Structure and autonomic innervation of the human vas deferens: A review

Dixon, J. S.; Jen, Phillip Y.P.; Gosling, J. A.

doi:10.1002/(sici)1097-0029(19980915)42:6<423::aid-jemt5>3.0.co;2-n

Cited by 28 publications

(8 citation statements)

References 68 publications

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“…Recent publications reiterate observations from an early report that rat vas deferens has an acid luminal pH [41] and go on to show that mechanisms are present in the rat epididymis to maintain an acidic environment that is thought to be required for sperm maturation and storage [16,[35][36][37][42][43][44][45]. Vas deferens epithelia receive extensive innervation [8][9][10][11][12][13], and we have shown that porcine epithelium is responsive to a variety of neurotransmitters [5] and steroid hormones [6]. Neurotransmitter-induced stimulation of HCO 3 Ϫ secretion would be expected to activate sperm during the period of sexual arousal and thus to deliver fully activated sperm at ejaculation [38].…”

Section: Discussionmentioning

confidence: 98%

“…Chronic exposure to glucocorticoids, but not mineralocorticoids, has been associated with the expression of amiloride-sensitive ion transport [4,6]. Vas deferens epithelia receive extensive innervation [8][9][10][11][12][13]; however, direct effects of neurotransmitters on epithelial electrolyte and fluid transport have not been widely studied. A single report indicates that adenosine, ATP, norepinephrine, vasopressin, and histamine increase anion secretion whereas serotonin and carbamylcholine are without effect [5].…”

Section: Introductionmentioning

confidence: 99%

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Adenosine Stimulates Anion Secretion Across Cultured and Native Adult Human Vas Deferens Epithelia1

Carlin

Lee

Marcus

et al. 2003

Biology of Reproduction

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Experiments were conducted to determine the responsiveness of human vas deferens epithelial cell monolayers to adenosine and related agonists. Human abdominal vas deferens epithelial cells have been isolated from adult tissues and grown to confluence on permeable supports. All cells exhibit intense ZO-1 and cytokeratin immunoreactivity. Cultured cell monolayers exhibit high electrical resistance with a lumen-negative potential difference and short circuit current (I(sc)) indicative of anion secretion and/or cation absorption. A portion of the basal I(sc) is inhibited by amiloride. Amiloride-sensitive I(sc) is enhanced by exposure to glucocorticoids and is Na(+) dependent, indicating the presence of epithelial sodium channel-mediated Na(+) absorption. Epithelial anion secretion and intracellular generation of cAMP are acutely stimulated by adenosine and the adenosine receptor agonist 5'-(N-ethylcarboxamido)adenosine (NECA), with these effects being fully blocked by 8-phenyltheophylline. Adenosine receptors are localized to the apical membrane of the epithelial cells, as basolateral adenosine is without effect. Freshly excised human vas deferens recapitulate observations made on cultured epithelia when evaluated with the self-referencing vibrating probe: amiloride inhibition of basal ion transport, stimulation by adenosine, and inhibition by 8-phenyltheophyline. These results demonstrate that adult human vas deferens epithelium actively transports ions to generate the luminal environment of the deferent duct. Thus, vas deferens epithelium likely plays an active role in male fertility, and interventions that modulate epithelial function might be exploited to treat male-factor infertility or in contraception.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Adenosine Stimulates Anion Secretion Across Cultured and Native Adult Human Vas Deferens Epithelia1

Carlin

Lee

Marcus

et al. 2003

Biology of Reproduction

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“…The strong density of S100-IR in the nerve network both in the subepithelial lamina propria and in the muscularis, in accordance with a previous work (Mirabella et al, 2003), showed the presence of a very dense nerve network in both layers. Additionally, the dense nerve network distributed throughout the periductal (Dixon et al, 1998;Mirabella et al, 2003). Also, the higher density of the subepithelial nerve network in the donkey, and the broader propria (140±10 µm vs. 36±5 µm) might reflect the paramount implication of the autonomic nerves in the regulation of the DD function in the donkey.…”

Section: Discussionmentioning

confidence: 99%

“…Also, the higher density of the subepithelial nerve network in the donkey, and the broader propria (140±10 µm vs. 36±5 µm) might reflect the paramount implication of the autonomic nerves in the regulation of the DD function in the donkey. It is obvious that the subepithelial nerves of the DD are assumed to have a secreto-motor function (Dixon et al, 1998;Jen et al, 1999;Mirabella et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Some Comparative Immunohistochemical Studies on the Ductus Deferens in the Donkey (Equus asinus) and Water Buffalo Bull (Bubalus bubalis).

Alkafafy

Attia

Rashed³

et al. 2010

Journal of Veterinary Anatomy

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The current work aimed to apply immunohistochemistry (IHC) to evaluate the differential distribution pattern of some biologically active proteins in the ductus deferens (DD) in two different animal species common in the Egyptian farms. Immunolocalization of S100, angiotensin converting enzyme (ACE), αsmooth muscle actin (α-SMA), connexin 43 (Cx43) and galactosyltransferase (GalTase) was practiced on paraffinembedded sections of DD from clinically healthy adult five donkeys and five water buffalo bulls. The DD, in both species, was lined by a folded, high cuboidal (in donkey) or tall columnar (in buffalo) pseudostratified epithelium with stereocilia. IHC revealed that all antibodies used, displayed variable reactivities in the two species. Nerves and the periductal smooth muscles expressed a strong immunoreactivity (IR) for S100 and α-SMA respectively; both in the donkey and in the buffalo. Stereocilia of principal cells showed a marked ACEimmunostaining in the donkey but not in the buffalo. Cx43-binding sites were found between the basal portions of the ductal epithelium and the subjacent interstitium; as well as among the periductal smooth muscle cells (SMCs) only in the buffalo bulls. Distinct GalTasebinding sites were found in the ductal epithelium only in the donkey. In conclusion the present findings exhibited a species-specific pattern of distribution for most of proteins under study, suggesting a variable functional significance of the DD in the different animal species.

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“…(DIXON, JEN and that seen in the seminiferous tubules of the Galea spixii testis development (SANTOS, OLIVEIRA, SILVA et al, 2012). GOSLING, 1998). For this, structurally, the vas deferens of G.spixii consists of a muscular layer and mucosa.…”

Section: Discussionmentioning

confidence: 99%

Development of epididymis and vas deferens in Galea spixii: an ultrastructural view

et al. 2016

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The study aimed to characterize the ultrastructure of components of the sperm pathway in Galea spixii (Spix's yellow-toothed cavy) at different stages of sexual development. Segments of the epididymis and vas deferens of 10 Galea spixii were studied using scanning and transmission electron microscopy. Principal and basal cells with similar characteristics were seen in the epididymis and vas deferens. Both cell types are responsible for maturation of sperm as well as the ability to fertilize and reabsorption. The post natal morphological development of the epididymis and vas deferens was similar to testicular development of the species.

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Structure and autonomic innervation of the human vas deferens: A review

Cited by 28 publications

References 68 publications

Adenosine Stimulates Anion Secretion Across Cultured and Native Adult Human Vas Deferens Epithelia1

Adenosine Stimulates Anion Secretion Across Cultured and Native Adult Human Vas Deferens Epithelia1

Some Comparative Immunohistochemical Studies on the Ductus Deferens in the Donkey (Equus asinus) and Water Buffalo Bull (Bubalus bubalis).

Development of epididymis and vas deferens in Galea spixii: an ultrastructural view

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