotection highlighted that some flavonoid compounds (mainly those sharing the keto group conjugated to aromatic rings) could be valid agents, because protection is related to their ability to inhibit energy transfer processes and to stabilize redox processes in irradiated cells [ 28 ].…”

Section: Phenols and Polyphenols: Are They A Valuable Radioprotective Strategy?mentioning

confidence: 99%

“…In fact, it was observed that flavonol glucosides decrease in reactivity when the sugar forms two intramolecular H-bonds. Furthermore, based on aglycone substitution, more phenolic functions are present, more the compound is active [ 28 ]. Among flavonol compounds, rutin (3,3′,4′,5,7-pentahydroxyflavone-3-rhamnoglucoside; Figure 4 ), abundant in passion flower, buckwheat, tea, and apple, is broadly investigated for its radioprotective action.…”

Section: Phenols and Polyphenols: Are They A Valuable Radioprotective Strategy?mentioning

confidence: 99%

Could Polyphenols Really Be a Good Radioprotective Strategy?

et al. 2021

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Currently, radiotherapy is one of the most effective strategies to treat cancer. However, deleterious toxicity against normal cells indicate for the need to selectively protect them. Reactive oxygen and nitrogen species reinforce ionizing radiation cytotoxicity, and compounds able to scavenge these species or enhance antioxidant enzymes (e.g., superoxide dismutase, catalase, and glutathione peroxidase) should be properly investigated. Antioxidant plant-derived compounds, such as phenols and polyphenols, could represent a valuable alternative to synthetic compounds to be used as radio-protective agents. In fact, their dose-dependent antioxidant/pro-oxidant efficacy could provide a high degree of protection to normal tissues, with little or no protection to tumor cells. The present review provides an update of the current scientific knowledge of polyphenols in pure forms or in plant extracts with good evidence concerning their possible radiomodulating action. Indeed, with few exceptions, to date, the fragmentary data available mostly derive from in vitro studies, which do not find comfort in preclinical and/or clinical studies. On the contrary, when preclinical studies are reported, especially regarding the bioactivity of a plant extract, its chemical composition is not taken into account, avoiding any standardization and compromising data reproducibility.

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Structure-function analysis of the radioprotective and antioxidant activity of flavonoids

Cited by 12 publications

References 1 publication

Assessment of antiradical potential of Calluna vulgaris (L.) Hull and its major flavonoid

Assessment of antiradical potential of Calluna vulgaris (L.) Hull and its major flavonoid

Protection against Radiotherapy-Induced Toxicity

Could Polyphenols Really Be a Good Radioprotective Strategy?

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