Structure and Properties of the di- ((2S) -2-amino-3- (1H-indol-3-yl)propionate)-dihydro-tetraiodide

Abstract

New organic iodine complex in the amino acid - alkali metal salt - iodine - water systemwas synthesized. The physico-chemical properties of complexdi- ((2S) -2-amino-3- (1H-indol-3-yl) propionate)-dihydro-tetraiodide were studied. Microscopic analysis shows that particles of complex have elongated needle-like linear stick-like shapes with average size 2.50-4.00 µm. The cytotoxicity test on MDCK cell culture, antimicrobial activity on S. aureus ATCC 6538-Р (museum susceptible strain); S. aureus ATCC-BAA-39 (museum multiresistant strain); E. coli ATCC 8739 (museum susceptible strain); E. coli ATCC-BAA-196 (museum multiresistant strain); P. aeruginosa ATCC 9027 (museum susceptible strain); P. aeruginosa TA2were observed. Complex has low cytotoxicity, direct antiviral effect, and antimicrobial activity against antibiotic-resistant strains of microorganisms. Di- ((2S) -2-amino-3- (1H-indol-3-yl) propionate)-dihydro-tetraiodide does not cause any mutagenic effect on mammalian cells of the L5178Y line, both in the presence and in the absence of metabolic activation.