Structure-activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation

Mora, Ana Mariela; Payá, Miguel; Rı́os, José Luis; Alcaraz, Marı́a José

doi:10.1016/0006-2952(90)90317-e

Cited by 303 publications

(167 citation statements)

References 15 publications

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“…The antidiarrhoeal activity of flavonoids has been ascribed to their ability to inhibit intestinal motility and hydro-electrolytic secretion, which are known to be altered in this intestinal condition (Rao et al, 1997). In addition, flavonoids present antioxidant properties which are presumed to be responsible for the inhibitory effects exerted upon several enzymes including those involved in the arachidonic acid metabolism (Mora et al, 1990;Su et al, 2000).…”

Section: Resultsmentioning

confidence: 99%

Antioxidant, antidiarrhoeal and cytotoxic properties of aerial parts of Trichosanthes dioica Roxb.

Akter¹,

Imam²

2011

AJFN

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The present study was designed to investigate the antioxidant, antidiarrhoeal and cytotoxic properties of the aerial parts of Trichosanthes dioica. The petroleum ether, ethyl acetate, methanol and water extracts were tested for antioxidant activity using nitric oxide scavenging assay, total antioxidant capacity and total flavonoid content determination; castor oil-induced and magnesium sulphate-induced diarrhoea in mice were used to evaluate antidiarrhoeal activity while Brine shrimp lethality bioassay was employed for cytotoxicity test. The extracts exhibited significant radical scavenging capacity against nitric oxide. The order of radical scavenging was ascorbic acid > water extract > ethyl acetate extract > methanol extract > petroleum ether extract. The assay also revealed significant total antioxidant activity and a good amount of flavonoids in the extracts. Results of antidiarrhoeal tests at the doses of 200 and 400 mg/kg body weight significantly (p<0.05, 0.001) reduced the frequency and severity of diarrhoea in both animal models. Methanol extract showed the highest inhibition of defaecation. The extracts also showed moderate cytotoxicity against Brine shrimp. The results suggest that aerial parts of Trichosanthes dioica possess significant antioxidant, antidiarrhoeal and moderate cytotoxic activities.

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Section: Resultsmentioning

confidence: 99%

Antioxidant, antidiarrhoeal and cytotoxic properties of aerial parts of Trichosanthes dioica Roxb.

Akter¹,

Imam²

2011

AJFN

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“…This superoxide anion production can be responsible for the increased levels of glutathione determined in ileum and colon, as a compensatory mechanism to avoid the possible effect of oxygen-derived species on intestinal mucosa. The lower induced peroxidation registered in colon can be attributed to the antiperoxidative effect of quercetin, as this aglycone has been described to possess the ability of penetrate in the membranes (Price and Middleton, 1986) where it can exert its well known antioxidant properties (Mora et al, 1990), being also active when nonenzymatic lipid peroxidation was induced on intestinal membrane fractions (data not shown), in the same range of concentrations tht quercitrin did.…”

Section: Discussionmentioning

confidence: 76%

“…Several pharmacological activities have been demonstrated both in vivo and in vitro for these flavonoids, including antiinflammatory (Mascolo et al, 1988), and antithrombotic (Landolfi et al, 1984;Gryglewski et al, 1987) activities. The mechanisms of such pharmacological activities have been related to inhibitory actions on several enzymes (Landolfi et al, 1984;Gryglewski et al, 1987) or to their actions as free radical scavengers and inhibitors of peroxidation (Mora et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Oral administration of quercitrin modifies intestinal oxidative status in rats

Gálvez

Cruz

Zarzuelo

et al. 1994

General Pharmacology: The Vascular System

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“…In vitro and in-vivo experiments have shown that flavonoids are able to inhibit the intestinal secretory response induced by prostaglandins E2 (PGE2) [28], flavonoids have antioxidant properties [29] which are presumed to be responsible for the inhibitory effects exerted upon several enzymes including those involved in the arachidonic acid metabolism [30]. In this study, presence of quercetin and catechin confirmed by HPTLC which are bioflavonoids, may be responsible for the antidiarrhoeal activity of the methanol bark extract of A. catechu.…”

