Structure and properties of biocompatible poly(glycerol adipate) elastomers modified with ethylene glycol

Navarro, Lucila; Ceaglio, Natalia; Rintoul, Ignacio

doi:10.1038/pj.2017.30

Cited by 26 publications

(18 citation statements)

References 22 publications

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“…The synthesis of the hyperbranched PGA elastomer was carried out through a catalyst-free polycondensation at 150 °C under atmospheric pressure for 17 h, followed by applying a vacuum of 3 mm Hg for 4 h [ 78 ]. PGA prepolymer was then cross-linked by heating at 120 °C for 100 h to prepare an elastomeric material.…”

Section: Polyol Polyesters From Glycerol and Sugar Alcohols (Alditmentioning

confidence: 99%

Review on the Impact of Polyols on the Properties of Bio-Based Polyesters

et al. 2020

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Bio-based polyol polyesters are biodegradable elastomers having potential utility in soft tissue engineering. This class of polymers can serve a wide range of biomedical applications. Materials based on these polymers are inherently susceptible to degradation during the period of implantation. Factors that influence the physicochemical properties of polyol polyesters might be useful in achieving a balance between durability and biodegradability. The characterization of these polyol polyesters, together with recent comparative studies involving creative synthesis, mechanical testing, and degradation, have revealed many of their molecular-level differences. The impact of the polyol component on the properties of these bio-based polyesters and the optimal reaction conditions for their synthesis are only now beginning to be resolved. This review describes our current understanding of polyol polyester structural properties as well as a discussion of the more commonly used polyol monomers.

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Section: Polyol Polyesters From Glycerol and Sugar Alcohols (Alditmentioning

confidence: 99%

Review on the Impact of Polyols on the Properties of Bio-Based Polyesters

et al. 2020

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“…However, PGAd can also be prepared as a hyperbranched polymer. In a recent study, Navarro et al reported the synthesis of hyperbranched PGAd elastomer, using 1:1 and 0.6:1 Gly/AdA molar ratios, at 150 • C, at atmospheric pressure for 17 h and under high vacuum (3 mm Hg) for four more hours (Table 3) [53]. The M n of the obtained PGAd was higher at 1:1 molar ratio while the degree of branching was higher at 0.6:1 molar ratio.…”

Section: Hyperbranched Pgadmentioning

confidence: 99%

Polyglycerol Hyperbranched Polyesters: Synthesis, Properties and Pharmaceutical and Biomedical Applications

Zamboulis

Nakiou

Christodoulou

et al. 2019

IJMS

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In a century when environmental pollution is a major issue, polymers issued from bio-based monomers have gained important interest, as they are expected to be environment-friendly, and biocompatible, with non-toxic degradation products. In parallel, hyperbranched polymers have emerged as an easily accessible alternative to dendrimers with numerous potential applications. Glycerol (Gly) is a natural, low-cost, trifunctional monomer, with a production expected to grow significantly, and thus an excellent candidate for the synthesis of hyperbranched polyesters for pharmaceutical and biomedical applications. In the present article, we review the synthesis, properties, and applications of glycerol polyesters of aliphatic dicarboxylic acids (from succinic to sebacic acids) as well as the copolymers of glycerol or hyperbranched polyglycerol with poly(lactic acid) and poly(ε-caprolactone). Emphasis was given to summarize the synthetic procedures (monomer molar ratio, used catalysts, temperatures, etc.,) and their effect on the molecular weight, solubility, and thermal and mechanical properties of the prepared hyperbranched polymers. Their applications in pharmaceutical technology as drug carries and in biomedical applications focusing on regenerative medicine are highlighted.

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“…The degradation by-products of PGA are adipic acid and glycerol which are safe compounds as approved by FDA (Zhang et al, 2014) (5) The cytotoxicity of PGA has been determined earlier in our group (Kallinteri et al, 2005), and it showed a very low cell toxicity against Human Leukaemia cell line, HL60 cell and Human liver cell lines, HepG2 cells at the top dose of polymer NP, 100 times more of polymer amount required for a therapeutic nano-delivery system. Also, Navarro and his colleagues (Navarro et al, 2017) have used PGA elastomer and it was demonstrated to be non-cytotoxic to embryonic mouse fibroblasts (NIH/3T3) after seeding cells for 6 hours over PGA discs .…”

Section: Preparation and Characterization Of Nanoparticlesmentioning

confidence: 99%

Enhanced nanoparticle uptake into virus infected cells: Could nanoparticles be useful in antiviral therapy?

Abo‐zeid

Urbanowicz

Thomson

et al. 2018

International Journal of Pharmaceutics

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Virus infections cause diseases of different severity ranged from mild infection e.g. common cold into life threatening diseases e.g. Human Immunodeficiency virus (HIV), Hepatitis B. Virus infections represent 44% of newly emerging infections. Although there are many efficient antiviral agents, they still have drawbacks due to accumulation at off target organs and developing of virus resistance due to virus mutation. Therefore, developing a delivery system that can selectively target drug into affected organs and avoid off target accumulation would be a highly advantageous strategy to improve antiviral therapy. Nanoparticles (NP) can be effectively targeted to the liver, and therefore it could be used for improving therapy of hepatic virus infections including hepatitis B virus and hepatitis C virus (HCV). Many studies were performed to encapsulate antiviral agents into nano-delivery system to improve their pharmacokinetics parameters to have a better therapeutic efficacy with lower side effects. However, the effect of virus infection on the uptake of NP has not yet been studied in detail. The latter is a crucial area as modulation of endocytic uptake of nanoparticles could impact on reduce potential therapeutic usefulness of antiviral agents loaded into nano-delivery system. In this study, a fluorescently-labelled polymeric nanoparticle was prepared and used to track NP uptake into Huh7.5, human hepatoma cells transfected with replicating HCV genomes, compared with non-transfected cells as a model representing hepatocyte uptake. Confocal microscopy and flow cytometry of virus transfected Huh7.5 cells unexpectedly demonstrated two-fold increase in uptake of NP compared to non-transfected cells. Therefore, virus transfection enhanced NP uptake into Huh7.5 cells and NP could be considered as a promising delivery system for targeted treatment of hepatitis viruses.

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Structure and properties of biocompatible poly(glycerol adipate) elastomers modified with ethylene glycol

Cited by 26 publications

References 22 publications

Review on the Impact of Polyols on the Properties of Bio-Based Polyesters

Review on the Impact of Polyols on the Properties of Bio-Based Polyesters

Polyglycerol Hyperbranched Polyesters: Synthesis, Properties and Pharmaceutical and Biomedical Applications

Enhanced nanoparticle uptake into virus infected cells: Could nanoparticles be useful in antiviral therapy?

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