Structure elucidation of clavilactone D: an inhibitor of protein tyrosine kinases

Merlini, Lucio; Nasini, Gianluca; Scaglioni, Leonardo; Cassinelli, Giuliana; Lanzi, Cinzia

doi:10.1016/s0031-9422(99)00506-3

Cited by 46 publications

(50 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The ecological analysis of stable C and N isotope ratios by Seitzman et al (2011) indicates that a large component of the Hygrophoraceae is likely biotrophic, including Cuphophyllus, and Cuphophyllus sequences that have been recovered from rhizosphere and root samples. On the other hand, while Hygrophoraceae in general have not been sustained in axenic culture (Griffith et al 2002), Ampulloclitocybe clavipes (Merlini et al 2000), and putatively, Cuphophyllus virgineus (Farrell et al 1977), have been cultured on agar media -a trait shared with saprotrophic species of the basal Hygrophoroid clade such as Aphroditeola (Redhead 2013 Seitzman et al (2011) support retaining Cuphophyllus in Hygrophoraceae, the branching order in the phylogenies is too unstable and the support levels for the branching order along the backbone are too low to definitively include or exclude it from the Hygrophoraceae. The instability of the branching order among analyses in this basal region of the phylogenetic tree suggests that new/different genes or approaches will likely be needed to resolve these deep branches.…”

Section: Subgenera Included Lichenomphalia and Protolichenomphaliamentioning

confidence: 99%

Molecular phylogeny, morphology, pigment chemistry and ecology in Hygrophoraceae (Agaricales)

et al. 2013

View full text Add to dashboard Cite

Molecular phylogenies using 1-4 gene regions and information on ecology, morphology and pigment chemistry were used in a partial revision of the agaric family Hygrophoraceae. The phylogenetically supported genera we recognize here in the Hygrophoraceae based on these and previous analyses are: Acantholichen, Ampulloclitocybe, Arrhenia, Cantharellula, Cantharocybe, Chromosera, Chrysomphalina, Cora, Corella, Cuphophyllus, Cyphellostereum, Dictyonema, Eonema, Gliophorus, Haasiella, Humidicutis, Hygroaster, Hygrocybe, Hygrophorus, Lichenomphalia, Neohygrocybe, Porpolomopsis and Pseudoarmillariella. A new genus that is sister to Chromosera is described as Gloioxanthomyces. Revisions were made at the ranks of subfamily, tribe, genus, subgenus, section and subsection. We present three new subfamilies, eight tribes (five new), eight subgenera (one new, one new combination and one stat. nov.), 26 sections (five new and three new combinations and two stat. nov.) and 14 subsections (two new, two stat. nov.). Species of Chromosera, Gliophorus, Humidicutis, and Neohygrocybe are often treated within the genus Hygrocybe; we therefore provide valid names in both classification systems. We used a minimalist approach in transferring genera and creating new names and combinations. Consequently, we retain in the Hygrophoraceae the basal cuphophylloid grade comprising the genera Cuphophyllus, Ampulloclitocybe and Cantharocybe, despite weak phylogenetic support. We include Aeruginospora and Semiomphalina in Hygrophoraceae based on morphology though molecular data are lacking. The lower hygrophoroid clade is basal to Hygrophoraceae s.s., comprising the genera Aphroditeola, Macrotyphula, Phyllotopsis, Pleurocybella, Sarcomyxa, Tricholomopsis and Typhula.

show abstract

Section: Subgenera Included Lichenomphalia and Protolichenomphaliamentioning

confidence: 99%

Molecular phylogeny, morphology, pigment chemistry and ecology in Hygrophoraceae (Agaricales)

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Basidomycetes of genus Clitocybe are known to produce many types of biologically active compounds. Previous studies on some species of this genus revealed that a large number of sesquiterpenes, such as protoilludene, 1) allenes, 2) marasmanes, 3) acetylenes 4) and calvilactones 5) showed pharmacological properties, including antibacterial, antifungal and antitumor activities. Recent research showed that a novel diterpene alkaloid was isolated from the cultures of C. concave.…”

Section: Notesmentioning

confidence: 99%

Sesquiterpenes from Cultures of the Basidiomycete Clitocybe conglobata and Their 11.BETA.-Hydroxysteroid Dehydrogenase Inhibitory Activity

Sheng

Zhou

et al. 2009

Chem. Pharm. Bull.

View full text Add to dashboard Cite

A new drimane sesquiterpenoid, 3-keto-drimenol (1), were isolated from cultures of the basidiomycete Clitocybe conglobata together with 3b b-hydroxy-11-acetyldrimene (2), 3b b-hydroxydrimenol (3), 11,12-dihydroxydrimene (4), 3b b-hydroxy-11,12-O-isopropyldrimene (5), and 3b b,11,12-trihydroxydrimene (6). Their structures were established from MS and NMR experiments. Compounds 1, 3, and 6 showed inhibitory activities against two isozymes of 11b b-hydroxysteroid dehydrogenases with IC 50 1.7-8.0 m mg/ml (human 11b b-HSD1), 10.7-24.1 m mg/ml (mouse 11b b-HSD1); 177.0-220.0 m mg/ml (human 11b b-HSD2), 250.5-500.2 m mg/ml (mouse 11b b-HSD2), respectively, which catalyze the interconversion of active cortisol and inactive cortisone.

show abstract

“…Among hibarimicins, the polyketide 156 was the most potent tyrosine kinase inhibitor, while hibarimicin B (157), also known as angelmicin B (Fig. 5.20), are metabolites of the fungus, Clitocybe clavipes [242,243]. Complex structural feature and biological activities of 156 and 157 have attracted organic chemists to develop synthetic strategies for the total synthesis of these tyrosine kinase inhibitors [236][237][238][239].…”

Section: Inhibitors Of Tyrosine Kinases As Anticancer Agentsmentioning

confidence: 99%

Anticancer Drugs and Potential Anticancer Leads Inspired by Natural Products

Kittakoop

2015

Studies in Natural Products Chemistry

View full text Add to dashboard Cite

Structure elucidation of clavilactone D: an inhibitor of protein tyrosine kinases

Cited by 46 publications

References 4 publications

Molecular phylogeny, morphology, pigment chemistry and ecology in Hygrophoraceae (Agaricales)

Molecular phylogeny, morphology, pigment chemistry and ecology in Hygrophoraceae (Agaricales)

Sesquiterpenes from Cultures of the Basidiomycete Clitocybe conglobata and Their 11.BETA.-Hydroxysteroid Dehydrogenase Inhibitory Activity

Anticancer Drugs and Potential Anticancer Leads Inspired by Natural Products

Contact Info

Product

Resources

About