Structure, bioactivity and applications of natural hyperbranched polysaccharides

Chen, Lei; Ge, Mengdie; Zhu, Yujie; Song, Yen-Ling; Cheung, Peter C.K.; Zhang, Bobo; Li, Liming

doi:10.1016/j.carbpol.2019.115076

Cited by 77 publications

(42 citation statements)

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was proved that polysaccharides isolated from traditional Chinese medicine could activate or regulate T lymphocytes and macrophages, enhance the activity of interleukin, improve the antibody level, and regulate the immune function of the organism [23]. Polysaccharides were also proved an important modulator since they can enhance immunity through different mechanisms, such as stimulation of macrophages, splenocytes, and thymocytes [24]. The carbohydrate-based vaccine is intensively studied for their potentiality to become vaccine candidates.…”

Section: Application In Vaccinementioning

confidence: 99%

“…Polycations, which are prepared by reductive amination reaction between primary amines and periodate oxidized polysaccharides, are considered a new class of non-viral gene delivery systems, cationic polysaccharides are also used as gene transfection vectors [70]. Hydrogels based on cross-linked polysaccharides are used in key applications, such as drug delivery systems and tissue engineering [71], the hyper-branched polymer is considered an excellent carrier for gene delivery nanoparticles [24].…”

Section: Drugs Vaccine Delivery and Tissues Engineeringmentioning

confidence: 99%

See 1 more Smart Citation

Polysaccharides; Classification, Chemical Properties, and Future Perspective Applications in Fields of Pharmacology and Biological Medicine (A Review of Current Applications and Upcoming Potentialities)

2021

View full text Add to dashboard Cite

Polysaccharides are essential macromolecules which almost exist in all living forms, and have important biological functions, they are getting more attention because they exhibit a wide range of biological and pharmacological activities, such as anti-tumour, immunomodulatory, antimicrobial, antioxidant, anticoagulant, antidiabetic, antiviral, and hypoglycemia activities, making them one of the most promising candidates in biomedical and pharmaceutical fields. Polysaccharides can be obtained from many different sources, such as plants, microorganisms, algae, and animals. Due to their physicochemical properties, they are susceptible to physical and chemical modifications leading to enhanced properties, which is the basic concept for their diverse applications in biomedical and pharmaceutical fields. In this review, we will give insight into the most recent updated applications of polysaccharides and their potentialities as alternatives for traditional and conventional therapies. Challenges and limitations for polysaccharides in pharmaceutical utilities are discussed as well.

show abstract

Section: Application In Vaccinementioning

confidence: 99%

Section: Drugs Vaccine Delivery and Tissues Engineeringmentioning

confidence: 99%

Polysaccharides; Classification, Chemical Properties, and Future Perspective Applications in Fields of Pharmacology and Biological Medicine (A Review of Current Applications and Upcoming Potentialities)

2021

View full text Add to dashboard Cite

show abstract

“…A lot of research has been done on hyperbranched bacterial polysaccharides (HBPSs). For example, highly branched dextran with a backbone of 75% (α-(1→6)-D-Glcp) with 19% of α-(1→3) and a few α-(1→2) branching [61], was separated from Leuconostoc citreum B-2 and studied extensively, and showed a water-holding capacity of up to 450% and an 80% water solubility index, consequently having potential applications in cosmetic, food, and pharmaceutical industries [62,63]. From an industrial point of view, EPSs producing Gram-negative prokaryotes (cyanobacteria) are important because of their ability to produce novel molecules.…”

Section: Sources Of Bioactive Polysaccharidesmentioning

confidence: 99%

“…EPSs derived in the laboratory showed widespread biological activities like being an antioxidant, having cholesterol-lowering and inflammation-regulating properties, as well as anti-tumor, anti-coagulant, and antivirus activities [62,68]. Moreover, bacterial polysaccharides are used in Protein Glycan Coupling Technology (PGCT) to produce glycoconjugate vaccines against Gram-positive and Gram-negative bacteria [69].…”

