2016
DOI: 10.1016/j.cell.2016.10.028
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Structure and Function of the Nuclear Pore Complex Cytoplasmic mRNA Export Platform

Abstract: Summary The last steps in mRNA export and remodeling are performed by the Nup82 complex, a large conserved assembly at the cytoplasmic face of the nuclear pore complex (NPC). By integrating diverse structural data, we have determined the molecular architecture of the native Nup82 complex at subnanometer precision. The complex consists of two compositionally identical multiprotein subunits that adopt different configurations. The Nup82 complex fits into the NPC through the outer ring Nup84 complex. Our map show… Show more

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Cited by 150 publications
(238 citation statements)
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References 69 publications
(175 reference statements)
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“…These data were then used to solve the structure using an integrative modeling approach 8,9 (Extended Data Fig. 1; Methods; Supplementary Results and Discussion).…”
Section: Resultsmentioning
confidence: 99%
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“…These data were then used to solve the structure using an integrative modeling approach 8,9 (Extended Data Fig. 1; Methods; Supplementary Results and Discussion).…”
Section: Resultsmentioning
confidence: 99%
“…2–3C). To inform the proximities, orientations, and conformations of the Nups, isolated NPCs were subjected to cross-linking with MS readout 9,10 . This approach identified 3,077 unique cross-linked pairs of residues, providing distance restraints between them, both within and between Nups (Fig.…”
Section: Resultsmentioning
confidence: 99%
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