Structure and Cytopathic Effects of Nelson Bay Virus

Gard, G. P.; Compans, Richard W.

doi:10.1128/jvi.6.1.100-106.1970

Cited by 70 publications

(42 citation statements)

References 18 publications

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“…Two reoviruses have been isolated from bats. They include the Nelson Bay virus and Pulau virus [100,101]. The transmissibility and pathogenicity of these viruses to humans are unknown.…”

Section: Reoviridaementioning

confidence: 99%

Bats as a continuing source of emerging infections in humans

Wong

Lau

Woo

et al. 2006

Reviews in Medical Virology

282

237

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Amongst the 60 viral species reported to be associated with bats, 59 are RNA viruses, which are potentially important in the generation of emerging and re-emerging infections in humans. The prime examples of these are the lyssaviruses and Henipavirus. The transmission of Nipah, Hendra and perhaps SARS coronavirus and Ebola virus to humans may involve intermediate amplification hosts such as pigs, horses, civets and primates, respectively. Understanding of the natural reservoir or introductory host, the amplifying host, the epidemic centre and at-risk human populations are crucial in the control of emerging zoonosis. The association between the bat coronaviruses and certain lyssaviruses with particular bat species implies co-evolution between specific viruses and bat hosts. Cross-infection between the huge number of bat species may generate new viruses which are able to jump the trans-mammalian species barrier more efficiently. The currently known viruses that have been found in bats are reviewed and the risks of transmission to humans are highlighted. Certain families of bats including the Pteropodidae, Molossidae, Phyllostomidae, and Vespertilionidae are most frequently associated with known human pathogens. A systematic survey of bats is warranted to better understand the ecology of these viruses.

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“…Two reoviruses have been isolated from bats. They include the Nelson Bay virus and Pulau virus [100,101]. The transmissibility and pathogenicity of these viruses to humans are unknown.…”

Section: Reoviridaementioning

confidence: 99%

Bats as a continuing source of emerging infections in humans

Wong

Lau

Woo

et al. 2006

Reviews in Medical Virology

282

237

View full text Add to dashboard Cite

show abstract

“…Pteropine orthoreovirus (PRV) is a member of Family Reoviridae, genus orthoreovirus. A prototype strain of PRV was first isolated from flying fox (Pteropus poliocephalus) in Nelson Bay, Australia in 1968 (Gard and Compans, 1970;Gard and Marshall, 1973). PRV had been a sole member comprising the PRV group for a considerable period until a second case of the PRV strain Pulau was reported from bat species in Malaysia in 2006 (Pritchard et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Lethal murine infection model for human respiratory disease-associated Pteropine orthoreovirus

et al. 2018

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Pteropine orthoreovirus (PRV) is an emerging bat-borne human pathogen causing severe respiratory illness. To date, however, the evaluation of PRV virulence has largely depended on the limited numbers of clinical cases owing to the lack of animal models. To develop an in vivo model of PRV infection, an inbred C3H mouse strain was infected intranasally with pathogenic PRV strain Miyazaki-Bali/2007. C3H mice suffered severe lung infection with significant body weight reduction and died within 7 days after intranasal infection. Infectious viruses were isolated mainly from the lungs and trachea. Histopathological examination revealed interstitial pneumonia with monocytes infiltration. Following repeated intranasal infection, mice developed antibodies to particular structural and non-structural proteins of PRV. The results of these immunological assays will help to develop laboratory protocols for sero-epidemiological studies. Our small rodent model of lethal respiratory infection will further allow investigation of the molecular mechanisms underlying the high pathogenicity of PRV.

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“…PulV formed large syncytium in Vero cells and showed serologic reactivity against Nelson Bay virus (NBV), another known bat Orthoreovirus isolated from the Australian flying foxes (Pteropus alecto). 91 To date, PulV has not been associated with any human diseases, and very little is known about the host range, pathogenesis, and epidemiology of this newly recognized virus.…”

Section: Pulau Virus and Melaka Virusmentioning

confidence: 99%

Emerging and re-emerging viruses in Malaysia, 1997–2007

Tee

Takebe

Kamarulzaman

2009

International Journal of Infectious Diseases

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Over the past decade, a number of unique zoonotic and non-zoonotic viruses have emerged in Malaysia. Several of these viruses have resulted in significant morbidity and mortality to those affected and they have imposed a tremendous public health and economic burden on the state. Amongst the most devastating was the outbreak of Nipah virus encephalitis in 1998, which resulted in 109 deaths. The culling of more than a million pigs, identified as the amplifying host, ultimately brought the outbreak under control. A year prior to this, and subsequently again in 2000 and 2003, large outbreaks of hand-foot-and-mouth disease due to enterovirus 71, with rare cases of fatal neurological complications, were reported in young children. Three other new viruses - Tioman virus (1999), Pulau virus (1999), and Melaka virus (2006) - whose origins have all been linked to bats, have been added to the growing list of novel viruses being discovered in Malaysia. The highly pathogenic H5N1 avian influenza has also been detected in Malaysia with outbreaks in poultry in 2004, 2006, and 2007. Fortunately, no human infections were reported. Finally, the HIV/AIDS epidemic has seen the emergence of an HIV-1 recombinant form (CRF33_01B) in HIV-infected individuals from various risk groups, with evidence of ongoing and rapid expansion.

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Structure and Cytopathic Effects of Nelson Bay Virus

Cited by 70 publications

References 18 publications

Bats as a continuing source of emerging infections in humans

Bats as a continuing source of emerging infections in humans

Lethal murine infection model for human respiratory disease-associated Pteropine orthoreovirus

Emerging and re-emerging viruses in Malaysia, 1997–2007

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