Section: Sources Of Bioactive Polysaccharidesmentioning

confidence: 99%

Sources, Extraction and Biomedical Properties of Polysaccharides

Ullah

Khalil

Shaukat

et al. 2019

Foods

121

View full text Add to dashboard Cite

In the recent era, bioactive compounds from plants have received great attention because of their vital health-related activities, such as antimicrobial activity, antioxidant activity, anticoagulant activity, anti-diabetic activity, UV protection, antiviral activity, hypoglycemia, etc. Previous studies have already shown that polysaccharides found in plants are not likely to be toxic. Based on these inspirational comments, most research focused on the isolation, identification, and bioactivities of polysaccharides. A large number of biologically active polysaccharides have been isolated with varying structural and biological activities. In this review, a comprehensive summary is provided of the recent developments in the physical and chemical properties as well as biological activities of polysaccharides from a number of important natural sources, such as wheat bran, orange peel, barely, fungi, algae, lichen, etc. This review also focused on biomedical applications of polysaccharides. The contents presented in this review will be useful as a reference for future research as well as for the extraction and application of these bioactive polysaccharides as a therapeutic agent.

show abstract

“…Due to the limited availability of natural-derived carbohydrates, chemical synthesis and modi cation to produce a richer variety of natural carbohydrates and non-natural analogs is not only conducive to the biological research of carbohydrates but also essential to the development of carbohydrate drugs [4]. As the saccharide molecule is a six-or ve-membered ring of hemiacetal structure containing polyhydroxyl groups, the selective modi cation of hydroxyl groups in company with the control of the con guration of glycosylation at 1-position have long been two major research focuses in the eld of glycochemistry [5].…”

Section: Introductionmentioning

confidence: 99%

Water-promoted Synthesis of Stereoselective Oxazoline-fused Saccharides and Construction for 1, 2-cis Glycosylamines of Multi-modifications of Polyhydroxyl groups

Dong¹,

Zhao²,

Shi³

et al. 2020

Preprint

View full text Add to dashboard Cite

The multi-modifications of polyhydroxyl groups and the stereoselective formation of 1,2-cis glycosidic bonds are difficult in glycochemistry. Herein we disclosed a concise synthesis of the oxazoline-fused saccharides (oxazolinoses) from acetyl saccharides and benzonitriles under acidic conditions promoted by the stoichiometric water. The oxazolinoses can be easily converted into 1,2-cis glycosylamines with differentiated modifications at 2,3-positions on the saccharide ring in few steps and the 1-NH2 can further be simply transformed to the 1-OH. Oxazolinoses can also be directly used to synthesize complex chiral molecules such as schisandrins. Saccharides screening have shown that the oxazolinoses could be synthesized from various monosaccharides and oligosaccharides. Accordingly, 1-α- or 1-β-1,2-cis glycosylamines can be obtained from different oxazolinoses which are 1,2-cis stereoselectivity controlled by neighboring group participation. The density functional theory (DFT) calculations have revealed the origin of the stereoselectivity and the key role of water.

show abstract

Structure, bioactivity and applications of natural hyperbranched polysaccharides

Cited by 77 publications

References 120 publications

Polysaccharides; Classification, Chemical Properties, and Future Perspective Applications in Fields of Pharmacology and Biological Medicine (A Review of Current Applications and Upcoming Potentialities)

Polysaccharides; Classification, Chemical Properties, and Future Perspective Applications in Fields of Pharmacology and Biological Medicine (A Review of Current Applications and Upcoming Potentialities)

Sources, Extraction and Biomedical Properties of Polysaccharides

Water-promoted Synthesis of Stereoselective Oxazoline-fused Saccharides and Construction for 1, 2-cis Glycosylamines of Multi-modifications of Polyhydroxyl groups

Contact Info

Product

Resources

About