Structure and Function of the Bone Marrow and Hematopoiesis

Gulati, Gene; Ashton, John K.; Hyun, Bong Hak

doi:10.1016/s0889-8588(18)30580-x

Cited by 39 publications

(27 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The bone marrow normally produces approximately 2.5 billion red blood cells, 1.0 billion granulocytes, and 2.5 billion platelets daily per kilogram of body weight (2). However, the marrow has an enormous reserve capacity of 5-10 times normal in times of hematopoietic stress (2). The major components of the bone marrow, as classified by Brown and Gatter, are listed in Table 1 (3).…”

Section: Normal Bone Marrowmentioning

confidence: 99%

Bone marrow aspirate and biopsy: a pathologist's perspective. II. interpretation of the bone marrow aspirate and biopsy

Riley

Williams

Ross

et al. 2009

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Bone marrow examination has become increasingly important for the diagnosis and treatment of hematologic and other illnesses. Morphologic evaluation of the bone marrow aspirate and biopsy has recently been supplemented by increasingly sophisticated ancillary assays, including immunocytochemistry, cytogenetic analysis, flow cytometry, and molecular assays. With our rapidly expanding knowledge of the clinical and biologic diversity of leukemia and other hematologic neoplasms, and an increasing variety of therapeutic options, the bone marrow examination has became more critical for therapeutic monitoring and planning optimal therapy. Sensitive molecular techniques, in vitro drug sensitivity testing, and a number of other special assays are available to provide valuable data to assist these endeavors. Fortunately, improvements in bone marrow aspirate and needle technology has made the procurement of adequate specimens more reliable and efficient, while the use of conscious sedation has improved patient comfort. The procurement of bone marrow specimens was reviewed in the first part of this series. This paper specifically addresses the diagnostic interpretation of bone marrow specimens and the use of ancillary techniques.

show abstract

Section: Normal Bone Marrowmentioning

confidence: 99%

Bone marrow aspirate and biopsy: a pathologist's perspective. II. interpretation of the bone marrow aspirate and biopsy

Riley

Williams

Ross

et al. 2009

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

“…Immune organs are well innervated [39,40] and immune cells have receptors for neurotransmitters and neurohormones. Furthermore, immune cells regularly produce neurotransmitters and neurohormones [41].…”

Section: Resultsmentioning

confidence: 95%

In vitro effect of hormones on the hormone content of rat peritoneal and thymic cells. Is there an endocrine network inside the immune system?

Csaba

Pállinger

2007

Inflamm. res.

View full text Add to dashboard Cite

The results mean that immune cells can be regulated by the neuroendocrine system and could also be able to play a role in endocrine regulation. In addition, taking into account the localization of these cells in the immune organs, there is the possibility of autocrine and paracrine regulation inside the immune system. Considering that the hormones, contained or sensed by the cells of the immune system are influencing each other, the concept of a hormonal network within the immune system can be proposed.

show abstract

“…In our opinion it is most likely that the large variation in the ratio of marrow constituents and trabecular bone [2] is reflected by the variety of signal intensities observed in the normal population. For ethical reasons we were not able to perform bone density measurements in our healthy volunteers to test this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

The signal intensity of the normal odontoid process (dens) displayed on magnetic resonance images

et al. 1992

View full text Add to dashboard Cite

In order to analyse the normal signal intensity of the medullary space of the odontoid process (dens) relative to age, the craniovertebral junction of 33 asymptomatic volunteers in six age groups was examined by means of magnetic resonance imaging. To avoid partial-volume effects 3-mm slices were used in sagittal and axial planes. The signal intensities relative to cerebral white matter varied from 0.51 to 1.23 in the sagittal plane and 0.56 to 1.51 in the axial plane. The signal intensities relative to muscle varied from 0.76 to 2.40 in the sagittal plane and 0.96 to 2.30 in the axial plane. The signal intensities relative to fat varied from 0.22 to 0.62 in the sagittal plane and 0.23 to 0.68 in the axial plane. No correlation with age of the volunteers was found. The normal medulla of the dens may exhibit a low signal intensity on T1-weighted images irrespective of age.

show abstract

Structure and Function of the Bone Marrow and Hematopoiesis

Cited by 39 publications

References 39 publications

Bone marrow aspirate and biopsy: a pathologist's perspective. II. interpretation of the bone marrow aspirate and biopsy

Bone marrow aspirate and biopsy: a pathologist's perspective. II. interpretation of the bone marrow aspirate and biopsy

In vitro effect of hormones on the hormone content of rat peritoneal and thymic cells. Is there an endocrine network inside the immune system?

The signal intensity of the normal odontoid process (dens) displayed on magnetic resonance images

Contact Info

Product

Resources

About