Section: Discussionmentioning

confidence: 99%

Detection of Bioflavonoids from Methanol Bark Extracts of Acacia and their Role as Antidiarrhoeal Agents

Raj¹,

Rai²,

Singh³

2017

JAPLR

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Drugs and chemicalsLoperamide was provided as gift sample (Torrent pharmaceuticals, Sikkim, India), Atropine sulphate (Loba chemie, Pvt. Ltd., Mumbai), Activated charcoal and carboxymetyl cellulose sodium (SD fine chem, Mumbai) was purchased. AbstractA variety of healing properties have been attributed to the extract of Acacia catechu Willd of family Fabaceae in folk medicine. It has been used for the treatment of dysentery, diarrhoea, colitis, ulcers, piles, boils, skin eruptions, inflammation, psoriasis, leprosy, anaemia and leucoderma. Objective of the study was to evaluate the antidiarrhoeal activity of methanol bark extract of Acacia catechu willd against experimentally induced diarrhoea by castor oil in albino rats. The methanol bark extract of Acacia catechu (200 and 250mg/kg body weight) was administered orally to two groups of rats (six animals per group) in order to evaluate the activity of the extract against castor oil induced diarrhoea in animal model rats. Two other groups received distilled water (3ml/ kg, p.o.) and Loperamide (3mg/kg, p.o.) as suspension (1% CMC) which served as positive control. The effect of the bark extract on castor oil induced diarrhoea and gastrointestinal transit (charcoal meal test) was assessed respectively. In this study, the methanol bark extract was qualitatively assayed for presence of carbohydrates, glycosides, proteins, phytosterols, flavonoids, alkaloids and tannins. However, the different compounds like catechin and quercetin were confirmed by HPTLC. At the oral doses of 200 and 250 mg/kg body weight, the plant bark extract showed significant (p<0.05) antidiarrhoeal activity compared to the positive control groups in dose-dependent manner. The present study shows that methanol extract of Acacia catechu has significant antidiarhoeal activity. Keywords: Detection of Bioflavonoids from Methanol Bark Extracts of Acacia and their Role as Antidiarrhoeal Agents 2/7Copyright: ©2017 Raj et al.Apparatus: CAMAG HPTLC system equipped with Linomat V applicator, TLC scanner 3, Reprostar 3 and WIN CATS-4 software was used. Collection and authentication of plant materialCertified sample of methanolic bark extract of Acacia catechu was purchased from Herbo Nutra, Mohan garden, Uttam Nagar, New Delhi-59. Phytochemical testingThe phytochemical analysis of the crude methanol bark extract was chemically assayed for presence of carbohydrates, glycosides, proteins, phytosterols, flavonoids, alkaloids, steroids and tannins. Main chemical constituent's catechin and quercetin were estimated through HPTLC. High performance thin layer chromatographyPreliminary phytochemical screening of Acacia catechu was done to identify the chemical constituents and HPTLC finger printing performed for standardization of the drug. CAMAG HPTLC system equipped with Linomat V applicator, TLC scanner 3, Reprostar 3 and WIN CATS-4 software was used to analyse the methanolic bark extract of Acacia catechu. Sample preparation40 mg of methanol bark extracts of Acacia catechu dissolved in 1 ml of HPTLC grade meth...

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Structure-activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation

Cited by 303 publications

References 15 publications

Antioxidant, antidiarrhoeal and cytotoxic properties of aerial parts of Trichosanthes dioica Roxb.

Antioxidant, antidiarrhoeal and cytotoxic properties of aerial parts of Trichosanthes dioica Roxb.

Oral administration of quercitrin modifies intestinal oxidative status in rats

Detection of Bioflavonoids from Methanol Bark Extracts of Acacia and their Role as Antidiarrhoeal Agents

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