Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications

Berger, Julia; Reist, Marianne; Mayer, Joachim M.; Felt, O.; Peppas, Nicholas A.; Gurny, Robert

doi:10.1016/s0939-6411(03)00161-9

Cited by 1,862 publications

(1,212 citation statements)

References 115 publications

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“…Of the physical forms possible, chitosan hydrogels have probably gained the largest interest and they are being developed for numerous applications [5]. One way of describing the different types of hydrogels is to define them from their structure, are they covalently cross-linked or are they not?…”

Section: Open Accessmentioning

confidence: 99%

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Characterization and Properties of Hydrogels Made from Neutral Soluble Chitosans

et al. 2015

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Abstract:The current paper focuses on the preparation and some characteristics of viscoelastic hydrogels, ViscoGels™, made from chitosans having a random acylation pattern. Three different chitosan batches with a high fraction of acetylation were selected based on their Mw, and the impact of degree of cross-linking on these chitosan samples has been studied with respect to the properties of the final hydrogels. Rheological long term (12 month) stability and gelling kinetics data are presented together with results from swelling studies at different pH. Finally, an example illustrating these gels potential as drug delivery vehicles is presented and discussed.

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Section: Open Accessmentioning

confidence: 99%

“…When hydrogels of chitosan are used it has been found that covalent cross-linking is preferred since gels without cross-links have a tendency to dissolve. Another advantage of using covalent cross-linking is that the release rate from the gel can be altered by using different degrees of cross-linking [5].…”

Section: Open Accessmentioning

confidence: 99%

Characterization and Properties of Hydrogels Made from Neutral Soluble Chitosans

et al. 2015

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“…Moreover, it is metabolized by certain human enzymes, especially lysozyme, and is considered biodegradable 9 . Due to its positive charges at physiological pH, chitosan is bio-adhesive, which increases its retention on the site of application 10 . It can also accelerate wound healing 11 .…”

Section: Introductionmentioning

confidence: 99%

Sorbitol-Plasticized and Neutralized Chitosan Membranes as Skin Substitutes

2015

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Chitosan is soluble in diluted acid solutions and can easily form films by casting. However, residual acid neutralization should be performed for biomedical applications what may compromise physical and mechanical properties of the films. Thus, plasticizers can be added to improve these properties. The aim of this study was to characterize morphological, barrier and mechanical properties, besides evaluate the in vitro cytotoxicity of sorbitol-plasticized and NaOH-Na 2 CO 3 neutralized chitosan membranes for skin substitute application. Scanning electron microscopy, X-ray diffraction, water vapor permeability and mechanical tests were carried out to characterize the obtained membranes. Moreover, Vero cells were used for in vitro cytotoxicity evaluation. In this paper, we report a non-cytotoxic sorbitol-plasticized chitosan membrane with desirable properties for skin substitution, such as flexibility, water vapor permeability and high percentage of elongation.

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“…Therefore, CS nanoparticles (NPs) are of great interest as drug delivery systems, including applications for cancer therapy (Chen et al 2014;Deng et al 2014;Trapani et al 2011). The ionotropic gelation technique is particularly suitable for the incorporation of pharmaceuticals, as it can be achieved in aqueous conditions (Agnihotri et al 2004;Berger et al 2004;Fan et al 2012). Moreover, the formation process is solely based on the electrostatic interaction of oppositely charged compounds and, thus, it is not necessary any chemical modification.…”

Section: Introductionmentioning

confidence: 99%

Inclusion of a pH-responsive amino acid-based amphiphile in methotrexate-loaded chitosan nanoparticles as a delivery strategy in cancer therapy

et al. 2015

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The encapsulation of antitumor drugs in nanosized systems with pH-sensitive behavior is a promissing approach that may enhance the success of chemotherapy in many cancers. The nanocarrier dependence on pH might trigger an efficient delivery of the encapsulated drug both in the acidic extracellular environment of tumors and, especially, in the intracellular compartments through disruption of endosomal membrane. In this context, here we reported the preparation of chitosan-based nanoparticles encapsulating methotrexate as a model drug (MTX-CS-NPs), which comprises the incorporation of an amino acid-based amphiphile with pHresponsive properties (77KS) on the ionotropic complexation process. The presence of 77KS clearly gives a pH-sensitive behavior to NPs, which allowed accelerated release of MTX with decreasing pH as well as pH-dependent membrane-lytic activity. This latter performance demonstrates the potential of these NPs to facilitate cytosolic delivery of endocytosed materials.Outstandingly, the cytotoxicity of MTX-loaded CS-NPs was higher than free drug to MCF-7 tumor cells and, to a lesser extent, to HeLa cells. Based on the overall results, MTX-CS-NPs modified with the pH-senstive surfactant 77KS could be potentially useful as a carrier system for intracellular drug delivery and, thus, a promising targeting anticancer chemotherapeutic agent.

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Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications

Cited by 1,862 publications

References 115 publications

Characterization and Properties of Hydrogels Made from Neutral Soluble Chitosans

Characterization and Properties of Hydrogels Made from Neutral Soluble Chitosans

Sorbitol-Plasticized and Neutralized Chitosan Membranes as Skin Substitutes

Inclusion of a pH-responsive amino acid-based amphiphile in methotrexate-loaded chitosan nanoparticles as a delivery strategy in cancer therapy

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