Anticancer Drugs and Potential Anticancer Leads Inspired by Natural Products

Kittakoop, Prasat

doi:10.1016/b978-0-444-63460-3.00005-5

Cited by 16 publications

(10 citation statements)

References 284 publications

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“…Although these screens have assisted in the bioguided isolation of many active compounds, they are considered non-specific for the discovery of the next generation of drugs. Fortunately, a large number of specific biochemical and genetics-based screens are now available routinely [848][849][850]. The chamigrane ma'iliohydrin (36) displayed cytotoxicity in the NCI 60-cell line human tumor screen at a mean panel GI 50 concentration of 10 À5 M, with the greatest activity observed for the NCI/ADR-RES breast cancer cell line (GI 50 ¼ 10 À8 M) [148].…”

Section: Cytotoxic Activitymentioning

confidence: 99%

The Laurencia Paradox: An Endless Source of Chemodiversity

Harizani

Iοannou

Roussis

2016

Progress in the Chemistry of Organic Natural Products 102

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Nature, the most prolific source of biological and chemical diversity, has provided mankind with treatments for health problems since ancient times and continues to be the most promising reservoir of bioactive chemicals for the development of modern drugs. In addition to the terrestrial organisms that still remain a promising source of new bioactive metabolites, the marine environment, covering approximately 70% of the Earth's surface and containing a largely unexplored biodiversity, offers an enormous resource for the discovery of novel compounds. According to the MarinLit database, more than 27,000 metabolites from marine macro- and microorganisms have been isolated to date providing material and key structures for the development of new products in the pharmaceutical, food, cosmeceutical, chemical, and agrochemical sectors. Algae, which thrive in the euphotic zone, were among the first marine organisms that were investigated as sources of food, nutritional supplements, soil fertilizers, and bioactive metabolites.Red algae of the genus Laurencia are accepted unanimously as one of the richest sources of new secondary metabolites. Their cosmopolitan distribution, along with the chemical variation influenced to a significant degree by environmental and genetic factors, have resulted in an endless parade of metabolites, often featuring multiple halogenation sites.The present contribution, covering the literature until August 2015, offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. Since mollusks feeding on Laurencia are, in many cases, bioaccumulating, and utilize algal metabolites as chemical weaponry against natural enemies, metabolites of postulated dietary origin of sea hares that feed on Laurencia species are also included in the present review. Altogether, 1047 secondary metabolites, often featuring new carbocyclic skeletons, have been included.The chapter addresses: (1) the "Laurencia complex", the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; (2) the secondary metabolites, which are organized according to their chemical structures and are classified into sesquiterpenes, diterpenes, triterpenes, acetogenins, indoles, aromatic compounds, steroids, and miscellaneous compounds, as well as their sources of isolation which are depicted in tabulated form, and (3) the biological activity organized according to the biological target and the ecological functions of Laurencia metabolites.

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Section: Cytotoxic Activitymentioning

confidence: 99%

The Laurencia Paradox: An Endless Source of Chemodiversity

Harizani

Iοannou

Roussis

2016

Progress in the Chemistry of Organic Natural Products 102

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“…[6][7][8][9] More than 60% of the clinically approved anticancer drugs are derivatives of medicinal plant. [10][11][12] Interestingly, herbal medicines are still considered as the primary source of treatment in underdeveloped countries. [13] There is enormous scientific interest in the identification of drug molecules or use herbal formulations against cancer because they are considered to be less toxic to normal cells and more tolerable.…”

Section: Original Articlementioning

confidence: 99%

Untitled

Moglad

2019

AJP

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Objective: The objective of this study was to evaluate the cytotoxic, apoptotic, and cell cycle effect of four fractions obtained from the whole aerial part of Solanum nigrum, against three cancer cell lines (MCF-7, A2780, and HT29) and one normal cell line (MRC-5). Materials and Methods: MTT assay was used to assess the cytotoxicity of the four fractions. Then, the most active fraction (ethyl acetate) was further examined by annexin V propidium iodide (PI)/FITC apoptosis assay, cell cycle analysis in MCF7 cells followed by gas chromatographymass spectrometry (GC-MS) analysis. Results: The highest growth inhibition activity was obtained by the ethyl acetate fraction (IC 50 10-12 µg/ml) against the three cell lines and that fraction spared the normal cell line MRC5 with IC 50 of 31.78 µg/ml. Annexin V PI/FITC revealed a dose-dependent induction of apoptosis in MCF7 cells when treated the ethyl acetate fraction; which also caused a non-dose dependent S phase arrest. The GC-MS analysis of the ethyl acetate fraction showed fatty acids and esters of fatty acids as the significant components. Conclusion: The ethyl acetate fraction from S. nigrum strongly inhibited the growth of breast, ovarian, and colon cancer cell lines, and it was three folds selective against the normal fibroblasts. It also caused the induction of early apoptosis and S phase cell cycle block at 10 µg/mL. Future bioassay-guided fractionation of the ethyl acetate fraction could reveal the active compounds, which can be more investigated in further studies.

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“…UM-UC-3), breast cancer (MCF-7), colon cancer (HCT116), cervical cancer (HeLa), gastric cancer (BGC823), kidney cancer (M-1), leukaemia (Jurkat), lung cancer (SHP-77), melanoma (A375), pancreatic adenocarcinoma (SW-1990), ovarian cancer (A2780) and others. Many studies present the anti-cancer effects of various natural extracts [83].…”

Section: In Vitro Protocols For the Evaluation Of Natural Extractsmentioning

confidence: 99%

Romanian Aromatic and Medicinal Plants: From Tradition to Science

Fierăscu¹,

Fierăscu²,

Orţan³

et al. 2017

Aromatic and Medicinal Plants - Back to Nature

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From ancient times, plants have been used by humans for food, fodder, fibre and medicinal purposes. Several plants were empirically considered as treatments for a large array of illness and medical conditions. Each community had specific natural remedies, based on the geographical area, environmental conditions and other factors. Thus, the use of plants can be considered as part of the intangible cultural heritage of each community. In the geographical area of today's Romania, the ancient inhabitants, Dacians, had very good knowledge regarding the use of plants for medicinal purposes, as presented by several historical sources. The present work describes protocols for the extraction and purification of natural extracts, analytical characterisation, in vitro and in vivo evaluation of their potential applications as well as some practical examples of their application on selected Romanian native medicinal and aromatic plants. The presented results offer scientific support to their traditional use, suggesting in the same time some modern applications, for example in the nanotechnology field.

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Anticancer Drugs and Potential Anticancer Leads Inspired by Natural Products

Cited by 16 publications

References 284 publications

The Laurencia Paradox: An Endless Source of Chemodiversity

The Laurencia Paradox: An Endless Source of Chemodiversity

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Romanian Aromatic and Medicinal Plants: From Tradition to Science

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