Assessment of antiradical potential of <i>Calluna vulgaris</i> (L.) Hull and its major flavonoid

Deliorman‐Orhan, Didem; Şenol, Sezer; Kartal, Murat; Orhan, İlkay Erdoğan

doi:10.1002/jsfa.3517

Cited by 15 publications

(16 citation statements)

References 27 publications

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“…Pharmacological studies showed anti-inflammatory (Tunon et al 1995), antioxidant (Calliste et al 2001;Deliorman-Orhan et al 2009;Kaehkoenen et al 1999), antiproliferative (Calliste et al 2001) and MAO-A inhibitory effects (Saaby et al 2009). Its seeds showed moderate antibacterial activity (Kumarasamy et al 2002).…”

Section: Introductionmentioning

confidence: 96%

Phytochemistry of heather (Calluna vulgaris (L.) Hull) and its altitudinal alteration

et al. 2009

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Calluna vulgaris (L.) Hull (heather) is the only species within the genus Calluna (Ericaceae). It is a dominant species of heather communities and can be found in most parts of Europe and Northern America from lowland up to alpine regions. Common heather is traditionally used to treat urinary tract disturbances and inflammatory related disorders. This review covers the current knowledge on phytochemical investigations of C. vulgaris which revealed a complex pattern of flavonoid glycosides including acetylated compounds as well as other classes of phenolics (chromones, procyanidins and simple phenols). Recently, an acetophenone (rodiolinozide) was identified. C. vulgaris occurs in habitats comprising several altitudinal zones which makes it an attractive species to study the variation of its metabolic profiles in wild populations growing under different climatic conditions. Within phenolic compounds, flavonols showed significant differences in samples collected at different altitudes with increased levels of quercetin glycosides at higher altitudes whereas no significant correlation could be found for caffeoyl quinic acids and the dihydroflavonol glycoside callunin. Expanding such investigations to different species and different geographical areas should give a more accurate picture of suitable marker compounds within the group of phenolics in order to detect adaptive processes in high altitude plants. Furthermore, investigations on the specific patterns of phenolics at cellular and subcellular level and their variation due to factors like enhanced solar radiation and low temperature should be expanded.

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Section: Introductionmentioning

confidence: 96%

Phytochemistry of heather (Calluna vulgaris (L.) Hull) and its altitudinal alteration

et al. 2009

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“…vulgaris has been used in ethnopharmacology as an antiseptic, antibacterial, cholagogue, diuretic, expectorant, antirheumatic and anti-inflammatory agent [2]. Several studies revealed antioxidant [3][4][5], antitumor and anti-inflammatory effects of C. vulgaris extract [6]. Heather leaves represent a very promising source of triterpenoids [7].…”

Section: Introductionmentioning

confidence: 99%

In vitro activity of heather [Calluna vulgaris (L.) Hull] extracts on selected urinary tract pathogens

et al. 2014

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Calluna vulgaris L. Hull (Ericaceae) has been used for treatment of urinary tract infections in traditional medicine. In this study we analyzed in vitro antibacterial activity of the plant extracts on different strains of Escherichia coli, Enterococcus faecalis and Proteus vulgaris, as well as the concentrations of total phenols and flavonoids in the extracts. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined. The concentrations of total phenols were examined by using Folin-Ciocalteu reagent and ranged between 67.55 to 142.46 mg GAE/g. The concentrations of flavonoids in extracts were determined using spectrophotometric method with aluminum chloride and the values ranged from 42.11 to 63.68 mg RUE/g. The aqueous extract of C. vulgaris showed a significant antibacterial activity. The values of MIC were in the range from 2.5 mg/ml to 20 mg/ml for this extract. Proteus vulgaris strains were found to be the most sensitive. The results obtained suggest that all tested extracts of C. vulgaris inhibit the growth of human pathogens, especially the aqueous extract.

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“…Ethanolic fraction exhibited the lowest content of reductants despite the investigated heather sample. It was reported that the ethyl acetate extract of aerial part of heather collected in northeastern part of Turkey gave the highest reducing properties (evaluated by Folin-Ciocalteau assay) followed by the n-butanol, chloroform and water [8]. Antioxidant capacity of the studied extracts was also assessed on the basis of their scavenging effect on the stable DPPH radical.…”

Section: Resultsmentioning

confidence: 99%

“…The plant material is a part of traditional folk medicine for treating urinary tract disturbances and inflammatory related disorders [5] as well as against the common cold and rheumatoid arthritis [6]. Pharmacological studies showed also antiseptic, antioxidant and monoamine oxidase A (MAO-A) inhibitory effects [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…The review of literature revealed very little data on antioxidant properties of different extracts of C. vulgaris flowers [8]. From various extraction studies, it was observed that the choice of solvent for extraction of flavonoids from plant materials was not coherent, which can be explained by the differences in the studied matrices as well as the complexity of flavonoids properties [9][10][11] …”

Section: Introductionmentioning

confidence: 99%

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Flavonoid Content and Antioxidant Properties in Different Extracts of Calluna vulgaris (L.) Flowers

Dróżdż¹,

Sentkowska²,

Pyrzyńska³

2017

JAST-A

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This study evaluated the effect of four different solvent, i.e., water, ethanol, water-ethanol mixture and ethyl acetate, on the antioxidant activities of wild and cultivated heather (Calluna vulgaris (L.) Hull) plant. The highest values for total flavonoid content were obtained for samples extracted using ethanol-water mixture and ethyl acetate. Cupric reducing antioxidant capacity (CUPRAC) method, scavenging ability on 1,1-diphenyl-2-pirylhydrazyl radicals (DPPH) radicals and chelating activity on Fe 2+ ions have been used for evaluation of antioxidant activity of the extracts. Ethanolic fraction exhibited the lowest reducing capacity, despite a heather sample used. The extracts of cultivated heather exhibited significant scavenging effect on DPPH radicals, and ethanol and ethanol-water fractions were found to be the most effective. The metal-chelating effect of the extracts increased in the order: ethanol < ethyl acetate < ethanol-water < water. The results may be helpful for better utilization of heather flowers extracts as potential pharmaceutical and nutraceutical ingredient.

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Assessment of antiradical potential of Calluna vulgaris (L.) Hull and its major flavonoid

Cited by 15 publications

References 27 publications

Phytochemistry of heather (Calluna vulgaris (L.) Hull) and its altitudinal alteration

Phytochemistry of heather (Calluna vulgaris (L.) Hull) and its altitudinal alteration

In vitro activity of heather [Calluna vulgaris (L.) Hull] extracts on selected urinary tract pathogens

Flavonoid Content and Antioxidant Properties in Different Extracts of Calluna vulgaris (L.) Flowers

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