Structure and mechanical properties of supercritical carbon dioxide processed porous resorbable polymer constructs

Baker, Kevin C.; Bellair, Robert; Manitiu, Mihai; Herkowitz, Harry N.; Kannan, Rangaramanujam M.

doi:10.1016/j.jmbbm.2008.11.006

Cited by 12 publications

(9 citation statements)

References 21 publications

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“…Representative micro-CT images of the 2D surface and 3D model (a) PDLLA matrices and (b) NPs-loaded PDLLA matrices. growth, which has also been demonstrated in different studies reported in the literature [53,55].…”

Section: Mechanical Propertiessupporting

confidence: 75%

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Hybrid 3D structure of poly(d,l-lactic acid) loaded with chitosan/chondroitin sulfate nanoparticles to be used as carriers for biomacromolecules in tissue engineering

Santo¹,

Duarte²,

Gomes³

et al. 2010

The Journal of Supercritical Fluids

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In the tissue engineering (TE) field, the concept of producing multifunctional scaffolds, capable not only of acting as templates for cell transplantation but also of delivering bioactive agents in a controlled manner, is an emerging strategy aimed to enhance tissue regeneration. In this work, a complex hybrid release system consisting in a three-dimensional (3D) structure based on poly(d,l-lactic acid) (PDLLA) impregnated with chitosan/chondroitin sulfate nanoparticles (NPs) was developed. The scaffolds were prepared by supercritical fluid foaming at 200 bar and 35 • C, and were then characterized by scanning electron microscopy (SEM) and micro-CT. SEM also allowed to assess the distribution of the NPs within the structure, showing that the particles could be found in different areas of the scaffold, indicating a homogeneous distribution within the 3D structure. Water uptake and weight loss measurements were also carried out and the results obtained demonstrated that weight loss was not significantly enhanced although the entrapment of the NPs in the 3D structure clearly enhances the swelling of the structure. Moreover, the hybrid porous biomaterial displayed adequate mechanical properties for cell adhesion and support. The possibility of using this scaffold as a multifunctional material was further evaluated by the incorporation of a model protein, bovine serum albumin (BSA), either directly into the PDLLA foam or in the NPs that were eventually included in the scaffold. The obtained results show that it is possible to achieve different release kinetics, suggesting that this system is a promising candidate for dual protein delivery system for TE applications.

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Section: Mechanical Propertiessupporting

confidence: 75%

“…Usually, stress-strain curves for an open cellular material, in compression, present a linear elastic regime, a plateau and a densification regime [52][53][54]. Beyond the linear region in the stress/strain plot, a permanent deformation will occur, pores will start to collapse and the structure is irreversibly damaged.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Hybrid 3D structure of poly(d,l-lactic acid) loaded with chitosan/chondroitin sulfate nanoparticles to be used as carriers for biomacromolecules in tissue engineering

Santo¹,

Duarte²,

Gomes³

et al. 2010

The Journal of Supercritical Fluids

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“…In sum, PCL samples and PCL/MCM-41 composites presented compressive modulus lower than those characteristic of trabecular and cortical bone (ca. 0.1-5 GPa and 10-20 GPa, respectively) (Baker et al, 2009;Fu et al, 2011;Georgiou et al, 2007). Nevertheless, mechanical properties values comparable to those of natural bones could be attained if the prepared materials are comminuted and introduced into, for example, fast-setting bone/dental cements.…”

Section: Mechanical Compression Testsmentioning

confidence: 99%

Dexamethasone-loaded poly(ɛ-caprolactone)/silica nanoparticles composites prepared by supercritical CO2 foaming/mixing and deposition

Matos

Piedade

Alvarez‐Lorenzo

et al. 2013

International Journal of Pharmaceutics

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A supercritical carbon dioxide (scCO2)-assisted foaming/mixing method (SFM) was implemented for preparing dexamethasone (DXMT)-loaded poly(ε-caprolactone)/silica nanoparticles (PCL/SNPs) composite materials suitable for bone regeneration. The composites were prepared from PCL and mesoporous SNPs (MCM-41/SBA-15) by means of scCO2-assisted SFM at several operational pressures, processing times and depressurization conditions. DXMT was loaded into SNPs (applying a scCO2 solvent impregnation/deposition method - SSID) and into PCL/SNPs composites (using the SFM method). The effects of the employed operational and compositional variables on the physicochemical and morphological features as well as in the in vitro release profiles of DXMT were analyzed in detail. This work demonstrates that the above-referred scCO2-based methods can be very useful for the preparation of DXMT-loaded PCL/SNPs composites with tunable physicochemical, thermomechanical, morphological and drug release properties and suitable for hard-tissue regeneration applications.

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“…Since the pioneering work of Mooney, different polymers were tested. Particularly interesting for biomedical applications are different derivatives of polyesters such as poly(L-lactic acid) [7,8], poly(DL-lactic acid) [9,10], poly(lactic-co-glycolic acid) with different ratios of lactic and glycolic [9,11] and polycaprolactone (PCL). In this work we selected polycaprolactone, a FDAapproved polymer used for several biomedical applications, which has attracted attention in bone tissue engineering for its biocompatibility, bioabsorbability and mechanical properties A C C E P T E D M A N U S C R I P T [12].…”

Section: Introductionmentioning

confidence: 99%

Subcritical carbon dioxide foaming of polycaprolactone for bone tissue regeneration

Duarte

Correia‐Pinto

Reis

et al. 2018

The Journal of Supercritical Fluids

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Structure and mechanical properties of supercritical carbon dioxide processed porous resorbable polymer constructs

Cited by 12 publications

References 21 publications

Hybrid 3D structure of poly(d,l-lactic acid) loaded with chitosan/chondroitin sulfate nanoparticles to be used as carriers for biomacromolecules in tissue engineering

Hybrid 3D structure of poly(d,l-lactic acid) loaded with chitosan/chondroitin sulfate nanoparticles to be used as carriers for biomacromolecules in tissue engineering

Dexamethasone-loaded poly(ɛ-caprolactone)/silica nanoparticles composites prepared by supercritical CO2 foaming/mixing and deposition

Subcritical carbon dioxide foaming of polycaprolactone for bone tissue regeneration

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