Structure and Stereochemistry of Nardostachysin, a New Terpenoid Ester Constituent of the Rhizomes of Nardostachys jatamansi

Chatterjee, A.; Basak, Bidyut; Saha, Mahua; Dutta, Utpal; Mukhopadhyay, Chaitali; Banerji, Julie; Konda, Yaeko; Harigaya, Yoshihiro

doi:10.1021/np990503m

Cited by 35 publications

(21 citation statements)

References 3 publications

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“…It has protective effect in parkinsonism, epilepsy, cerebral ischemia, liver damage. Various sesquiterpenes (such as Jatamansic acid and Jatamansone) have been reported to be present in the rhizomes of the plant [202]. …”

Section: Introductionmentioning

confidence: 99%

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach

Aggarwal¹,

Prasad²,

Reuter

et al. 2011

CDT

359

155

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Inflammation, although first characterized by Cornelius Celsus, a physician in first Century Rome, it was Rudolf Virchow, a German physician in nineteenth century who suggested a link between inflammation and cancer, cardiovascular diseases, diabetes, pulmonary diseases, neurological diseases and other chronic diseases. Extensive research within last three decades has confirmed these observations and identified the molecular basis for most chronic diseases and for the associated inflammation. The transcription factor, Nuclear Factor-kappaB (NF-κB) that controls over 500 different gene products, has emerged as major mediator of inflammation. Thus agents that can inhibit NF-κB and diminish chronic inflammation have potential to prevent or delay the onset of the chronic diseases and further even treat them. In an attempt to identify novel anti-inflammatory agents which are safe and effective, in contrast to high throughput screen, we have turned to “reverse pharmacology” or “bed to benchside” approach. We found that Ayurveda, a science of long life, almost 6000 years old, can serve as a “goldmine” for novel anti-inflammatory agents used for centuries to treat chronic diseases. The current review is an attempt to provide description of various Ayurvedic plants currently used for treatment, their active chemical components, and the inflammatory pathways that they inhibit.

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Section: Introductionmentioning

confidence: 99%

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach

Aggarwal¹,

Prasad²,

Reuter

et al. 2011

CDT

359

155

View full text Add to dashboard Cite

show abstract

“…A 50% ethanol extract of Nardostachys jatamansi (whole plant) feeding has been found to increase HDL-cholesterol/total cholesterol ratio and also caused a significant reduction in the ratio of total cholesterol/phospholipids (Dixit et al, 1988). Recent studies showed that extracts of the rhizomes of Nardostachys jatamansi also contain hepatoprotective compounds (Ali et al, 2000) and studies have been conducted to elucidate the chemical structure of the active ingredients of this plant (Chatterjee et al, 2000). The present study was undertaken to examine the potential anticonvulsant activity of Nardostachys jatamansi, and the effect of combined treatment of Nardostachys jatamansi and phenytoin in particular, using the maximal electroshock seizure (MES) model.…”

Section: Introductionmentioning

confidence: 99%

Anticonvulsant and neurotoxicity profile of Nardostachys jatamansi in rats

Rao

Karanth

2005

Journal of Ethnopharmacology

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“…jatamansi has been indicated in ayurvedic text to be a potent cardiotonic agent. A number of active components were also isolated from this plant 54) which includes lignans, sesquiterpenes and terpenoids. It has been reported that these compounds possess the cardioprotective effect through antioxidant defense mechanism.…”

Section: Discussionmentioning

confidence: 99%

Protective Efficacy of Nardostachys jatamansi (Rhizomes) on Mitochondrial Respiration and Lysosomal Hydrolases during Doxorubicin Induced Myocardial Injury in Rats

Subashini

Arunachalam

Senthilkumar

et al. 2007

JOURNAL OF HEALTH SCIENCE

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Doxorubicin is highly effective in treatment for several forms of cancer. However, doxorubicin induces a cumulative and dose dependent cardiomyopathy that has been ascribed to redox-cycling of the molecule on the mitochondrial complex 1 generating in the process of increased oxidative stress. In the search of new potential cardioprotective agents, the present study is directed to explore the effect of ethanolic extract of Nardostachys jatamansi on the mitochondrial and lysosomal damage induced by doxorubicin in rats. Heart mitochondria were isolated from rats treated with doxorubicin (15 mg/kg, ip) a single dose, exhibited depressed rates of state 3 respiration, low respiratory control ratio (RCR), decreased Oxidative Phosphorylation ratio, Adenosine Triphosphate content and cytochromes (c, c 1 , b, aa 3 ). In addition the doxorubicin given rats showed significant changes in the lysosomal enzymes (Cathepsin-D, Acid phosphatase, β-D-glucoronidase, β-D-galactosidase and β-N-acetyl glucosaminidase) and membrane bound phosphatases. Also myocardial damage, as assessed by ultrastructural changes showed loss of myofibrils, mitochondrial swelling, and cytoplasmic vacuolization. Pretreatment with Nardostachys jatamansi (500 mg/kg body weight orally) for seven days ameliorated the observed abnormalities and significantly prevented the mitochondrial respiration, lysosomal integrity, membrane bound phosphatases and ultrastructural studies in doxorubicin induced rats. These findings suggest that the cardioprotective efficacy of Nardostachys jatamansi could be mediated possibly through its antioxidant effect as well as by the attenuation of the oxidative stress.

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Structure and Stereochemistry of Nardostachysin, a New Terpenoid Ester Constituent of the Rhizomes of Nardostachys jatamansi

Cited by 35 publications

References 3 publications

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach

Anticonvulsant and neurotoxicity profile of Nardostachys jatamansi in rats

Protective Efficacy of Nardostachys jatamansi (Rhizomes) on Mitochondrial Respiration and Lysosomal Hydrolases during Doxorubicin Induced Myocardial Injury in Rats

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Structure and Stereochemistry of Nardostachysin, a New Terpenoid Ester Constituent of the Rhizomes of Nardostachys jatamansi

Cited by 35 publications

References 3 publications

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: &#x201C;Reverse Pharmacology&#x201D; and &#x201C;Bedside to Bench&#x201D; Approach

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: &#x201C;Reverse Pharmacology&#x201D; and &#x201C;Bedside to Bench&#x201D; Approach

Anticonvulsant and neurotoxicity profile of Nardostachys jatamansi in rats

Protective Efficacy of Nardostachys jatamansi (Rhizomes) on Mitochondrial Respiration and Lysosomal Hydrolases during Doxorubicin Induced Myocardial Injury in Rats

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Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach