Structure and characterization of organotin bimetallic supramolecular coordination polymers based on copper cyanide building blocks and pyrazine or pyrazine‐2‐carboxylic acid as new promising anticancer agents

Abstract

The supramolecular coordination polymers (SCP); ∞3[Cu (CN)2(Me3Sn)(pyz)], pyrazine‐trimethyltin‐bis (cyanide) copperI SCP1, [Cu2(CN)3(Ph3Sn)(pyz)], pyrazine‐triphenyltin‐tris (cyanide) dicopperI SCP3 and [Cu2(CN)4(Ph3Sn)(Pyz2caH)2], bis‐pyrazine‐2‐carboxylic acid‐ triphenyltin‐tetrakis (cyanide) dicopperI SCP4 and the coordination complex (CC), [CuII (Pyz2‐ca)2(H2O)2]; diaquo‐bis‐(pyrazine‐2‐carboxylato) copper(II) complex: CC2, are synthesized by self‐assembly method at ambient conditions. Single crystal X‐ray structures of SCP1 and CC2 indicate the presence of CuI and CuII which adopt tetrahedral and octahedron geometry, respectively. The structures of SCP3 and SCP4 are solved by the density functional theory (DFT) calculations and spectroscopic methods. The Cu centers acquire triagonal plane, linear and tetrahedral geometry, respectively. The CN‐R3Sn‐NC spacer and pyrazine or pyrazine‐2‐carboxylic acid ligands extend the structures to 3D‐network. The tested compounds 1–4 are designed and synthesized to examine their effects on viability and proliferation of five human cancer cell lines. Also, they are tested for antioxidant activity using ABTS assay and rate erythrocyte hemolysis.

Nano-metal–organic frameworks as corrosion inhibitors for strengthening anti-corrosion behavior of carbon steel in a sulfuric acid environment: from synthesis to applications

“…Nanoparticles of NMOF 2 were collected in a yield of about 89%. 39 Anal. calcd for NMOF 2 (%): C, 30.07; H, 3.65; N, 15.59; Cu, 17.68; found (%): C, 30.41; H, 3.91; N, 14.52; Cu, 17.79.…”

Host‐guest nanosized coordination complexes based on Ag‐isonicotinic acid‐H2O and Ni‐4,4′‐bipyridine‐aminobenzic acid‐H2O as potentially active anticancer and antimicrobial agents

“…Experimental methods and equipment followed in this research work are as those used in previous works. [ 40,41 ]…”

Nanoscale supramolecular architectures assembly of copper cyanide, organotin, and 1,10‐phenanthroline coordination polymers: Design and biological applications

“…Experimental methods and equipment followed in this research work are as those used in previous works. [ 7,59 ] K 3 [Cu (CN) 4 ] was synthesized according to the literature procedure. [ 59 ]…”

“…Supramolecular coordination polymers (SCPs) and metal organic frameworks (MOFs) belong to the new wide class of organic–inorganic hybrid materials containing cavities or channels, which afford fascinating topologies and plenty diversities. [ 1–6 ] Bimetallic SCPs containing organotin moiety attract recently great attention due to their tunability, high reactivity, and stability in both synthetic and organometallic chemistry [ 7–10 ] as well as their applications in different fields. [ 11–18 ] SCPs based on [Cu n CN m ] X building blocks have received extensive attention, especially on using heterocyclic ligands resulting a variety of different dimensionality networks.…”