Structure design mechanisms and inflammatory disease applications of nanozymes

Abstract

Nanozyme is an artificial enzyme with high catalytic activity, low cost, and good biocompatibility, which has received ever-increasing attention in recent years. Various inorganic and organic nanoparticles have been found...

Anti-inflammatory potential of platinum nanozymes: mechanisms and perspectives

“…Their efficiency depends on different features, including size, shape, and surface chemistry. 19 The latter is extremely important for biomedical purposes and the tissue environment where PtNZs should work. In the case of inflammatory disorders, PtNZ immune compatibility and specific extracellular or intracellular localization are crucial to catalyze ROS reduction and decrease the immune reaction.…”

“Three-in-one” platform based on Fe-CDs nanozyme for dual-mode/dual-target detection and NIR-assisted bacterial killing

“…Nanozymes, recognized as one of the top-10 emerging technologies in chemistry by the International Union of Pure and Applied Chemistry (IUPAC) in 2022, have obtained increasing favor from researchers due to their widespread utilization in biomedicine and analytical chemistry. [1][2][3] Different from natural enzymes, nanozymes are superior thanks to their simple preparation, high stability under harsh conditions, and adjustable catalytic activity, making them the ''new darlings'' of researchers. 4 Since the first reported nanozyme of Fe 3 O 4 nanoparticles (NPs) with peroxidase (POD)-like activity in 2007, 5 various nanozymes that mimic the activities of transferases, hydrolases, lyases, oxidoreductases and isomerase have been reported.…”

Recent Advances in Nanozyme‐Based Materials for Inflammatory Bowel Disease

“…[32][33][34] Furthermore, nanozymes inspired by CAT and SOD exhibit considerable potential to mitigate inflammation and improve mucosal healing. [35,36] In this review, the advancement of nanozymes for the treatment of enteritis will be summarized from the perspectives of the structural design of nanomaterials and therapeutic strategies, with the goal of serving as a reference to produce superior nanozymes for moderating inflammation in the future (Figure 1). The potential and current restrictions for using nanozymes in IBD will also be discussed.…”