Structure and functional properties of lipoprotein lipase

Wang, Chi-Sun; Hartsuck, Jean A.; McConathy, Walter J.

doi:10.1016/0005-2760(92)90165-r

Cited by 96 publications

(63 citation statements)

References 107 publications

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“…In addition, TRL also include chylomicron and VLDL remnant particles, partially depleted of triglycerides (TG) and enriched with cholesteryl esters. The transformation of TRL into remnant particles is dependent upon TG hydrolysis by lipoprotein lipase (LPL), which is attached to the surface of the vascular endothelium [4]. The enzyme can differentiate between substrates and exhibits specificity with respect to fatty acid length chain and unsaturation [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…The transformation of TRL into remnant particles is dependent upon TG hydrolysis by lipoprotein lipase (LPL), which is attached to the surface of the vascular endothelium [4]. The enzyme can differentiate between substrates and exhibits specificity with respect to fatty acid length chain and unsaturation [4,5]. Therefore, the composition of TRL-TG is decisive for the activity of LPL and the formation of TRL remnants.…”

Section: Introductionmentioning

confidence: 99%

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Minor components of olive oil facilitate the triglyceride clearance from postprandial lipoproteins in a polarity-dependent manner in healthy men

Cabello-Moruno¹,

Martı́nez-Force²,

Montero³

et al. 2014

Nutrition Research

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were isolated from serum at 2, 4 and 6 hours postprandially and their fatty acid and TG molecular species compositions were analyzed by gas chromatography. The apolipoprotein B concentration was determined by immunoturbidimetry. POMACE and OLIVE, differing mainly in their unsaponifiable fraction, led to similar fatty acid and TG molecular species profiles in postprandial TRL. However, POMACE-TRL presented a higher particle size, estimated as TG to apolipoprotein B ratio, which was also found for the main TG molecular species (trioleoyl-glycerol, palmitoyl-dioleoyl-glycerol, palmitoyl-oeloyl-linoleoyl-glycerol, and dioleoyl-linoleoyl-glycerol). TG from POMACE-TRL also showed higher clearance rates. In this regard, apolar TG (with a higher equivalent carbon number) disappeared more rapidly from TRL particles obtained after the ingestion of either POMACE and OLIVE. In conclusion, minor components of POMACE facilitated TG clearance from TRL by modifying their particle size and the hydrolysis of the most apolar species.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Minor components of olive oil facilitate the triglyceride clearance from postprandial lipoproteins in a polarity-dependent manner in healthy men

Cabello-Moruno¹,

Martı́nez-Force²,

Montero³

et al. 2014

Nutrition Research

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“…[2][3] LPL is one member of the triglyceride (TG) lipase gene family, which includes pancreatic lipase (PL), hepatic lipase (HL) and newly discovered endothelium lipase (EL). 4 It is a rate-limiting enzyme in the hydrolysis of triglyceride-rich particles, 5 such as chylomicron and very-low-density lipid (VLDL), thereby providing non-ester acids and 2-monoacylglycerol for tissue use. 6 Recently, in addition to hydrolysis, LPL has been reported to be involved in lipid intake and clearance.…”

Section: Introductionmentioning

confidence: 99%

The common biological basis for common complex diseases: evidence from lipoprotein lipase gene

et al. 2009

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The lipoprotein lipase (LPL) gene encodes a rate-limiting enzyme protein that has a key role in the hydrolysis of triglycerides. Hypertriglyceridemia, one widely prevalent syndrome of LPL deficiency and dysfunction, may be a risk factor in the development of dyslipidemia, type II diabetes (T2D), essential hypertension (EH), coronary heart disease (CHD) and Alzheimer's disease (AD). Findings from earlier studies indicate that LPL may have a role in the pathology of these diseases and therefore is a common or shared biological basis for these common complex diseases. To examine this hypothesis, we reviewed articles on the molecular structure, expression and function of the LPL gene, and its potential role in the etiology of diseases. Evidence from these studies indicate that LPL dysfunction is involved in dyslipidemia, T2D, EH, CHD and AD; and support the hypothesis that there is a common or shared biological basis for these common complex diseases.

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“…Fatty acids are released from circulating VLDL triacylglycerols by the action of the heparin-binding enzyme, lipoprotein lipase (EC 3.1.1.34) (Wang et al, 1992). The enzyme is tightly regulated by the composition of dietary fats (Montalto & Bensadoun, 1993), can differentiate between substrates (Calder et al, 1994) and exhibits speci®city with respect to the position of fatty acid chains in the glycerol backbone (Wang et al, 1982).…”

Section: Discussionmentioning

confidence: 99%

Incorporation of dietary triacylglycerols from olive oil and high-oleic sunflower oil into VLDL triacylglycerols of hypertensive patients

et al. 1999

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Objectives: To establish whether the ingestion of diets enriched with olive oil or high-oleic sun¯ower oil may produce changes in the composition of VLDL triacylglycerols from hypertensive patients. It could be relevant for the uptake and metabolism of triacylglycerol-derived metabolites by extrahepatic tissues. Design: Patients were assigned to the diets in a random-order sequence. Subjects: The participants were 24 hypertensive patients recruited from a religious community. Interventions: The study was conducted over two four week periods with a four week washout period between both MUFA diets. Results: Dietary olive oil kept in balance the content of saturated fatty acids and decreased the content of arachidonic acid in VLDL triacylglycerols. HOSO diet reduced the content of palmitic acid and increased the content of linoleic acid. There was also a decrease in trioleate-glycerol and an increase in tripalmitate-glycerol of VLDL after the MUFA diets, but these effects were more pronounced in the HOSO group. Intake of olive oil decreased the content of disaturated triacylglycerols and increased the content of dioleate-containing triacylglycerols. A decrease in palmitate-dioleate-glycerol after dietary HOSO was observed. Olive oil (but not HOSO) promoted the presence of long-chain PUFA of n-3 family at the sn-2 position of VLDL triacylglycerols. Conclusions: Our data indicate that olive oil and HOSO, providing a similar concentration of MUFA (oleic acid), differ in the formation of VLDL triacylglycerols in hypertensive patients. Sponsorship: This study was supported by a grant (ALI96-0456 and OLI96-2126) from the CICYT, Spain.

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Structure and functional properties of lipoprotein lipase

Cited by 96 publications

References 107 publications

Minor components of olive oil facilitate the triglyceride clearance from postprandial lipoproteins in a polarity-dependent manner in healthy men

Minor components of olive oil facilitate the triglyceride clearance from postprandial lipoproteins in a polarity-dependent manner in healthy men

The common biological basis for common complex diseases: evidence from lipoprotein lipase gene

Incorporation of dietary triacylglycerols from olive oil and high-oleic sunflower oil into VLDL triacylglycerols of hypertensive patients

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